| Gene Symbol |
Papss2
|
| Entrez Gene |
23972
|
| Alt Symbol |
1810018P12Rik, AI159688, AtpsU2, Atpsk2, Sk2, bm
|
| Species |
Mouse
|
| Gene Type |
protein-coding
|
| Description |
3'-phosphoadenosine 5'-phosphosulfate synthase 2
|
| Other Description |
PAPS synthase 2|PAPSS 2|SK 2|bifunctional 3'-phosphoadenosine 5'-phosphosulfate synthase 2|brachymorphic|sulfurylase kinase 2
|
| Swissprots |
Q9Z274 Q5BKP4 O88428
|
| Accessions |
AAF12760 EDL41726 O88428 AF052453 AAC40191 AF085144 AAC98687 AK007539 AK029185 AK128962 AK137675 BC090997 AAH90997 BY224664 XM_006527064 XP_006527127 XM_006527065 XP_006527128 NM_001201470 NP_001188399 NM_011864 NP_035994
|
| Function |
Bifunctional enzyme with both ATP sulfurylase and APS kinase activity, which mediates two steps in the sulfate activation pathway. The first step is the transfer of a sulfate group to ATP to yield adenosine 5'-phosphosulfate (APS), and the second step is the transfer of a phosphate group from ATP to APS yielding 3'-phosphoadenylylsulfate (PAPS: activated sulfate donor used by sulfotransferase). In mammals, PAPS is the sole source of sulfate; APS appears to be only an intermediate in the sulfate- activation pathway. May have a important role in skeletogenesis during postnatal growth.
|
| Tissue Specificity |
Expressed in liver, cartilage, skin and brain.
|
| Top Pathways |
Sulfur metabolism, Purine metabolism, Selenocompound metabolism
|