| Gene Symbol |
NME8
|
| Entrez Gene |
51314
|
| Alt Symbol |
CILD6, NM23-H8, SPTRX2, TXNDC3, sptrx-2
|
| Species |
Human
|
| Gene Type |
protein-coding
|
| Description |
NME/NM23 family member 8
|
| Other Description |
sperm-specific thioredoxin 2|spermatid-specific thioredoxin-2|thioredoxin domain containing 3 (spermatozoa)|thioredoxin domain-containing protein 3
|
| Swissprots |
Q8N427 Q9NZH1
|
| Accessions |
EAW94083 EAW94084 Q8N427 AF202051 AAF20909 AF305596 AAN04258 AK313599 BAG36365 BC036816 AAH36816 JF432242 ADZ15459 NM_016616 NP_057700
|
| Function |
Probably required during the final stages of sperm tail maturation in the testis and/or epididymis, where extensive disulfide bonding of fibrous sheath (FS) proteins occurs. May be involved in the reduction of disulfide bonds within the sperm FS components. In vitro, it has neither NDP kinase nor reducing activity on disulfide bonds.
|
| Subcellular Location |
Cytoplasm {ECO:0000269|PubMed:11737268}.
|
| Tissue Specificity |
Testis-specific. Expressed only in primary spermatocytes and round spermatids. {ECO:0000269|PubMed:11737268}.
|