PALB2

Gene Symbol	PALB2
Entrez Gene	79728
Alt Symbol	FANCN, PNCA3
Species	Human
Gene Type	protein-coding
Description	partner and localizer of BRCA2
Other Description	-
Swissprots	Q9H6W1 Q8N7Y6 Q8ND31 A6NIE1 Q86YC2
Accessions	CAS97368 EAW55811 EAW55812 EAW55813 Q86YC2 AK025469 BAB15140 AK097533 BAC05090 AK299152 BAG61201 AL834425 CAD39086 BC044254 AAH44254 BE670820 BX647125 BX647130 CR749637 CAH18431 DA192828 EU831610 ACE87210 EU831697 ACE86531 XM_011545946 XP_011544248 XM_011545947 XP_011544249 XM_011545948 XP_011544250 XR_950851 NM_024675 NP_078951
Function	Plays a critical role in homologous recombination repair (HRR) through its ability to recruit BRCA2 and RAD51 to DNA breaks. Strongly stimulates the DNA strand-invasion activity of RAD51, stabilizes the nucleoprotein filament against a disruptive BRC3-BRC4 polypeptide and helps RAD51 to overcome the suppressive effect of replication protein A (RPA). Functionally cooperates with RAD51AP1 in promoting of D-loop formation by RAD51. Serves as the molecular scaffold in the formation of the BRCA1-PALB2-BRCA2 complex which is essential for homologous recombination. Via its WD repeats is proposed to scaffold a HR complex containing RAD51C and BRCA2 which is thought to play a role in HR-mediated DNA repair. Essential partner of BRCA2 that promotes the localization and stability of BRCA2. Also enables its recombinational repair and checkpoint functions of BRCA2. May act by promoting stable association of BRCA2 with nuclear structures, allowing BRCA2 to escape the effects of proteasome-mediated d
Subcellular Location	Nucleus {ECO:0000269|PubMed:16793542}. Note=Colocalizes with BRCA2 in nuclear foci.
Top Pathways	Fanconi anemia pathway

• Antibodies
• Assays/Kits
• Proteins/Peptides
• siRNAs/Functional Genomics
• cDNA Clones
• Cell/Tissue/Blood Products

Human PALB2 peptide - ab38740 from Abcam Category Peptide

Human PALB2 peptide - ab38741 from Abcam Category Peptide

PALB2 Antibody Blocking Peptide - LS-E1155 from LifeSpan Bioscience Category Peptide Prices $145.00 Sizes 100 µg

PALB2 Antibody Blocking Peptide - LS-E30746 from LifeSpan Bioscience Category Peptide Prices $145.00 Sizes 50 µg

PALB2 Antibody Blocking Peptide - LS-E23258 from LifeSpan Bioscience Category Peptide Prices $145.00 Sizes 100 µg

PALB2 Blocking Peptide - NBP1-76317PEP from Novus Biologicals Category Peptide Prices $129.00 Sizes 50 µg Species Human

PALB2-Antibody-Center-Blocking-peptide - BP11688c from Abgent, a WuXi AppTec company Category Peptide Prices $80.00 Sizes 100 µg

PALB2 Peptide - GTX85263-PEP from GeneTex Category Peptide Prices $149.00 Sizes 50 μg Species Human

PALB2 control peptide - AP10193CP-N from Acris Antibodies Category Peptide Prices $235.00 Sizes 100 µg

PALB2 Control Peptide - AP30645CP-N from Acris Antibodies Category Peptide Prices $135.00 Sizes 50 µg

PALB2 Peptide - 5275P from ProSci Category Peptide Species Human

PALB2 fusion protein - Ag5654 from Proteintech Group Category Protein Prices $199.00 Sizes 50 μg Source E. coli -derived, PGEX-4T Species Human

PALB2 fusion protein - ag5995 from Proteintech Group Category Protein Source E. coli-derived, PET28a Species Human

Recombinant Human PALB2, GST-tagged - PALB2-1516H from Creative Biomart Category Protein Source E.coli Species Human

Recombinant Human Partner and localizer of BRCA2(PALB2) ,partial - CSB-YP017411HU CSB-EP017411HU CSB-BP017411HU CSB-MP017411HU from Cusabio Category Protein Source Yeast or E.coli or Baculovirus or Mammalian cell Species Human

PALB2 Protein - abx163214 from Abbexa Category Protein Species Human

Partner and localizer of BRCA2 (PALB2), partial, Recombinant Protein - MBS1456388 from MyBioSource Category Protein Source E Coli or Yeast or Baculovirus or Mammalian Cell Species Human

PALB2 protein - orb86191 from Biorbyt Category Protein Prices $238.00 Sizes 500 µg

PALB2 Peptide, Human - M34GP11267H from Creative Peptides Category Peptide Source Synthetic. Species Human

PALB2 Recombinant Protein Antigen - NBP2-55028PEP from Novus Biologicals Category Protein Prices $199.00 Sizes 100 µl Source E.coli Species Human

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