GNAI1

Gene Symbol GNAI1
Entrez Gene 2770
Alt Symbol Gi
Species Human
Gene Type protein-coding
Description guanine nucleotide binding protein (G protein), alpha inhibiting activity polypeptide 1
Other Description Gi1 protein alpha subunit|adenylate cyclase-inhibiting G alpha protein|guanine nucleotide-binding protein G(i) subunit alpha-1
Swissprots Q9UGA4 C9J3A4 P63096 B4E2V1 A8KA88 P11015 P31871 P04898 Q8TAN5 Q5U074
Accessions AAA35893 AAC03418 EAW77009 EAW77010 EAW77011 EAW77012 P63096 AF055013 AAC09361 AF493905 AAM12619 AI878901 AK292953 BAF85642 AK304442 BAG65263 AL049933 CAB43212 AM393657 CAL38533 BC026326 AAH26326 BT019775 AAV38580 CD299597 DQ892385 ABM83311 DQ895598 ABM86524 DQ895599 ABM86525 M17219 AAA52581 NM_001256414 NP_001243343 NM_002069 NP_002060
Function Guanine nucleotide-binding proteins (G proteins) are involved as modulators or transducers in various transmembrane signaling systems. The G(i) proteins are involved in hormonal regulation of adenylate cyclase: they inhibit the cyclase in response to beta-adrenergic stimuli. The inactive GDP-bound form prevents the association of RGS14 with centrosomes and is required for the translocation of RGS14 from the cytoplasm to the plasma membrane. May play a role in cell division. {ECO:0000269|PubMed:17264214, ECO:0000269|PubMed:17635935}.
Subcellular Location Nucleus {ECO:0000250}. Cytoplasm {ECO:0000269|PubMed:17635935}. Cell membrane {ECO:0000269|PubMed:17635935}. Cytoplasm, cytoskeleton, microtubule organizing center, centrosome {ECO:0000269|PubMed:17635935}. Note=Localized at the plasma membrane throughout mitosis. Colocalizes with RIC8A and RGS14 at the plasma membrane (By similarity). Localizes in the centrosomes of interphase and mitotic cells, but not in centrosomes during cytokinesis. Detected at the cleavage furrow or the midbody. {ECO:0000250}.
Top Pathways Circadian entrainment, Oxytocin signaling pathway, Estrogen signaling pathway, Adrenergic signaling in cardiomyocytes, Glutamatergic synapse

G α i-1 CRISPR/Cas9 KO Plasmid (h) - sc-400652 from Santa Cruz Biotechnology

Category CRISPR
Prices $345.00
Sizes 20 µg
Species Reactivities Human

G α i-1 HDR Plasmid (h) - sc-400652-HDR from Santa Cruz Biotechnology

Prices $345.00
Sizes 20 µg
Species Reactivities Human

G α i-1 Double Nickase Plasmid (h) - sc-400652-NIC from Santa Cruz Biotechnology

Prices $345.00
Sizes 20 µg
Species Reactivities Human

G α i-1 Double Nickase Plasmid (h2) - sc-400652-NIC-2 from Santa Cruz Biotechnology

Prices $345.00
Sizes 20 µg
Species Reactivities Human

G α i-1 CRISPR Activation Plasmid (h) - sc-400652-ACT from Santa Cruz Biotechnology

Category CRISPR
Prices $345.00
Sizes 20 µg
Species Reactivities Human

G α i-1 CRISPR Activation Plasmid (h2) - sc-400652-ACT-2 from Santa Cruz Biotechnology

Category CRISPR
Prices $345.00
Sizes 20 µg
Species Reactivities Human

G α i-1 Lentiviral Activation Particles (h) - sc-400652-LAC from Santa Cruz Biotechnology

Prices $345.00
Sizes 20 µg
Species Reactivities Human

G α i-1 Lentiviral Activation Particles (h2) - sc-400652-LAC-2 from Santa Cruz Biotechnology

Prices $345.00
Sizes 20 µg
Species Reactivities Human

G α i-1 siRNA (h) - sc-105382 from Santa Cruz Biotechnology

Category siRNA
Prices $258.00
Sizes 10 µm
Species Reactivities Human

G α i-1 shRNA Plasmid (h) - sc-105382-SH from Santa Cruz Biotechnology

Category siRNA
Prices $258.00
Sizes 10 µm
Species Reactivities Human

G α i-1 shRNA (h) Lentiviral Particles - sc-105382-V from Santa Cruz Biotechnology

Category siRNA
Prices $258.00
Sizes 10 µm
Species Reactivities Human

G protein alpha inhibitor 1 RNAi - H00002770-R01 from Novus Biologicals

Category siRNA
Prices $399.00
Sizes 20 nmol
Species Reactivities Human

MISSION® esiRNA - EHU041091 from Sigma-Aldrich

Category siRNA
Prices $140.00, $250.00
Sizes 20 µg, 50 µg

CompoZr® Knockout ZFN Kit - CKOZFN9404 from Sigma-Aldrich

Category ZFN Kit
Prices $4,999.00
Sizes 1 kt

CompoZr® Knockout ZFN Kit, ZFN plasmid only - CKOZFND9404 from Sigma-Aldrich

Category ZFN Kit
Prices $3,999.00
Sizes 1 kt

MISSION® 3′UTR Lenti GoClone™ - HUTR10808 from Sigma-Aldrich

Category miRNA
Prices $350.00
Sizes hutr10808

GNAI1 siRNA (Human) - CRH1841 from Cohesion Biosciences

Category siRNA
Prices $340.00, $510.00
Sizes 15 nmol, 30 nmol
Species Reactivities Human

GNAI1 - MBS8239622 from MyBioSource

Prices $365.00, $515.00
Sizes 15 nmol, 30 nmol
Species Reactivities Human

Gα i-1 CRISPR/Cas9 KO Plasmid (h2) - sc-400652-KO-2 from Santa Cruz Biotechnology

Category CRISPR
Prices $345.00
Sizes 20 µg
Species Reactivities Human

Gα i-1 HDR Plasmid (h2) - sc-400652-HDR-2 from Santa Cruz Biotechnology

Prices $345.00
Sizes 20 µg
Species Reactivities Human

shRNA set against Human GNAI1 (NM_002069.5) - SHH304614 from Creative biogene

Category siRNA
Species Reactivities Human

shRNA set against Human GNAI1(NM_002069.5) - SHH091163 from Creative biogene

Category siRNA
Species Reactivities Human

Human GNAI1 siRNA - orb262343 from Biorbyt

Category siRNA
Prices $485.00, $629.00
Sizes 15 nmol, 30 nmol
Species Reactivities Human

GNAI1 shRNA Plasmid (Human) - CHH1841 from Cohesion Biosciences

Category siRNA
Prices $500.00, $750.00
Sizes 150 µg, 300 µg
Species Reactivities Human

GNAI1 miRNA 3'UTR clone - MiUTR1H-04100 from Creative biogene

Species Reactivities Human
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