Gene Symbol | UBLCP1 |
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Entrez Gene | 134510 |
Alt Symbol | CPUB1 |
Species | Human |
Gene Type | protein-coding |
Description | ubiquitin-like domain containing CTD phosphatase 1 |
Other Description | CTD phosphatase-like with ubiquitin domain 1|CTD-like phosphatase domain-containing protein|nuclear proteasome inhibitor UBLCP1|ubiquitin-like domain-containing CTD phosphatase 1 |
Swissprots | Q8WVY7 Q96DK5 D3DQJ7 |
Accessions | EAW61577 EAW61578 Q8WVY7 AK057996 BAB71628 AY444562 AAS68538 BC013425 AAH13425 BM676716 BM677370 DA930581 NM_145049 NP_659486 |
Function | Dephosphorylates 26S nuclear proteasomes, thereby decreasing their proteolytic activity. The dephosphorylation may prevent assembly of the core and regulatory particles (CP and RP) into mature 26S proteasome. {ECO:0000269|PubMed:21949367}. |
Subcellular Location | Nucleus {ECO:0000269|PubMed:15883030, ECO:0000269|PubMed:21949367}. Note=Colocalizes with nuclear proteasomes. |
Tissue Specificity | Broadly expressed, with highest levels in placenta, lung, testis and ovary. Up-regulated in tumor tissues. {ECO:0000269|PubMed:15883030}. |
UBLCP1 CRISPR/Cas9 KO Plasmid (h) - sc-418179 from Santa Cruz Biotechnology
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UBLCP1 HDR Plasmid (h) - sc-418179-HDR from Santa Cruz Biotechnology
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UBLCP1 Double Nickase Plasmid (h) - sc-418179-NIC from Santa Cruz Biotechnology
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UBLCP1 Double Nickase Plasmid (h2) - sc-418179-NIC-2 from Santa Cruz Biotechnology
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UBLCP1 CRISPR Activation Plasmid (h) - sc-418179-ACT from Santa Cruz Biotechnology
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UBLCP1 CRISPR Activation Plasmid (h2) - sc-418179-ACT-2 from Santa Cruz Biotechnology
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UBLCP1 Lentiviral Activation Particles (h) - sc-418179-LAC from Santa Cruz Biotechnology
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UBLCP1 Lentiviral Activation Particles (h2) - sc-418179-LAC-2 from Santa Cruz Biotechnology
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UBLCP1 siRNA (h) - sc-91982 from Santa Cruz Biotechnology
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UBLCP1 shRNA Plasmid (h) - sc-91982-SH from Santa Cruz Biotechnology
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UBLCP1 shRNA (h) Lentiviral Particles - sc-91982-V from Santa Cruz Biotechnology
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MISSION® esiRNA - EHU036911 from Sigma-Aldrich
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MISSION® Human Phosphatase - SIHP0908 from Sigma-Aldrich
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MISSION® Human Phosphatase - SIHP0907 from Sigma-Aldrich
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MISSION® Human Phosphatase - SIHP0909 from Sigma-Aldrich
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CompoZr® Knockout ZFN Kit - CKOZFN22404 from Sigma-Aldrich
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CompoZr® Knockout ZFN Kit, ZFN plasmid only - CKOZFND22404 from Sigma-Aldrich
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MISSION® 3′UTR Lenti GoClone™ - HUTR08341 from Sigma-Aldrich
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UBLCP1 siRNA (Human) - CRJ5146 from Cohesion Biosciences
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UBLCP1 - MBS8241191 from MyBioSource
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shRNA set against Human UBLCP1 (NM_145049.3) - SHH439396 from Creative biogene
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Human UBLCP1 siRNA - orb275647 from Biorbyt
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UBLCP1 shRNA Plasmid (Human) - CHJ5146 from Cohesion Biosciences
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UBLCP1 miRNA 3'UTR clone - MiUTR3H-10861 from Creative biogene
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