Gsk3b

Gene Symbol Gsk3b
Entrez Gene 56637
Alt Symbol 7330414F15Rik, 8430431H08Rik, C86142, GSK-3, GSK-3beta, GSK3
Species Mouse
Gene Type protein-coding
Description glycogen synthase kinase 3 beta
Other Description GSK-3 beta|glycogen synthase kinase-3 beta|serine/threonine-protein kinase GSK3B
Swissprots Q9WV60
Accessions EDK97969 Q9WV60 AB066114 BAD86827 AF156099 AAD39258 AK005170 AK020183 AK021230 AK078822 AK088784 AK148995 AK154293 BAE32494 AK164048 AK170965 BAE42146 AK171482 BAE42483 AK186943 AK190946 BC006936 AAH06936 BC032976 BC060743 AAH60743 XM_006522425 XP_006522488 XM_006522426 XP_006522489 NM_019827 NP_062801
Function Constitutively active protein kinase that acts as a negative regulator in the hormonal control of glucose homeostasis, Wnt signaling and regulation of transcription factors and microtubules, by phosphorylating and inactivating glycogen synthase (GYS1 or GYS2), EIF2B, CTNNB1/beta-catenin, APC, AXIN1, DPYSL2/CRMP2, JUN, NFATC1/NFATC, MAPT/TAU and MACF1. Requires primed phosphorylation of the majority of its substrates. In skeletal muscle, contributes to insulin regulation of glycogen synthesis by phosphorylating and inhibiting GYS1 activity and hence glycogen synthesis. May also mediate the development of insulin resistance by regulating activation of transcription factors. Regulates protein synthesis by controlling the activity of initiation factor 2B (EIF2BE/EIF2B5) in the same manner as glycogen synthase. In Wnt signaling, GSK3B forms a multimeric complex with APC, AXIN1 and CTNNB1/beta-catenin and phosphorylates the N-terminus of CTNNB1 leading to its degradation mediated by ubiquiti
Subcellular Location Cytoplasm {ECO:0000250}. Nucleus {ECO:0000250}. Cell membrane {ECO:0000250}. Note=The phosphorylated form shows localization to cytoplasm and cell membrane. The MEMO1-RHOA-DIAPH1 signaling pathway controls localization of the phosphorylated form to the cell membrane (By similarity). {ECO:0000250}.
Top Pathways Insulin signaling pathway, Cell cycle, Basal cell carcinoma, PI3K-Akt signaling pathway, B cell receptor signaling pathway

Gsk3b Antibody (OASB01293) - OASB01293 from Aviva Systems Biology

Prices $365.00
Sizes 100 µg
Host Mouse
Clonality Monoclonal
Clone 5D6

Gsk3b Antibody : SEPH (OASB01294) - OASB01294 from Aviva Systems Biology

Prices $493.00
Sizes 50 tests
Host Mouse
Clonality Monoclonal
Clone 5D6

Gsk3b Antibody (OASB01295) - OASB01295 from Aviva Systems Biology

Prices $348.00
Sizes 100 µg
Host Mouse
Clonality Monoclonal
Clone 3A11

Gsk3b Antibody : HRP (OASB01296) - OASB01296 from Aviva Systems Biology

Prices $418.00
Sizes 1 ml
Host Mouse
Clonality Monoclonal
Clone 3A11

Mouse-Gsk3b-Antibody-N-term - AP14847a from Abgent, a WuXi AppTec company

Prices $99.00, $295.00
Sizes 80 µl, 400 µl
Host Rabbit
Clonality Polyclonal
Mouse Gsk3b Antibody (N-term) (Cat. #AP14847a) western blot analysis in mouse NIH-3T3 cell line lysates (35ug/lane).This demonstrates the Gsk3b antibody detected the Gsk3b protein (arrow).

Mouse Gsk3b Antibody - N-terminal region (OAAB11178) - OAAB11178 from Aviva Systems Biology

Prices $289.00
Sizes 400 µl
Host Rabbit
Clonality Polyclonal

GSK3 beta antibody (Ser9) - 70R-37084 from Fitzgerald

Prices $295.00
Sizes 100 µg
Host Rabbit
Clonality Polyclonal

GSK3 beta antibody - 70R-34165 from Fitzgerald

Prices $275.00
Sizes 100 µg
Host Rabbit
Clonality Polyclonal

GSK3 beta antibody - 70R-37442 from Fitzgerald

Prices $225.00
Sizes 100 µg
Host Rabbit
Clonality Polyclonal

GSK3 beta antibody - 70R-30634 from Fitzgerald

Prices $275.00
Sizes 100 µg
Host Rabbit
Clonality Polyclonal

GSK3 beta antibody - 70R-34639 from Fitzgerald

Prices $275.00
Sizes 100 µg
Host Rabbit
Clonality Polyclonal

GSK3 beta antibody (Tyr216) - 70R-37352 from Fitzgerald

Prices $295.00
Sizes 100 µg
Host Rabbit
Clonality Polyclonal

Mouse Gsk3b Antibody - abx028354 from Abbexa

Host Rabbit
Clonality Polyclonal
Mouse Gsk3b Antibody (N-term) (Cat# 102-12683) western blot analysis in mouse NIH-3T3 cell line lysates (35ug/lane).This demonstrates the Gsk3b antibody detected the Gsk3b protein (arrow).

Gsk3b antibody (N-term) - STJ44387 from St John's Laboratory Ltd

Host Rabbit
Clonality Polyclonal
Clone RB34786

Gsk3b-phos(S389) antibody - 14850-1-AP from Proteintech Group

Host Rabbit
Clonality Polyclonal

GSK3-beta (clone 1F7), Antibody - GWB-12D342 from Genway Biotech

Prices $185.00, $310.00
Sizes 50 μl, 100 μl
Host Mouse
Clonality Monoclonal
Clone Anti-human GSK3? mAb, clone 1F7, is derived f

Mouse Anti-GSK-3, Antibody - GWB-6AC994 from Genway Biotech

Prices $678.00
Sizes 1 ml
Host Mouse
Clonality Monoclonal
Clone 3A11
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