Gene Symbol | Papss2 |
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Entrez Gene | 23972 |
Alt Symbol | 1810018P12Rik, AI159688, AtpsU2, Atpsk2, Sk2, bm |
Species | Mouse |
Gene Type | protein-coding |
Description | 3'-phosphoadenosine 5'-phosphosulfate synthase 2 |
Other Description | PAPS synthase 2|PAPSS 2|SK 2|bifunctional 3'-phosphoadenosine 5'-phosphosulfate synthase 2|brachymorphic|sulfurylase kinase 2 |
Swissprots | Q9Z274 Q5BKP4 O88428 |
Accessions | AAF12760 EDL41726 O88428 AF052453 AAC40191 AF085144 AAC98687 AK007539 AK029185 AK128962 AK137675 BC090997 AAH90997 BY224664 XM_006527064 XP_006527127 XM_006527065 XP_006527128 NM_001201470 NP_001188399 NM_011864 NP_035994 |
Function | Bifunctional enzyme with both ATP sulfurylase and APS kinase activity, which mediates two steps in the sulfate activation pathway. The first step is the transfer of a sulfate group to ATP to yield adenosine 5'-phosphosulfate (APS), and the second step is the transfer of a phosphate group from ATP to APS yielding 3'-phosphoadenylylsulfate (PAPS: activated sulfate donor used by sulfotransferase). In mammals, PAPS is the sole source of sulfate; APS appears to be only an intermediate in the sulfate- activation pathway. May have a important role in skeletogenesis during postnatal growth. |
Tissue Specificity | Expressed in liver, cartilage, skin and brain. |
Top Pathways | Sulfur metabolism, Purine metabolism, Selenocompound metabolism |
PAPSS 2 CRISPR/Cas9 KO Plasmid (m) - sc-423928 from Santa Cruz Biotechnology
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PAPSS 2 HDR Plasmid (m) - sc-423928-HDR from Santa Cruz Biotechnology
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PAPSS 2 Double Nickase Plasmid (m) - sc-423928-NIC from Santa Cruz Biotechnology
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PAPSS 2 Double Nickase Plasmid (m2) - sc-423928-NIC-2 from Santa Cruz Biotechnology
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PAPSS 2 CRISPR Activation Plasmid (m) - sc-423928-ACT from Santa Cruz Biotechnology
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PAPSS 2 CRISPR Activation Plasmid (m2) - sc-423928-ACT-2 from Santa Cruz Biotechnology
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PAPSS 2 Lentiviral Activation Particles (m) - sc-423928-LAC from Santa Cruz Biotechnology
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PAPSS 2 Lentiviral Activation Particles (m2) - sc-423928-LAC-2 from Santa Cruz Biotechnology
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PAPSS 2 siRNA (m) - sc-61294 from Santa Cruz Biotechnology
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PAPSS 2 shRNA Plasmid (m) - sc-61294-SH from Santa Cruz Biotechnology
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PAPSS 2 shRNA (m) Lentiviral Particles - sc-61294-V from Santa Cruz Biotechnology
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CompoZr® Knockout ZFN Kit - CKOZFN38244 from Sigma-Aldrich
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CompoZr® Knockout ZFN Kit, ZFN plasmid only - CKOZFND38244 from Sigma-Aldrich
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PAPSS2 siRNA (Mouse) - CRM4612 from Cohesion Biosciences
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shRNA set against Mouse Pap (NM_011864.3) - SHH370440 from Creative biogene
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shRNA set against Mouse Papss2(NM_011864.3) - SHR087482 from Creative biogene
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Mouse PAPSS2 siRNA - orb284088 from Biorbyt
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PAPSS2 shRNA Plasmid (Mouse) - CHM4612 from Cohesion Biosciences
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PAPSS2 miRNA 3'UTR clone - MiUTR1M-08891 from Creative biogene
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