Gene Symbol | NPY2R |
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Entrez Gene | 4887 |
Alt Symbol | NPY2-R |
Species | Human |
Gene Type | protein-coding |
Description | neuropeptide Y receptor Y2 |
Other Description | NPY-Y2 receptor|neuropeptide Y receptor type 2 |
Swissprots | P49146 Q6AZZ6 Q9UE67 Q4W5G7 Q13457 Q13281 |
Accessions | AAC51115 AAD00248 AAO92062 AAY40940 EAX04901 P49146 BC075052 AAH75052 BC075053 AAH75053 U32500 AAA93170 U36269 AAC50281 U42389 AAB07760 U42766 AAB04120 XM_005263033 XP_005263090 XM_005263034 XP_005263091 NM_000910 NP_000901 |
Function | Receptor for neuropeptide Y and peptide YY. The rank order of affinity of this receptor for pancreatic polypeptides is PYY > NPY > PYY (3-36) > NPY (2-36) > [Ile-31, Gln-34] PP > [Leu- 31, Pro-34] NPY > PP, [Pro-34] PYY and NPY free acid. |
Subcellular Location | Cell membrane; Multi-pass membrane protein. |
Tissue Specificity | High levels in amygdala, corpus callosum, hippocampus and subthalamic nucleus. Also detectable in caudate nucleus, hypothalamus and substantia nigra. |
Top Pathways | Neuroactive ligand-receptor interaction |
NPY2-R CRISPR/Cas9 KO Plasmid (h) - sc-417895 from Santa Cruz Biotechnology
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NPY2-R HDR Plasmid (h) - sc-417895-HDR from Santa Cruz Biotechnology
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NPY2-R Double Nickase Plasmid (h) - sc-417895-NIC from Santa Cruz Biotechnology
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NPY2-R Double Nickase Plasmid (h2) - sc-417895-NIC-2 from Santa Cruz Biotechnology
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NPY2-R CRISPR Activation Plasmid (h) - sc-417895-ACT from Santa Cruz Biotechnology
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NPY2-R CRISPR Activation Plasmid (h2) - sc-417895-ACT-2 from Santa Cruz Biotechnology
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NPY2-R Lentiviral Activation Particles (h) - sc-417895-LAC from Santa Cruz Biotechnology
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NPY2-R Lentiviral Activation Particles (h2) - sc-417895-LAC-2 from Santa Cruz Biotechnology
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NPY2-R siRNA (h) - sc-42101 from Santa Cruz Biotechnology
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NPY2-R shRNA Plasmid (h) - sc-42101-SH from Santa Cruz Biotechnology
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NPY2-R shRNA (h) Lentiviral Particles - sc-42101-V from Santa Cruz Biotechnology
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NPY2R RNAi - H00004887-R01 from Novus Biologicals
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MISSION® esiRNA - EHU050681 from Sigma-Aldrich
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CompoZr® Knockout ZFN Kit - CKOZFN15480 from Sigma-Aldrich
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CompoZr® Knockout ZFN Kit, ZFN plasmid only - CKOZFND15480 from Sigma-Aldrich
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MISSION® 3′UTR Lenti GoClone™ - HUTR10891 from Sigma-Aldrich
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NPY2R siRNA (Human) - CRH3248 from Cohesion Biosciences
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shRNA set against Human NPY2R (NM_000910.2) - SHH354560 from Creative biogene
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shRNA set against Human NPY2R(NM_000910.2) - SHR019514 from Creative biogene
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Human NPY2R siRNA - orb263750 from Biorbyt
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NPY2R shRNA Plasmid (Human) - CHH3248 from Cohesion Biosciences
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NPY2R miRNA 3'UTR clone - MiUTR1H-06886 from Creative biogene
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