| Gene Symbol | SEC22B |
|---|---|
| Entrez Gene | 9554 |
| Alt Symbol | ERS-24, SEC22L1 |
| Species | Human |
| Gene Type | protein-coding |
| Description | SEC22 vesicle trafficking protein homolog B (S. cerevisiae) (gene/pseudogene) |
| Other Description | ER-Golgi SNARE of 24 kDa|SEC22 vesicle trafficking protein-like 1|SEC22 vesicle-trafficking protein homolog B|vesicle-trafficking protein SEC22b |
| Swissprots | A8K1G0 O75396 |
| Accessions | O75396 AA135767 AF047442 AAC39893 AI085383 AK289875 BAF82564 BC001364 AAH01364 BU741516 CD619408 DQ892584 ABM83510 DQ895801 ABM86727 NM_004892 NP_004883 |
| Function | SNARE involved in targeting and fusion of ER-derived transport vesicles with the Golgi complex as well as Golgi-derived retrograde transport vesicles with the ER. {ECO:0000269|PubMed:15272311}. |
| Subcellular Location | Endoplasmic reticulum membrane {ECO:0000250}; Single-pass type IV membrane protein {ECO:0000250}. Endoplasmic reticulum-Golgi intermediate compartment membrane {ECO:0000250}. Golgi apparatus, cis-Golgi network membrane {ECO:0000250}. Golgi apparatus, trans-Golgi network membrane {ECO:0000250}. Melanosome {ECO:0000269|PubMed:17081065}. Note=Concentrated most in the intermediate compartment/cis-Golgi network and the cis-Golgi cisternae 1 and 2. Greatly reduced in concentration at the trans end of the Golgi apparatus. Identified by mass spectrometry in melanosome fractions from stage I to stage IV. |
| Top Pathways | Phagosome, Legionellosis, SNARE interactions in vesicular transport |