| Gene Symbol |
NAF1
|
| Entrez Gene |
92345
|
| Alt Symbol |
-
|
| Species |
Human
|
| Gene Type |
protein-coding
|
| Description |
nuclear assembly factor 1 ribonucleoprotein
|
| Other Description |
H/ACA ribonucleoprotein complex non-core subunit NAF1|nuclear assembly factor 1 homolog
|
| Swissprots |
D3DP28 E9PAZ2 Q96HR8
|
| Accessions |
EAX04843 EAX04844 Q96HR8 AK097352 AK126037 AK308601 BC008207 AAH08207 XM_005263349 XP_005263406 XM_011532410 XP_011530712 XM_011532411 XP_011530713 XR_938794 XR_938795 XR_938796 XR_938797 XR_938798 XR_938799 NM_001128931 NP_001122403 NM_138386 NP_612395
|
| Function |
RNA-binding protein required for the maturation of box H/ACA snoRNPs complex and ribosome biogenesis. During assembly of the H/ACA snoRNPs complex, it associates with the complex and disappears during maturation of the complex and is replaced by NOLA1/GAR1 to yield mature H/ACA snoRNPs complex. Probably competes with NOLA1/GAR1 for binding with DKC1/NOLA4. {ECO:0000269|PubMed:16618814}.
|
| Subcellular Location |
Cytoplasm. Nucleus. Note=Shuttles between the cytoplasm and the nucleus. Absent from the nucleolus (By similarity). {ECO:0000250}.
|
![Western Blot: NAF1 Overexpression Lysate (Adult Normal) [NBP2-05666] Left-Empty vector transfected control cell lysate (HEK293 cell lysate); Right -Over-expression Lysate for NAF1.](http://www.bioprodhub.com/system/product_images/cel_products/5/sub_2/10543_NAF1%2520Overexpression%2520Lysate%2520(Adult%2520Normal)-Western%2520Blot-NBP2-05666-img0001.jpg)