DIO1

Gene Symbol	DIO1
Entrez Gene	1733
Alt Symbol	5DI, TXDI1
Species	Human
Gene Type	protein-coding
Description	deiodinase, iodothyronine, type I
Other Description	DIOI|iodothyronine deiodinase type 1|thyroxine deiodinase type I (selenoprotein)|type 1 DI|type I iodothyronine deiodinase|type-I 5'-deiodinase
Swissprots	Q6Q4C6 Q6Q4C3 Q6Q4C9 Q3KNP8 Q8WWC6 P49895 Q1RN02 Q6Q4C7 Q6Q4C2 Q6Q4C4 Q6Q4C5 Q6Q4C1
Accessions	AAB35380 EAX06720 EAX06721 EAX06722 EAX06723 EAX06724 EAX06725 EAX06726 P49895 AK290780 BAF83469 AW294928 AY560374 AAT02480 AY560375 AAT02481 AY560376 AAT02482 AY560377 AAT02483 AY560378 AAT02484 AY560379 AAT02485 AY560380 AAT02486 AY560381 AAT02487 AY560382 AAT02488 AY560383 AAT02489 BC017955 AAH17955 BC107170 AAI07171 BC107171 AAI07172 CD014030 FJ002243 ACM41656 FJ002244 ACM41657 FJ002245 ACM41658 FJ002247 ACM41660 FJ002248 ACM41661 FJ002249 ACM41662 NM_000792 NP_000783 NM_001039715 NP_001034804 NM_001039716 NP_001034805 NM_213593 NP_998758
Function	Responsible for the deiodination of T4 (3,5,3',5'- tetraiodothyronine) into T3 (3,5,3'-triiodothyronine) and of T3 into T2 (3,3'-diiodothyronine). Plays a role in providing a source of plasma T3 by deiodination of T4 in peripheral tissues such as liver and kidney.
Subcellular Location	Endoplasmic reticulum membrane {ECO:0000250}; Single-pass membrane protein {ECO:0000250}.

• Antibodies
• Assays/Kits
• Proteins/Peptides
• siRNAs/Functional Genomics
• cDNA Clones
• Cell/Tissue/Blood Products

DIO1 CRISPR/Cas9 KO Plasmid (h) - sc-405162 from Santa Cruz Biotechnology Category CRISPR Prices $345.00 Sizes 20 µg Species Reactivities Human

DIO1 HDR Plasmid (h) - sc-405162-HDR from Santa Cruz Biotechnology Prices $345.00 Sizes 20 µg Species Reactivities Human

DIO1 Double Nickase Plasmid (h) - sc-405162-NIC from Santa Cruz Biotechnology Prices $345.00 Sizes 20 µg Species Reactivities Human

DIO1 Double Nickase Plasmid (h2) - sc-405162-NIC-2 from Santa Cruz Biotechnology Prices $345.00 Sizes 20 µg Species Reactivities Human

DIO1 CRISPR Activation Plasmid (h) - sc-405162-ACT from Santa Cruz Biotechnology Category CRISPR Prices $345.00 Sizes 20 µg Species Reactivities Human

DIO1 CRISPR Activation Plasmid (h2) - sc-405162-ACT-2 from Santa Cruz Biotechnology Category CRISPR Prices $345.00 Sizes 20 µg Species Reactivities Human

DIO1 Lentiviral Activation Particles (h) - sc-405162-LAC from Santa Cruz Biotechnology Prices $345.00 Sizes 20 µg Species Reactivities Human

DIO1 Lentiviral Activation Particles (h2) - sc-405162-LAC-2 from Santa Cruz Biotechnology Prices $345.00 Sizes 20 µg Species Reactivities Human

DIO1 siRNA (h) - sc-77146 from Santa Cruz Biotechnology Category siRNA Prices $258.00 Sizes 10 µm Species Reactivities Human

DIO1 shRNA Plasmid (h) - sc-77146-SH from Santa Cruz Biotechnology Category siRNA Prices $258.00 Sizes 10 µm Species Reactivities Human

DIO1 shRNA (h) Lentiviral Particles - sc-77146-V from Santa Cruz Biotechnology Category siRNA Prices $258.00 Sizes 10 µm Species Reactivities Human

MISSION® esiRNA - EHU219171 from Sigma-Aldrich Category siRNA Prices $140.00, $140.00 Sizes 20 µg, 50 µg

CompoZr® Knockout ZFN Kit - CKOZFN7236 from Sigma-Aldrich Category ZFN Kit Prices $4,999.00 Sizes 1 kt

CompoZr® Knockout ZFN Kit, ZFN plasmid only - CKOZFND7236 from Sigma-Aldrich Category ZFN Kit Prices $3,999.00 Sizes 1 kt

MISSION® 3′UTR Lenti GoClone™ - HUTR08000 from Sigma-Aldrich Category miRNA Prices $350.00 Sizes hutr08000

DIO1 siRNA (Human) - CRH1201 from Cohesion Biosciences Category siRNA Prices $340.00, $510.00 Sizes 15 nmol, 30 nmol Species Reactivities Human

DIO1 - MBS8234068 from MyBioSource Prices $365.00, $515.00 Sizes 15 nmol, 30 nmol Species Reactivities Human

shRNA set against Human DIO1 (NM_000792.5) - SHH278109 from Creative biogene Category siRNA Species Reactivities Human

shRNA set against Human DIO1(NM_213593.3) - SHH005447 from Creative biogene Category siRNA Species Reactivities Human

shRNA set against Human DIO1(NM_000792.5) - SHH005473 from Creative biogene Category siRNA Species Reactivities Human

shRNA set against Human DIO1(NM_001039715.1) - SHH005491 from Creative biogene Category siRNA Species Reactivities Human

shRNA set against Human DIO1(NM_001039716.1) - SHH005509 from Creative biogene Category siRNA Species Reactivities Human

shRNA set against Human DIO1(NM_213593.3) - SHH005527 from Creative biogene Category siRNA Species Reactivities Human

Human DIO1 siRNA - orb261703 from Biorbyt Category siRNA Prices $485.00, $629.00 Sizes 15 nmol, 30 nmol Species Reactivities Human

DIO1 shRNA Plasmid (Human) - CHH1201 from Cohesion Biosciences Category siRNA Prices $500.00, $750.00 Sizes 150 µg, 300 µg Species Reactivities Human

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