Gene Symbol | VIPAS39 |
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Entrez Gene | 63894 |
Alt Symbol | C14orf133, SPE-39, SPE39, VIPAR, VPS16B, hSPE-39 |
Species | Human |
Gene Type | protein-coding |
Description | VPS33B interacting protein, apical-basolateral polarity regulator, spe-39 homolog |
Other Description | VPS33B-interacting protein in apical-basolateral polarity regulator|VPS33B-interacting protein in polarity and apical restriction|VPS33B-interacting protein involved in polarity and apical protein restriction|protein spe-39 homolog|spermatogenesis-defective protein 39 homolog |
Swissprots | Q9H9I9 Q9H9C1 O95434 B4DPI6 Q9H7E1 |
Accessions | AAD09624 EAW81286 EAW81287 EAW81288 EAW81289 EAW81290 Q9H9C1 AA010625 AK022769 BAB14237 AK022925 BAB14310 AK024661 BAB14951 AK098254 BAG53601 AK222706 BAD96426 AK297388 BAG59829 AK298354 BAG60598 AW629161 BC015054 AAH15054 CR457294 CAG33575 DA794284 XM_011537066 XP_011535368 NM_001193314 NP_001180243 NM_001193315 NP_001180244 NM_001193316 NP_001180245 NM_001193317 NP_001180246 NM_022067 NP_071350 |
Function | May play a role in vesicular trafficking during spermatogenesis (By similarity). Plays a role in lysosomal trafficking, probably via association with the core HOPS complex in a discrete population of endosomes. May play a role in epithelial polarization through stabilization of apical membrane protein content, possibly via the RAB11A-dependent apical recycling pathway. Also involved in direct or indirect transcriptional regulation of E-cadherin. {ECO:0000250, ECO:0000269|PubMed:19109425, ECO:0000269|PubMed:20190753}. |
Subcellular Location | Cytoplasm {ECO:0000250}. Cytoplasmic vesicle {ECO:0000250}. Early endosome. Recycling endosome. Late endosome. Note=Colocalizes in clusters with VPS33B at cytoplasmic organelles. {ECO:0000250}. |
VIPAR CRISPR/Cas9 KO Plasmid (h) - sc-416334 from Santa Cruz Biotechnology
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VIPAR HDR Plasmid (h) - sc-416334-HDR from Santa Cruz Biotechnology
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VIPAR Double Nickase Plasmid (h) - sc-416334-NIC from Santa Cruz Biotechnology
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VIPAR Double Nickase Plasmid (h2) - sc-416334-NIC-2 from Santa Cruz Biotechnology
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VIPAR CRISPR Activation Plasmid (h) - sc-416334-ACT from Santa Cruz Biotechnology
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VIPAR CRISPR Activation Plasmid (h2) - sc-416334-ACT-2 from Santa Cruz Biotechnology
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VIPAR Lentiviral Activation Particles (h) - sc-416334-LAC from Santa Cruz Biotechnology
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VIPAR Lentiviral Activation Particles (h2) - sc-416334-LAC-2 from Santa Cruz Biotechnology
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VIPAR siRNA (h) - sc-92099 from Santa Cruz Biotechnology
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VIPAR shRNA Plasmid (h) - sc-92099-SH from Santa Cruz Biotechnology
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VIPAR shRNA (h) Lentiviral Particles - sc-92099-V from Santa Cruz Biotechnology
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MISSION® esiRNA - EHU086091 from Sigma-Aldrich
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CompoZr® Knockout ZFN Kit - CKOZFN22685 from Sigma-Aldrich
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CompoZr® Knockout ZFN Kit, ZFN plasmid only - CKOZFND22685 from Sigma-Aldrich
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MISSION® 3′UTR Lenti GoClone™ - HUTR07265 from Sigma-Aldrich
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VIPAS39 siRNA (Human) - CRJ1847 from Cohesion Biosciences
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VIPAS39 - MBS8211474 from MyBioSource
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shRNA set against Human VIPAR (NM_022067.3) - SHH442780 from Creative biogene
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VIPAS39 shRNA Plasmid (Human) - CHJ1847 from Cohesion Biosciences
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VIPAS39 miRNA 3'UTR clone - MiUTR3H-12882 from Creative biogene
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