Gene Symbol | NAF1 |
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Entrez Gene | 92345 |
Alt Symbol | - |
Species | Human |
Gene Type | protein-coding |
Description | nuclear assembly factor 1 ribonucleoprotein |
Other Description | H/ACA ribonucleoprotein complex non-core subunit NAF1|nuclear assembly factor 1 homolog |
Swissprots | D3DP28 E9PAZ2 Q96HR8 |
Accessions | EAX04843 EAX04844 Q96HR8 AK097352 AK126037 AK308601 BC008207 AAH08207 XM_005263349 XP_005263406 XM_011532410 XP_011530712 XM_011532411 XP_011530713 XR_938794 XR_938795 XR_938796 XR_938797 XR_938798 XR_938799 NM_001128931 NP_001122403 NM_138386 NP_612395 |
Function | RNA-binding protein required for the maturation of box H/ACA snoRNPs complex and ribosome biogenesis. During assembly of the H/ACA snoRNPs complex, it associates with the complex and disappears during maturation of the complex and is replaced by NOLA1/GAR1 to yield mature H/ACA snoRNPs complex. Probably competes with NOLA1/GAR1 for binding with DKC1/NOLA4. {ECO:0000269|PubMed:16618814}. |
Subcellular Location | Cytoplasm. Nucleus. Note=Shuttles between the cytoplasm and the nucleus. Absent from the nucleolus (By similarity). {ECO:0000250}. |
NAF1 CRISPR/Cas9 KO Plasmid (h) - sc-413941 from Santa Cruz Biotechnology
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NAF1 HDR Plasmid (h) - sc-413941-HDR from Santa Cruz Biotechnology
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NAF1 Double Nickase Plasmid (h) - sc-413941-NIC from Santa Cruz Biotechnology
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NAF1 Double Nickase Plasmid (h2) - sc-413941-NIC-2 from Santa Cruz Biotechnology
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NAF1 CRISPR Activation Plasmid (h) - sc-413941-ACT from Santa Cruz Biotechnology
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NAF1 CRISPR Activation Plasmid (h2) - sc-413941-ACT-2 from Santa Cruz Biotechnology
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NAF1 Lentiviral Activation Particles (h) - sc-413941-LAC from Santa Cruz Biotechnology
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NAF1 Lentiviral Activation Particles (h2) - sc-413941-LAC-2 from Santa Cruz Biotechnology
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NAF1 siRNA (h) - sc-89243 from Santa Cruz Biotechnology
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NAF1 shRNA Plasmid (h) - sc-89243-SH from Santa Cruz Biotechnology
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NAF1 shRNA (h) Lentiviral Particles - sc-89243-V from Santa Cruz Biotechnology
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MISSION® esiRNA - EHU130961 from Sigma-Aldrich
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CompoZr® Knockout ZFN Kit - CKOZFN14929 from Sigma-Aldrich
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CompoZr® Knockout ZFN Kit, ZFN plasmid only - CKOZFND14929 from Sigma-Aldrich
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MISSION® 3′UTR Lenti GoClone™ - HUTR01367 from Sigma-Aldrich
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NAF1 siRNA (Human) - CRJ4134 from Cohesion Biosciences
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shRNA set against Human NAF1 (NM_138386.2) - SHH349008 from Creative biogene
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Human NAF1 siRNA - orb274635 from Biorbyt
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NAF1 shRNA Plasmid (Human) - CHJ4134 from Cohesion Biosciences
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NAF1 miRNA 3'UTR clone - MiUTR3H-15330 from Creative biogene
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NAF1 miRNA 3'UTR clone - MiUTR3H-15331 from Creative biogene
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