| Gene Symbol |
SAP30
|
| Entrez Gene |
8819
|
| Alt Symbol |
-
|
| Species |
Human
|
| Gene Type |
protein-coding
|
| Description |
Sin3A-associated protein, 30kDa
|
| Other Description |
30 kDa Sin3-associated polypeptide|Sin3 corepressor complex subunit SAP30|Sin3-associated polypeptide, 30kDa|histone deacetylase complex subunit SAP30|sin3-associated polypeptide p30|sin3-associated polypeptide, 30 kDa
|
| Swissprots |
D3DP38 O75446
|
| Accessions |
EAX04755 EAX04756 O75446 AF055993 AAC33316 AW236579 BC016757 AAH16757 DQ892828 ABM83754 NM_003864 NP_003855
|
| Function |
Involved in the functional recruitment of the Sin3- histone deacetylase complex (HDAC) to a specific subset of N-CoR corepressor complexes. Capable of transcription repression by N- CoR. Active in deacetylating core histone octamers (when in a complex) but inactive in deacetylating nucleosomal histones. {ECO:0000250|UniProtKB:O88574, ECO:0000269|PubMed:9651585}.
|
| Subcellular Location |
Nucleus.
|
| Tissue Specificity |
Expressed in all tissues tested with highest levels in pancreas, ovary, PBL, spleen and thymus; lowest levels in brain, placenta, lung and kidney. {ECO:0000269|PubMed:9702189}.
|