Gene Symbol | DIO1 |
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Entrez Gene | 1733 |
Alt Symbol | 5DI, TXDI1 |
Species | Human |
Gene Type | protein-coding |
Description | deiodinase, iodothyronine, type I |
Other Description | DIOI|iodothyronine deiodinase type 1|thyroxine deiodinase type I (selenoprotein)|type 1 DI|type I iodothyronine deiodinase|type-I 5'-deiodinase |
Swissprots | Q6Q4C6 Q6Q4C3 Q6Q4C9 Q3KNP8 Q8WWC6 P49895 Q1RN02 Q6Q4C7 Q6Q4C2 Q6Q4C4 Q6Q4C5 Q6Q4C1 |
Accessions | AAB35380 EAX06720 EAX06721 EAX06722 EAX06723 EAX06724 EAX06725 EAX06726 P49895 AK290780 BAF83469 AW294928 AY560374 AAT02480 AY560375 AAT02481 AY560376 AAT02482 AY560377 AAT02483 AY560378 AAT02484 AY560379 AAT02485 AY560380 AAT02486 AY560381 AAT02487 AY560382 AAT02488 AY560383 AAT02489 BC017955 AAH17955 BC107170 AAI07171 BC107171 AAI07172 CD014030 FJ002243 ACM41656 FJ002244 ACM41657 FJ002245 ACM41658 FJ002247 ACM41660 FJ002248 ACM41661 FJ002249 ACM41662 NM_000792 NP_000783 NM_001039715 NP_001034804 NM_001039716 NP_001034805 NM_213593 NP_998758 |
Function | Responsible for the deiodination of T4 (3,5,3',5'- tetraiodothyronine) into T3 (3,5,3'-triiodothyronine) and of T3 into T2 (3,3'-diiodothyronine). Plays a role in providing a source of plasma T3 by deiodination of T4 in peripheral tissues such as liver and kidney. |
Subcellular Location | Endoplasmic reticulum membrane {ECO:0000250}; Single-pass membrane protein {ECO:0000250}. |
DIO1 (H-76) - sc-98392 from Santa Cruz Biotechnology
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DIO1 (C-17) - sc-69381 from Santa Cruz Biotechnology
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DIO1 (L-19) - sc-69385 from Santa Cruz Biotechnology
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DIO1 (T-20) - sc-69387 from Santa Cruz Biotechnology
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Anti-IOD1 antibody - N-terminal - ab175973 from Abcam
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Anti-DIO1 / TXDI1 Antibody (clone 1E4) - LS-C197052 from LifeSpan Bioscience
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Anti-DIO1 / TXDI1 Antibody (aa30-57, AP) - LS-C276638 from LifeSpan Bioscience
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Anti-DIO1 / TXDI1 Antibody (aa30-57, APC) - LS-C276640 from LifeSpan Bioscience
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Anti-DIO1 / TXDI1 Antibody (aa30-57, FITC) - LS-C276643 from LifeSpan Bioscience
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Anti-DIO1 / TXDI1 Antibody (aa30-57, Biotin) - LS-C276641 from LifeSpan Bioscience
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Anti-DIO1 / TXDI1 Antibody (aa30-57, Azide-free, HRP) - LS-C276644 from LifeSpan Bioscience
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Anti-DIO1 / TXDI1 Antibody (aa30-57, PE) - LS-C276645 from LifeSpan Bioscience
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Anti-DIO1 / TXDI1 Antibody (aa36-66) - LS-C327160 from LifeSpan Bioscience
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Anti-DIO1 / TXDI1 Antibody (aa30-57) - LS-C167416 from LifeSpan Bioscience
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DIO1 Antibody (1E4.) - H00001733-M01 from Novus Biologicals
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ANTI-DIO1 (N-TERM) antibody produced in rabbit - SAB1304992 from Sigma-Aldrich
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Monoclonal Anti-DIO1 antibody produced in mouse - SAB1402173 from Sigma-Aldrich
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DIO1-Antibody-N-term - AP6958a from Abgent, a WuXi AppTec company
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DIO1 Antibody - N-terminal region (OAAB04079) - OAAB04079 from Aviva Systems Biology
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DIO1 antibody, N-term - GTX81625 from GeneTex
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DIO1 (N-term) antibody - AP17281PU-N from Acris Antibodies
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Rabbit Anti-Human DIO1 (N-term) - 102-17037 from RayBiotech
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DIO1 antibody - 11790-1-AP from Proteintech Group
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DIO1 antibody (N-term) - STJ50323 from St John's Laboratory Ltd
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DIO1 Antibody - EPP12292 from Elabscience
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