Gene Symbol | UGT2B17 |
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Entrez Gene | 7367 |
Alt Symbol | BMND12, UDPGT2B17 |
Species | Human |
Gene Type | protein-coding |
Description | UDP glucuronosyltransferase 2 family, polypeptide B17 |
Other Description | C19-steroid-specific UDP-glucuronosyltransferase|C19-steroid-specific UDPGT|UDP glycosyltransferase 2 family, member B17|UDP-glucuronosyltransferase 2B17|UDP-glucuronyltransferase, family 2, beta-17 |
Swissprots | O75795 |
Accessions | EAW55622 O75795 BC141517 AAI41518 U59209 AAC25491 NM_001077 NP_001068 |
Function | UDPGT is of major importance in the conjugation and subsequent elimination of potentially toxic xenobiotics and endogenous compounds. The major substrates of this isozyme are eugenol > 4-methylumbelliferone > dihydrotestosterone (DHT) > androstane-3-alpha,17-beta-diol (3-alpha-diol) > testosterone > androsterone (ADT). |
Subcellular Location | Microsome membrane {ECO:0000305}; Single- pass membrane protein {ECO:0000305}. Endoplasmic reticulum membrane {ECO:0000305}; Single-pass membrane protein {ECO:0000305}. |
Tissue Specificity | Expressed in various tissues including the liver, kidney, testis, uterus, placenta, mammary gland, adrenal gland, skin and prostate. |
Top Pathways | Chemical carcinogenesis, Steroid hormone biosynthesis, Drug metabolism - other enzymes, Drug metabolism - cytochrome P450, Metabolism of xenobiotics by cytochrome P450 |
UGT2B17 CRISPR/Cas9 KO Plasmid (h) - sc-405611 from Santa Cruz Biotechnology
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UGT2B17 HDR Plasmid (h) - sc-405611-HDR from Santa Cruz Biotechnology
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UGT2B17 Double Nickase Plasmid (h) - sc-405611-NIC from Santa Cruz Biotechnology
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UGT2B17 Double Nickase Plasmid (h2) - sc-405611-NIC-2 from Santa Cruz Biotechnology
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UGT2B17 CRISPR Activation Plasmid (h) - sc-405611-ACT from Santa Cruz Biotechnology
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UGT2B17 CRISPR Activation Plasmid (h2) - sc-405611-ACT-2 from Santa Cruz Biotechnology
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UGT2B17 Lentiviral Activation Particles (h) - sc-405611-LAC from Santa Cruz Biotechnology
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UGT2B17 Lentiviral Activation Particles (h2) - sc-405611-LAC-2 from Santa Cruz Biotechnology
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UGT2B17 siRNA (h) - sc-89184 from Santa Cruz Biotechnology
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UGT2B17 shRNA Plasmid (h) - sc-89184-SH from Santa Cruz Biotechnology
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UGT2B17 shRNA (h) Lentiviral Particles - sc-89184-V from Santa Cruz Biotechnology
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MISSION® esiRNA - EHU146721 from Sigma-Aldrich
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MISSION® esiRNA - EHU106301 from Sigma-Aldrich
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CompoZr® Knockout ZFN Kit - CKOZFN22470 from Sigma-Aldrich
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CompoZr® Knockout ZFN Kit, ZFN plasmid only - CKOZFND22470 from Sigma-Aldrich
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UGT2B17 siRNA (Human) - CRH5038 from Cohesion Biosciences
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UGT2B17 - MBS8226039 from MyBioSource
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Human UGT2B17 siRNA - orb265540 from Biorbyt
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UGT2B17 shRNA Plasmid (Human) - CHH5038 from Cohesion Biosciences
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UGT2B17 miRNA 3'UTR clone - MiUTR3H-04489 from Creative biogene
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