Gene Symbol | SEC22B |
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Entrez Gene | 9554 |
Alt Symbol | ERS-24, SEC22L1 |
Species | Human |
Gene Type | protein-coding |
Description | SEC22 vesicle trafficking protein homolog B (S. cerevisiae) (gene/pseudogene) |
Other Description | ER-Golgi SNARE of 24 kDa|SEC22 vesicle trafficking protein-like 1|SEC22 vesicle-trafficking protein homolog B|vesicle-trafficking protein SEC22b |
Swissprots | A8K1G0 O75396 |
Accessions | O75396 AA135767 AF047442 AAC39893 AI085383 AK289875 BAF82564 BC001364 AAH01364 BU741516 CD619408 DQ892584 ABM83510 DQ895801 ABM86727 NM_004892 NP_004883 |
Function | SNARE involved in targeting and fusion of ER-derived transport vesicles with the Golgi complex as well as Golgi-derived retrograde transport vesicles with the ER. {ECO:0000269|PubMed:15272311}. |
Subcellular Location | Endoplasmic reticulum membrane {ECO:0000250}; Single-pass type IV membrane protein {ECO:0000250}. Endoplasmic reticulum-Golgi intermediate compartment membrane {ECO:0000250}. Golgi apparatus, cis-Golgi network membrane {ECO:0000250}. Golgi apparatus, trans-Golgi network membrane {ECO:0000250}. Melanosome {ECO:0000269|PubMed:17081065}. Note=Concentrated most in the intermediate compartment/cis-Golgi network and the cis-Golgi cisternae 1 and 2. Greatly reduced in concentration at the trans end of the Golgi apparatus. Identified by mass spectrometry in melanosome fractions from stage I to stage IV. |
Top Pathways | Phagosome, Legionellosis, SNARE interactions in vesicular transport |
SEC22B CRISPR/Cas9 KO Plasmid (h) - sc-402384 from Santa Cruz Biotechnology
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SEC22B HDR Plasmid (h) - sc-402384-HDR from Santa Cruz Biotechnology
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SEC22B Double Nickase Plasmid (h) - sc-402384-NIC from Santa Cruz Biotechnology
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SEC22B Double Nickase Plasmid (h2) - sc-402384-NIC-2 from Santa Cruz Biotechnology
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SEC22B CRISPR Activation Plasmid (h) - sc-402384-ACT from Santa Cruz Biotechnology
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SEC22B CRISPR Activation Plasmid (h2) - sc-402384-ACT-2 from Santa Cruz Biotechnology
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SEC22B Lentiviral Activation Particles (h) - sc-402384-LAC from Santa Cruz Biotechnology
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SEC22B Lentiviral Activation Particles (h2) - sc-402384-LAC-2 from Santa Cruz Biotechnology
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SEC22B siRNA (h) - sc-88456 from Santa Cruz Biotechnology
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SEC22B shRNA Plasmid (h) - sc-88456-SH from Santa Cruz Biotechnology
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SEC22B shRNA (h) Lentiviral Particles - sc-88456-V from Santa Cruz Biotechnology
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CompoZr® Knockout ZFN Kit - CKOZFN19028 from Sigma-Aldrich
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CompoZr® Knockout ZFN Kit, ZFN plasmid only - CKOZFND19028 from Sigma-Aldrich
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MISSION® 3′UTR Lenti GoClone™ - HUTR12489 from Sigma-Aldrich
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SEC22B siRNA (Human) - CRH6355 from Cohesion Biosciences
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SEC22B RNAi - H00009554-R01 from Novus Biologicals
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SEC22B - MBS8213434 from MyBioSource
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shRNA set against Human SEC22B (NM_004892.5) - SHH403748 from Creative biogene
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Human SEC22B siRNA - orb266857 from Biorbyt
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SEC22B shRNA Plasmid (Human) - CHH6355 from Cohesion Biosciences
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SEC22B miRNA 3'UTR clone - MiUTR3H-06449 from Creative biogene
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