| Gene Symbol |
KCNK2
|
| Entrez Gene |
3776
|
| Alt Symbol |
K2p2.1, TPKC1, TREK, TREK-1, TREK1, hTREK-1c, hTREK-1e
|
| Species |
Human
|
| Gene Type |
protein-coding
|
| Description |
potassium channel, two pore domain subfamily K, member 2
|
| Other Description |
K2P2.1 potassium channel|TREK-1 K(+) channel subunit|TWIK-related potassium channel 1|outward rectifying potassium channel protein TREK-1|potassium channel subfamily K member 2|potassium channel subfamily k member 2 variant 1|potassium channel subfamily k member 2 variant 2|potassium inwardly-rectifying channel, subfamily K, member 2|tandem-pore-domain potassium channel TREK-1|two pore domain potassium channel TREK-1|two pore potassium channel TPKC1|two-pore potassium channel 1
|
| Swissprots |
Q5DP48 Q9UNE3 D3DTA5 B2RCS4 O95069 A8K618 B7ZL56 Q5DP47 A1Z1V3 Q9NRT2
|
| Accessions |
EAW93347 EAW93348 EAW93349 O95069 AF004711 AAD01203 AF129399 AAD47569 AF171068 AAF89743 AK123409 BAC85609 AK291483 BAF84172 AK294780 BAG57907 AK315249 BAG37671 AU280191 AY552980 AAT49015 AY552981 AAT49016 BC069462 AAH69462 BC101693 AAI01694 BC101695 AAI01696 BC143586 AAI43587 CD625291 CD625297 CD625301 DA475072 DR001358 EF165334 ABM47413 EF165335 ABM47414 KF182338 AGW27105 KF182339 AGW27106 XM_011509521 XP_011507823 XM_011509522 XP_011507824 XM_011509523 XP_011507825 XM_011509524 XP_011507826 NM_001017424 NP_001017424 NM_001017425 NP_001017425 NM_014217 NP_055032
|
| Function |
Reversibly converts between a voltage-insensitive potassium leak channel and a voltage-dependent outward rectifying potassium channel in a phosphorylation-dependent manner. {ECO:0000269|PubMed:10784345, ECO:0000269|PubMed:11319556, ECO:0000269|PubMed:24196565}.
|
| Subcellular Location |
Isoform 4: Endoplasmic reticulum membrane {ECO:0000250}; Multi-pass membrane protein {ECO:0000250}.
|
| Tissue Specificity |
Isoform 4 is detected in kidney, adrenal gland and brain where it is preferentially expressed in the amygdala but not found in thalamus, hypothalamus, hippocampus or substantia nigra. {ECO:0000269|PubMed:24196565}.
|
| Top Pathways |
Gastric acid secretion
|