Gene Symbol | GNGT2 |
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Entrez Gene | 2793 |
Alt Symbol | G-GAMMA-8, G-GAMMA-C, GNG8, GNG9, GNGT8 |
Species | Human |
Gene Type | protein-coding |
Description | guanine nucleotide binding protein (G protein), gamma transducing activity polypeptide 2 |
Other Description | G protein cone gamma 8 subunit|G-gamma-9|g gamma-C|gamma-T2 subunit|guanine nucleotide binding protein gamma 9|guanine nucleotide binding protein gamma transducing activity polypeptide 2|guanine nucleotide-binding protein G(I)/G(S)/G(O) subunit gamma-T2 |
Swissprots | B2R746 D3DTW5 O14610 |
Accessions | AAB70039 EAW94688 EAW94689 O14610 AF365870 AAK53384 AF493876 AAM12590 AI857683 AK312839 BAG35693 BC008663 AAH08663 BM723861 BU742490 DA248836 HQ448708 ADQ33186 XM_006721819 XP_006721882 NM_001198754 NP_001185683 NM_001198755 NP_001185684 NM_001198756 NP_001185685 NM_031498 NP_113686 |
Function | Guanine nucleotide-binding proteins (G proteins) are involved as a modulator or transducer in various transmembrane signaling systems. The beta and gamma chains are required for the GTPase activity, for replacement of GDP by GTP, and for G protein- effector interaction. |
Subcellular Location | Cell membrane {ECO:0000305}; Lipid-anchor {ECO:0000305}; Cytoplasmic side {ECO:0000305}. |
Tissue Specificity | Retinal cones. |
Top Pathways | Dopaminergic synapse, Morphine addiction, Glutamatergic synapse, PI3K-Akt signaling pathway, GABAergic synapse |
GNGT2 CRISPR/Cas9 KO Plasmid (h) - sc-410798 from Santa Cruz Biotechnology
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GNGT2 HDR Plasmid (h) - sc-410798-HDR from Santa Cruz Biotechnology
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GNGT2 Double Nickase Plasmid (h) - sc-410798-NIC from Santa Cruz Biotechnology
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GNGT2 Double Nickase Plasmid (h2) - sc-410798-NIC-2 from Santa Cruz Biotechnology
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GNGT2 CRISPR Activation Plasmid (h) - sc-410798-ACT from Santa Cruz Biotechnology
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GNGT2 CRISPR Activation Plasmid (h2) - sc-410798-ACT-2 from Santa Cruz Biotechnology
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GNGT2 Lentiviral Activation Particles (h) - sc-410798-LAC from Santa Cruz Biotechnology
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GNGT2 Lentiviral Activation Particles (h2) - sc-410798-LAC-2 from Santa Cruz Biotechnology
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GNGT2 siRNA (h) - sc-94076 from Santa Cruz Biotechnology
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GNGT2 shRNA Plasmid (h) - sc-94076-SH from Santa Cruz Biotechnology
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GNGT2 shRNA (h) Lentiviral Particles - sc-94076-V from Santa Cruz Biotechnology
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G gamma14 RNAi - H00002793-R01 from Novus Biologicals
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CompoZr® Knockout ZFN Kit - CKOZFN9434 from Sigma-Aldrich
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CompoZr® Knockout ZFN Kit, ZFN plasmid only - CKOZFND9434 from Sigma-Aldrich
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MISSION® 3′UTR Lenti GoClone™ - HUTR04010 from Sigma-Aldrich
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GNGT2 siRNA (Human) - CRH1864 from Cohesion Biosciences
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GNGT2 - MBS8217281 from MyBioSource
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shRNA set against Human GNGT2 (NM_031498.2) - SHH304958 from Creative biogene
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Human GNGT2 siRNA - orb262366 from Biorbyt
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GNGT2 shRNA Plasmid (Human) - CHH1864 from Cohesion Biosciences
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GNGT2 miRNA 3'UTR clone - MiUTR4H-TG03889 from Creative biogene
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