| Gene Symbol |
Gsk3b
|
| Entrez Gene |
56637
|
| Alt Symbol |
7330414F15Rik, 8430431H08Rik, C86142, GSK-3, GSK-3beta, GSK3
|
| Species |
Mouse
|
| Gene Type |
protein-coding
|
| Description |
glycogen synthase kinase 3 beta
|
| Other Description |
GSK-3 beta|glycogen synthase kinase-3 beta|serine/threonine-protein kinase GSK3B
|
| Swissprots |
Q9WV60
|
| Accessions |
EDK97969 Q9WV60 AB066114 BAD86827 AF156099 AAD39258 AK005170 AK020183 AK021230 AK078822 AK088784 AK148995 AK154293 BAE32494 AK164048 AK170965 BAE42146 AK171482 BAE42483 AK186943 AK190946 BC006936 AAH06936 BC032976 BC060743 AAH60743 XM_006522425 XP_006522488 XM_006522426 XP_006522489 NM_019827 NP_062801
|
| Function |
Constitutively active protein kinase that acts as a negative regulator in the hormonal control of glucose homeostasis, Wnt signaling and regulation of transcription factors and microtubules, by phosphorylating and inactivating glycogen synthase (GYS1 or GYS2), EIF2B, CTNNB1/beta-catenin, APC, AXIN1, DPYSL2/CRMP2, JUN, NFATC1/NFATC, MAPT/TAU and MACF1. Requires primed phosphorylation of the majority of its substrates. In skeletal muscle, contributes to insulin regulation of glycogen synthesis by phosphorylating and inhibiting GYS1 activity and hence glycogen synthesis. May also mediate the development of insulin resistance by regulating activation of transcription factors. Regulates protein synthesis by controlling the activity of initiation factor 2B (EIF2BE/EIF2B5) in the same manner as glycogen synthase. In Wnt signaling, GSK3B forms a multimeric complex with APC, AXIN1 and CTNNB1/beta-catenin and phosphorylates the N-terminus of CTNNB1 leading to its degradation mediated by ubiquiti
|
| Subcellular Location |
Cytoplasm {ECO:0000250}. Nucleus {ECO:0000250}. Cell membrane {ECO:0000250}. Note=The phosphorylated form shows localization to cytoplasm and cell membrane. The MEMO1-RHOA-DIAPH1 signaling pathway controls localization of the phosphorylated form to the cell membrane (By similarity). {ECO:0000250}.
|
| Top Pathways |
Insulin signaling pathway, Cell cycle, Basal cell carcinoma, PI3K-Akt signaling pathway, B cell receptor signaling pathway
|
