Gene Symbol | Tfb1m |
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Entrez Gene | 224481 |
Alt Symbol | AI429207 |
Species | Mouse |
Gene Type | protein-coding |
Description | transcription factor B1, mitochondrial |
Other Description | S-adenosylmethionine-6-N', N'-adenosyl(rRNA) dimethyltransferase 1|dimethyladenosine transferase 1, mitochondrial|mitochondrial 12S rRNA dimethylase 1|mitochondrial transcription factor B1|mtTFB1 |
Swissprots | Q8JZM0 |
Accessions | EDL01644 Q8JZM0 AF508971 AAM33651 AK028212 AK217882 BC032930 AAH32930 XM_006523220 XP_006523283 XR_385130 NM_146074 NP_666186 |
Function | S-adenosyl-L-methionine-dependent methyltransferase which specifically dimethylates mitochondrial 12S rRNA at the conserved stem loop. Also required for basal transcription of mitochondrial DNA, probably via its interaction with POLRMT and TFAM. Stimulates transcription independently of the methyltransferase activity (By similarity). {ECO:0000250}. |
Subcellular Location | Mitochondrion {ECO:0000250}. |
Tissue Specificity | Ubiquitously expressed. {ECO:0000269|PubMed:12532263}. |
TFB1M CRISPR/Cas9 KO Plasmid (m) - sc-432453 from Santa Cruz Biotechnology
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TFB1M HDR Plasmid (m) - sc-432453-HDR from Santa Cruz Biotechnology
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TFB1M Double Nickase Plasmid (m) - sc-432453-NIC from Santa Cruz Biotechnology
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TFB1M Double Nickase Plasmid (m2) - sc-432453-NIC-2 from Santa Cruz Biotechnology
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TFB1M CRISPR Activation Plasmid (m) - sc-432453-ACT from Santa Cruz Biotechnology
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TFB1M CRISPR Activation Plasmid (m2) - sc-432453-ACT-2 from Santa Cruz Biotechnology
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TFB1M Lentiviral Activation Particles (m) - sc-432453-LAC from Santa Cruz Biotechnology
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TFB1M Lentiviral Activation Particles (m2) - sc-432453-LAC-2 from Santa Cruz Biotechnology
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TFB1M siRNA (m) - sc-154228 from Santa Cruz Biotechnology
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TFB1M shRNA Plasmid (m) - sc-154228-SH from Santa Cruz Biotechnology
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TFB1M shRNA (m) Lentiviral Particles - sc-154228-V from Santa Cruz Biotechnology
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MISSION® esiRNA - EMU038131 from Sigma-Aldrich
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CompoZr® Knockout ZFN Kit - CKOZFN42743 from Sigma-Aldrich
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CompoZr® Knockout ZFN Kit, ZFN plasmid only - CKOZFND42743 from Sigma-Aldrich
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TFB1M siRNA (Mouse) - CRN2367 from Cohesion Biosciences
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TFB1M - MBS8230358 from MyBioSource
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shRNA set against Mouse TFB1M (NM_146074.1) - SHH426132 from Creative biogene
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shRNA set against Mouse Tfb1m(NM_146074.1) - SHL066726 from Creative biogene
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TFB1M shRNA Plasmid (Mouse) - CHN2367 from Cohesion Biosciences
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TFB1M miRNA 3'UTR clone - MiUTR1M-11695 from Creative biogene
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