Gene Symbol | ENTPD2 |
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Entrez Gene | 954 |
Alt Symbol | CD39L1, NTPDase-2 |
Species | Human |
Gene Type | protein-coding |
Description | ectonucleoside triphosphate diphosphohydrolase 2 |
Other Description | CD39 antigen-like 1|NTPDase 2|ecto-ATP diphosphohydrolase 2|ecto-ATPDase 2|ecto-ATPase 2 |
Swissprots | Q5SPY7 Q9Y5L3 Q5SPY6 O15464 |
Accessions | EAW88336 EAW88337 Q9Y5L3 AF144748 AAD40239 BC011003 BC035738 AAH35738 BQ883059 CB045339 DQ892410 ABM83336 DQ895623 ABM86549 EF495152 ABP58644 U91510 AAB81013 XM_011519211 XP_011517513 XM_011519212 XP_011517514 NM_001246 NP_001237 NM_203468 NP_982293 |
Function | In the nervous system, could hydrolyze ATP and other nucleotides to regulate purinergic neurotransmission. Hydrolyzes ADP only to a marginal extent. The order of activity with different substrates is ATP > GTP > CTP = ITP > UTP >> ADP = UDP. |
Subcellular Location | Isoform gamma: Endoplasmic reticulum membrane; Multi-pass membrane protein. |
Tissue Specificity | Brain, placenta, skeletal muscle, kidney, pancreas, heart, ovary, testis, colon, small intestine, prostate and pancreas. No expression in adult thymus, spleen, lung, liver and peripheral blood leukocytes. |
Top Pathways | Purine metabolism |
CD39L1 CRISPR/Cas9 KO Plasmid (h) - sc-405579 from Santa Cruz Biotechnology
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CD39L1 HDR Plasmid (h) - sc-405579-HDR from Santa Cruz Biotechnology
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CD39L1 Double Nickase Plasmid (h) - sc-405579-NIC from Santa Cruz Biotechnology
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CD39L1 Double Nickase Plasmid (h2) - sc-405579-NIC-2 from Santa Cruz Biotechnology
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CD39L1 CRISPR Activation Plasmid (h) - sc-405579-ACT from Santa Cruz Biotechnology
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CD39L1 CRISPR Activation Plasmid (h2) - sc-405579-ACT-2 from Santa Cruz Biotechnology
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CD39L1 Lentiviral Activation Particles (h) - sc-405579-LAC from Santa Cruz Biotechnology
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CD39L1 Lentiviral Activation Particles (h2) - sc-405579-LAC-2 from Santa Cruz Biotechnology
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CD39L1 siRNA (h) - sc-92708 from Santa Cruz Biotechnology
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CD39L1 shRNA Plasmid (h) - sc-92708-SH from Santa Cruz Biotechnology
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CD39L1 shRNA (h) Lentiviral Particles - sc-92708-V from Santa Cruz Biotechnology
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CD39L1/ENTPD2 RNAi - H00000954-R04 from Novus Biologicals
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CD39L1/ENTPD2 RNAi - H00000954-R03 from Novus Biologicals
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MISSION® esiRNA - EHU061021 from Sigma-Aldrich
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MISSION® Human Phosphatase - SIHP0186 from Sigma-Aldrich
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MISSION® Human Phosphatase - SIHP0185 from Sigma-Aldrich
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MISSION® Human Phosphatase - SIHP0184 from Sigma-Aldrich
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MISSION® Human Phosphatase - SIHP0954 from Sigma-Aldrich
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CompoZr® Knockout ZFN Kit - CKOZFN7890 from Sigma-Aldrich
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CompoZr® Knockout ZFN Kit, ZFN plasmid only - CKOZFND7890 from Sigma-Aldrich
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ENTPD2 siRNA (Human) - CRH0676 from Cohesion Biosciences
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ENTPD2 - MBS8201333 from MyBioSource
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shRNA set against Human ENTPD2 (NM_001246.3) - SHH286037 from Creative biogene
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Human ENTPD2 siRNA - orb261178 from Biorbyt
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ENTPD2 shRNA Plasmid (Human) - CHH0676 from Cohesion Biosciences
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