GGPS1

Gene Symbol GGPS1
Entrez Gene 9453
Alt Symbol GGPPS, GGPPS1
Species Human
Gene Type protein-coding
Description geranylgeranyl diphosphate synthase 1
Other Description (2E,6E)-farnesyl diphosphate synthase|GGPP synthase|GGPPSase|dimethylallyltranstransferase|farnesyl diphosphate synthase|farnesyltranstransferase|geranylgeranyl pyrophosphate synthase|geranyltranstransferase
Swissprots Q6NW19 O95749 A8MVQ8 Q5T2C8
Accessions EAW70016 EAW70017 EAW70018 EAW70019 EAW70020 O95749 AB016043 BAA76511 AB017971 BAA75909 AB019036 BAA77251 AF057698 AAG45581 AF125394 AAD43050 AI088775 AK025139 AK293278 BAH11480 BC005252 AAH05252 BC067768 AAH67768 BI462253 BI520491 BI963107 CB216084 DB473584 HQ448140 ADQ32621 NM_001037277 NP_001032354 NR_036605 NM_001037278 NM_004837
Function Catalyzes the trans-addition of the three molecules of IPP onto DMAPP to form geranylgeranyl pyrophosphate, an important precursor of carotenoids and geranylated proteins.
Subcellular Location Cytoplasm.
Tissue Specificity Abundantly expressed in testis. Found in other tissues to a lower extent.
Top Pathways Terpenoid backbone biosynthesis

GGPS1 (B-2) - sc-271679 from Santa Cruz Biotechnology

Prices $279.00
Sizes 200 µg/ml
Host Mouse
Clonality Monoclonal
GGPS1 (B-2): sc-271679. Western blot analysis of GGPS1 expression in HeLa whole cell lysate.

GGPS1 (E-1) - sc-271680 from Santa Cruz Biotechnology

Prices $279.00
Sizes 200 µg/ml
Host Mouse
Clonality Monoclonal
GGPS1 (E-1): sc-271680. Western blot analysis of GGPS1 expression in HeLa whole cell lysate.

GGPS1 (E-14) - sc-161640 from Santa Cruz Biotechnology

Prices $279.00
Sizes 200 µg/ml
Host Goat
Clonality Polyclonal

GGPS1 (FL-300) - sc-134709 from Santa Cruz Biotechnology

Prices $279.00
Sizes 200 µg/ml
Host Rabbit
Clonality Polyclonal

Anti-GGPS1 antibody - ab56579 from Abcam

Prices $370.00
Sizes 100 µg
Host Mouse
Clonality Monoclonal
Overlay histogram showing HepG2 cells stained with ab56579 (red line). The cells were fixed with 80% methanol (5 min) and then permeabilized with 0.1% PBS-Tween for 20 min. The cells were then incubated in 1x PBS / 10% normal goat serum / 0.3M glycine to block non-specific protein-protein interactions followed by the antibody (ab56579, 0.1μg/1x106 cells) for 30 min at 22°C. The secondary antibody used was Alexa Fluor® 488 goat anti-mouse IgG (H+L) (ab150113) at 1/2000 dilution for 30 min at 22°C. Isotype control antibody (black line) was mouse IgG2b [PLPV219] (ab91366, 1μg/1x106 cells) used under the same conditions. Unlabelled sample (blue line) was also used as a control. Acquisition of >5,000 events were collected using a 20mW Argon ion laser (488nm) and 525/30 bandpass filter.

Anti-GGPS1 antibody - ab129924 from Abcam

Prices $370.00
Sizes 400 µl
Host Rabbit
Clonality Polyclonal
Anti-GGPS1 antibody (ab129924) at 1/100 dilution + 293 cell line lysates at 35 µg

Anti-GGPS1 antibody [2E7] - ab118058 from Abcam

Prices $370.00
Sizes 100 µl
Host Mouse
Clonality Monoclonal
Clone 2E7
All lanes : Anti-GGPS1 antibody [2E7] (ab118058) at 1/2000 dilutionLane 1 : HEK293T cell lysate transfected with pCMV6-ENTRY control Lane 2 : HEK293T cell lysate transfected with pCMV6-ENTRY GGPS1 cDNALysates/proteins at 5 µg per lane.

Anti-GGPS1 antibody [EPR9682] - ab167168 from Abcam

Prices $357.00
Sizes 100 µl
Host Rabbit
Clonality Monoclonal
Clone EPR9682
All lanes : Anti-GGPS1 antibody [EPR9682] (ab167168) at 1/1000 dilutionLane 1 : K562 cell lysates Lane 2 : HeLa cell lysates Lane 3 : 293T cell lysates Lane 4 : Jurkat cell lysates Lysates/proteins at 10 µg per lane.SecondaryGoat anti-rabbit HRP at 1/2000 dilution

Anti-GGPS1 antibody [EPR9683] - ab151696 from Abcam

Prices $357.00
Sizes 100 µl
Host Rabbit
Clonality Monoclonal
Clone EPR9683
All lanes : Anti-GGPS1 antibody [EPR9683] (ab151696) at 1/1000 dilutionLane 1 : K562 cell lysateLane 2 : 293T cell lysateLane 3 : Human testis lysateLysates/proteins at 10 µg per lane.SecondaryGoat anti-rabbit HRP at 1/2000 dilution

Anti-GGPS1 Antibody (C-Terminus) - LS-C81254 from LifeSpan Bioscience

Prices $365.00
Sizes 50 µg
Host Rabbit
Clonality Polyclonal
HepG2 cell lysate. Antibody concentration: 0.25 ug/ml. Gel concentration: 12%.

Anti-GGPS1 Antibody (aa180-229) - LS-C81253 from LifeSpan Bioscience

Prices $365.00
Sizes 50 µg
Host Rabbit
Clonality Polyclonal
293T cell lysate. Antibody concentration: 1.0 ug/ml. Gel concentration: 12%.

Anti-GGPS1 Antibody (aa174-202, APC) - LS-C257718 from LifeSpan Bioscience

Prices $545.00
Sizes 200 µl
Host Rabbit
Clonality Polyclonal

Anti-GGPS1 Antibody (aa201-301, clone 10C352, Azide-free) - LS-C183650 from LifeSpan Bioscience

Host Mouse
Clonality Monoclonal
Clone 10C352

Anti-GGPS1 Antibody (aa174-202, FITC) - LS-C257719 from LifeSpan Bioscience

Prices $545.00
Sizes 200 µl
Host Rabbit
Clonality Polyclonal

Anti-GGPS1 Antibody (clone 1C6) - LS-C115647 from LifeSpan Bioscience

Prices $325.00
Sizes 100 µl
Host Mouse
Clonality Monoclonal
Clone 1C6
HEK293T cells were transfected with the pCMV6-ENTRY control (Left lane) or pCMV6-ENTRY GGPS1 (Right lane) cDNA for 48 hrs and lysed. Equivalent amounts of cell lysates (5 ug per lane) were separated by SDS-PAGE and immunoblotted with anti-GGPS1.

Anti-GGPS1 Antibody (clone 2E7) - LS-C115646 from LifeSpan Bioscience

Prices $325.00
Sizes 100 µl
Host Mouse
Clonality Monoclonal
Clone 2E7
HEK293T cells were transfected with the pCMV6-ENTRY control (Left lane) or pCMV6-ENTRY GGPS1 (Right lane) cDNA for 48 hrs and lysed. Equivalent amounts of cell lysates (5 ug per lane) were separated by SDS-PAGE and immunoblotted with anti-GGPS1.

Anti-GGPS1 Antibody (aa174-202, Azide-free, HRP) - LS-C257721 from LifeSpan Bioscience

Prices $545.00
Sizes 200 µl
Host Rabbit
Clonality Polyclonal

Anti-GGPS1 Antibody (aa174-202, PE) - LS-C257722 from LifeSpan Bioscience

Prices $545.00
Sizes 200 µl
Host Rabbit
Clonality Polyclonal

Anti-GGPS1 Antibody (aa174-202, Biotin) - LS-C257727 from LifeSpan Bioscience

Prices $545.00
Sizes 200 µl
Host Rabbit
Clonality Polyclonal

Anti-GGPS1 Antibody (aa174-202, AP) - LS-C259955 from LifeSpan Bioscience

Prices $545.00
Sizes 200 µl
Host Rabbit
Clonality Polyclonal

Anti-GGPS1 Antibody (N-Terminus, AP) - LS-C277590 from LifeSpan Bioscience

Prices $515.00
Sizes 200 µl
Host Rabbit
Clonality Polyclonal

Anti-GGPS1 Antibody (aa270-300) - LS-C98447 from LifeSpan Bioscience

Prices $295.00
Sizes 400 µl
Host Rabbit
Clonality Polyclonal
Formalin-fixed and paraffin-embedded human breast carcinoma tissue reacted with GGPS1 Antibody , which was peroxidase-conjugated to the secondary antibody, followed by DAB staining. This data demonstrates the use of this antibody for immunohistochemistry; clinical relevance has not been evaluated.

Anti-GGPS1 Antibody (N-Terminus, APC) - LS-C277591 from LifeSpan Bioscience

Prices $515.00
Sizes 200 µl
Host Rabbit
Clonality Polyclonal

Anti-GGPS1 Antibody (aa174-202) - LS-C166459 from LifeSpan Bioscience

Prices $295.00
Sizes 400 µl
Host Rabbit
Clonality Polyclonal
GGPS1 Antibody western blot of 293 cell line lysates (35 ug/lane). The GGPS1 antibody detected the GGPS1 protein (arrow).

Anti-GGPS1 Antibody (N-Terminus, Biotin) - LS-C277592 from LifeSpan Bioscience

Prices $515.00
Sizes 200 µl
Host Rabbit
Clonality Polyclonal
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