| Gene Symbol | EIF3D |
|---|---|
| Entrez Gene | 8664 |
| Alt Symbol | EIF3S7, eIF3-p66, eIF3-zeta |
| Species | Human |
| Gene Type | protein-coding |
| Description | eukaryotic translation initiation factor 3, subunit D |
| Other Description | eIF3 p66|eukaryotic translation initiation factor 3 subunit D|eukaryotic translation initiation factor 3, subunit 7 zeta, 66/67kDa|translation initiation factor eIF3 p66 subunit |
| Swissprots | B2R7D4 Q3MJD9 B4DTF8 A8MWD3 O15371 Q5M9Q6 B4DVY1 |
| Accessions | EAW60109 EAW60110 O15371 AK300199 BAG61970 AK301284 BAG62843 AK303884 BAG64820 AK312939 BAG35781 AW575097 BC000328 AAH00328 BC000469 AAH00469 BC014912 AAH14912 BC080515 AAH80515 BC093100 AAH93100 BC093686 AAH93686 BC101477 AAI01478 BG718662 BT007381 AAP36045 CR456489 CAG30375 CU013049 CAK54480 CU013337 CAK54779 DQ891129 ABM82055 DQ894308 ABM85234 U54558 AAD03466 XM_011530479 XP_011528781 XR_937944 NM_003753 NP_003744 |
| Function | Component of the eukaryotic translation initiation factor 3 (eIF-3) complex, which is required for several steps in the initiation of protein synthesis. The eIF-3 complex associates with the 40S ribosome and facilitates the recruitment of eIF-1, eIF-1A, eIF-2:GTP:methionyl-tRNAi and eIF-5 to form the 43S preinitiation complex (43S PIC). The eIF-3 complex stimulates mRNA recruitment to the 43S PIC and scanning of the mRNA for AUG recognition. The eIF-3 complex is also required for disassembly and recycling of post-termination ribosomal complexes and subsequently prevents premature joining of the 40S and 60S ribosomal subunits prior to initiation. |
| Subcellular Location | Cytoplasm {ECO:0000255|HAMAP-Rule:MF_03003}. |
| Top Pathways | RNA transport |