PALB2

Gene Symbol PALB2
Entrez Gene 79728
Alt Symbol FANCN, PNCA3
Species Human
Gene Type protein-coding
Description partner and localizer of BRCA2
Other Description -
Swissprots Q9H6W1 Q8N7Y6 Q8ND31 A6NIE1 Q86YC2
Accessions CAS97368 EAW55811 EAW55812 EAW55813 Q86YC2 AK025469 BAB15140 AK097533 BAC05090 AK299152 BAG61201 AL834425 CAD39086 BC044254 AAH44254 BE670820 BX647125 BX647130 CR749637 CAH18431 DA192828 EU831610 ACE87210 EU831697 ACE86531 XM_011545946 XP_011544248 XM_011545947 XP_011544249 XM_011545948 XP_011544250 XR_950851 NM_024675 NP_078951
Function Plays a critical role in homologous recombination repair (HRR) through its ability to recruit BRCA2 and RAD51 to DNA breaks. Strongly stimulates the DNA strand-invasion activity of RAD51, stabilizes the nucleoprotein filament against a disruptive BRC3-BRC4 polypeptide and helps RAD51 to overcome the suppressive effect of replication protein A (RPA). Functionally cooperates with RAD51AP1 in promoting of D-loop formation by RAD51. Serves as the molecular scaffold in the formation of the BRCA1-PALB2-BRCA2 complex which is essential for homologous recombination. Via its WD repeats is proposed to scaffold a HR complex containing RAD51C and BRCA2 which is thought to play a role in HR-mediated DNA repair. Essential partner of BRCA2 that promotes the localization and stability of BRCA2. Also enables its recombinational repair and checkpoint functions of BRCA2. May act by promoting stable association of BRCA2 with nuclear structures, allowing BRCA2 to escape the effects of proteasome-mediated d
Subcellular Location Nucleus {ECO:0000269|PubMed:16793542}. Note=Colocalizes with BRCA2 in nuclear foci.
Top Pathways Fanconi anemia pathway

PALB2 (C-13) - sc-160646 from Santa Cruz Biotechnology

Prices $279.00
Sizes 200 µg/ml
Host Goat
Clonality Polyclonal

PALB2 (G-13) - sc-160647 from Santa Cruz Biotechnology

Prices $279.00
Sizes 200 µg/ml
Host Goat
Clonality Polyclonal
PALB2 (G-13): sc-160647. Western blot analysis of PALB2 expression in mouse brain tissue extract.

PALB2 (H-45) - sc-382436 from Santa Cruz Biotechnology

Prices $279.00
Sizes 200 µg/ml
Host Rabbit
Clonality Polyclonal

Anti-PALB2 antibody - ab170513 from Abcam

Prices $370.00
Sizes 400 µl
Host Rabbit
Clonality Polyclonal
Flow cytometric analysis of HepG2 cells labeling PALB2 with ab170513 at 1/10 dilution (right histogram) compared to a negative control cell (left histogram). FITC-conjugated goat-anti-rabbit secondary antibodies was used for the analysis.

Anti-PALB2 antibody - ab86871 from Abcam

Host Rabbit
Clonality Polyclonal

Anti-PALB2 antibody - ab38587 from Abcam

Prices $242.00
Sizes 100 µg
Host Rabbit
Clonality Polyclonal

Anti-PALB2 antibody - ab38742 from Abcam

Prices $242.00
Sizes 100 µg
Host Rabbit
Clonality Polyclonal

Anti-PALB2 Antibody (aa675-725) - LS-C93000 from LifeSpan Bioscience

Prices $545.00
Sizes 100 µg
Host Rabbit
Clonality Polyclonal

Anti-PALB2 Antibody (aa200-250) - LS-C92999 from LifeSpan Bioscience

Prices $545.00
Sizes 100 µg
Host Rabbit
Clonality Polyclonal

Anti-PALB2 Antibody (aa546-574, AP) - LS-C265521 from LifeSpan Bioscience

Prices $545.00
Sizes 200 µl
Host Rabbit
Clonality Polyclonal

Anti-PALB2 Antibody (aa546-574, APC) - LS-C265522 from LifeSpan Bioscience

Prices $545.00
Sizes 200 µl
Host Rabbit
Clonality Polyclonal

Anti-PALB2 Antibody (aa546-574, Biotin) - LS-C265523 from LifeSpan Bioscience

Prices $545.00
Sizes 200 µl
Host Rabbit
Clonality Polyclonal

Anti-PALB2 Antibody (aa546-574, FITC) - LS-C265524 from LifeSpan Bioscience

Prices $545.00
Sizes 200 µl
Host Rabbit
Clonality Polyclonal

Anti-PALB2 Antibody (aa546-574, Azide-free, HRP) - LS-C265525 from LifeSpan Bioscience

Prices $545.00
Sizes 200 µl
Host Rabbit
Clonality Polyclonal

Anti-PALB2 Antibody (aa546-574, PE) - LS-C265526 from LifeSpan Bioscience

Prices $545.00
Sizes 200 µl
Host Rabbit
Clonality Polyclonal

Anti-PALB2 Antibody (aa553-582) - LS-C323766 from LifeSpan Bioscience

Prices $345.00
Sizes 200 µl
Host Rabbit
Clonality Polyclonal

Anti-PALB2 Antibody - LS-C343710 from LifeSpan Bioscience

Prices $385.00
Sizes 100 µg
Host Rabbit
Clonality Polyclonal

Anti-PALB2 Antibody (aa677-726) - LS-C146550 from LifeSpan Bioscience

Prices $365.00
Sizes 50 µg
Host Rabbit
Clonality Polyclonal
PALB2 antibody LS-C146550 Western blot of HeLa Cell lysate. Antibody concentration 1 ug/ml.

Anti-PALB2 Antibody (C-Terminus) - LS-C108560 from LifeSpan Bioscience

Prices $325.00, $890.00
Sizes 100 µg, 500 µg
Host Rabbit
Clonality Polyclonal
Western blot of PALB2 in SK-N-SH cell lysate with PALB2 antibody at (A) 1 and (B) 2 ug/ml.

Anti-PALB2 Antibody (aa546-574) - LS-C163349 from LifeSpan Bioscience

Prices $295.00
Sizes 400 µl
Host Rabbit
Clonality Polyclonal
PALB2 Antibody western blot of HepG2 cell line lysates (35 ug/lane). The PALB2 antibody detected the PALB2 protein (arrow).

Anti-PALB2 Antibody (aa200-250) - LS-C286498 from LifeSpan Bioscience

Prices $415.00
Sizes 100 µl
Host Rabbit
Clonality Polyclonal
Detection of Human PALB2 by Immunohistochemistry. Sample: FFPE section of human breast carcinoma. Antibody: Affinity purified rabbit anti-PALB2 used at a dilution of 1:250.

Anti-PALB2 Antibody (aa675-725) IHC-plus™ - LS-B11898 from LifeSpan Bioscience

Prices $395.00
Sizes 50 µl
Host Rabbit
Clonality Polyclonal
Human Thyroid: Formalin-Fixed, Paraffin-Embedded (FFPE)

Anti-PALB2 Antibody (aa200-250) - LS-C288057 from LifeSpan Bioscience

Prices $375.00
Sizes 100 µl
Host Rabbit
Clonality Polyclonal
Detection of Human PALB2 by Immunohistochemistry. Sample: FFPE section of human breast carcinoma. Antibody: Affinity purified rabbit anti-PALB2 used at a dilution of 1:5000 (0.2 ug/ml). Detection: DAB.

PALB2 Antibody - NB100-60439 from Novus Biologicals

Prices $359.00
Sizes 100 µl
Host Rabbit
Clonality Polyclonal
Western Blot: PALB2 Antibody [NB100-60439] - Detection of Human PALB2 on HeLa whole cell lysate using NB100-60439. PALB2 was also immunoprecipitated by rabbit anti-PALB2 antibody NB100-60440.

PALB2 Antibody - 21340002 from Novus Biologicals

Prices $329.00
Sizes 100 µg
Host Rabbit
Clonality Polyclonal
Western Blot: PALB2 Antibody [21340002] - Western Blot was performed using affinity purified SEQer PALB2 antibody, aa(99-198) antibody. The lanes contain 5-30ug of a whole cell extract. Final concentration of antibodies = 0.1ug/ml (1:10,000 dilution). The blot was probed overnight with the SEQer PALB2 antibody, aa(99-198) antibody. Blot was then washed according to protocol and probed with goat-anti-Rabbit-HRP conjugate at 1:5000 dilution, washed and developed using chemiluminescence (film exposure 5-30sec). The protein was detected as represented by the band shown.
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