| Gene Symbol | Papss2 |
|---|---|
| Entrez Gene | 23972 |
| Alt Symbol | 1810018P12Rik, AI159688, AtpsU2, Atpsk2, Sk2, bm |
| Species | Mouse |
| Gene Type | protein-coding |
| Description | 3'-phosphoadenosine 5'-phosphosulfate synthase 2 |
| Other Description | PAPS synthase 2|PAPSS 2|SK 2|bifunctional 3'-phosphoadenosine 5'-phosphosulfate synthase 2|brachymorphic|sulfurylase kinase 2 |
| Swissprots | Q9Z274 Q5BKP4 O88428 |
| Accessions | AAF12760 EDL41726 O88428 AF052453 AAC40191 AF085144 AAC98687 AK007539 AK029185 AK128962 AK137675 BC090997 AAH90997 BY224664 XM_006527064 XP_006527127 XM_006527065 XP_006527128 NM_001201470 NP_001188399 NM_011864 NP_035994 |
| Function | Bifunctional enzyme with both ATP sulfurylase and APS kinase activity, which mediates two steps in the sulfate activation pathway. The first step is the transfer of a sulfate group to ATP to yield adenosine 5'-phosphosulfate (APS), and the second step is the transfer of a phosphate group from ATP to APS yielding 3'-phosphoadenylylsulfate (PAPS: activated sulfate donor used by sulfotransferase). In mammals, PAPS is the sole source of sulfate; APS appears to be only an intermediate in the sulfate- activation pathway. May have a important role in skeletogenesis during postnatal growth. |
| Tissue Specificity | Expressed in liver, cartilage, skin and brain. |
| Top Pathways | Sulfur metabolism, Purine metabolism, Selenocompound metabolism |