| Gene Symbol |
YME1L1
|
| Entrez Gene |
10730
|
| Alt Symbol |
FTSH, MEG4, PAMP, YME1L
|
| Species |
Human
|
| Gene Type |
protein-coding
|
| Description |
YME1-like 1 ATPase
|
| Other Description |
ATP-dependent metalloprotease FtsH1 homolog|ATP-dependent metalloprotease YME1L1|ATP-dependent zinc metalloprotease YME1L1|YME1-like protein 1|meg-4|presenilin-associated metalloprotease
|
| Swissprots |
Q96TA2 Q9H1Q0 Q5T8D9 D3DRV8 Q9UMR9 D3DRV9 B4DNM1
|
| Accessions |
CAB99462 CBF59687 CBF67033 CBU84931 CBU91906 EAW86068 EAW86069 EAW86070 EAW86071 EAW86072 Q96TA2 AF018171 AAB70570 AF070656 AAD20962 AF151782 AAK57555 AI042625 AJ132637 CAB51858 AK001259 AK022930 AK291292 BAF83981 AK297973 BAG60283 AK309708 AK314372 AY358484 AAQ88848 BC007795 AAH07795 BC019602 AAH19602 BC023507 AAH23507 BC024032 AAH24032 DA395557 DA489399 XM_011519300 XP_011517602 NM_001253866 NP_001240795 NM_014263 NP_055078 NM_139312 NP_647473 NM_139313
|
| Function |
Putative ATP-dependent protease which plays a role in mitochondrial protein metabolism. Ensures cell proliferation, maintains normal cristae morphology and complex I respiration activity, promotes antiapoptotic activity and protects mitochondria from the accumulation of oxidatively damaged membrane proteins. Requires to control the accumulation of nonassembled respiratory chain subunits (NDUFB6, OX4 and ND1). Seems to act in the processing of OPA1. {ECO:0000269|PubMed:18076378, ECO:0000269|PubMed:22262461}.
|
| Subcellular Location |
Mitochondrion inner membrane {ECO:0000269|PubMed:10843804, ECO:0000269|PubMed:22262461}.
|
| Tissue Specificity |
High expression in cardiac and skeletal muscle mitochondria. {ECO:0000269|PubMed:22262461}.
|