| Gene Symbol |
UBLCP1
|
| Entrez Gene |
134510
|
| Alt Symbol |
CPUB1
|
| Species |
Human
|
| Gene Type |
protein-coding
|
| Description |
ubiquitin-like domain containing CTD phosphatase 1
|
| Other Description |
CTD phosphatase-like with ubiquitin domain 1|CTD-like phosphatase domain-containing protein|nuclear proteasome inhibitor UBLCP1|ubiquitin-like domain-containing CTD phosphatase 1
|
| Swissprots |
Q8WVY7 Q96DK5 D3DQJ7
|
| Accessions |
EAW61577 EAW61578 Q8WVY7 AK057996 BAB71628 AY444562 AAS68538 BC013425 AAH13425 BM676716 BM677370 DA930581 NM_145049 NP_659486
|
| Function |
Dephosphorylates 26S nuclear proteasomes, thereby decreasing their proteolytic activity. The dephosphorylation may prevent assembly of the core and regulatory particles (CP and RP) into mature 26S proteasome. {ECO:0000269|PubMed:21949367}.
|
| Subcellular Location |
Nucleus {ECO:0000269|PubMed:15883030, ECO:0000269|PubMed:21949367}. Note=Colocalizes with nuclear proteasomes.
|
| Tissue Specificity |
Broadly expressed, with highest levels in placenta, lung, testis and ovary. Up-regulated in tumor tissues. {ECO:0000269|PubMed:15883030}.
|