VMP1

Gene Symbol	VMP1
Entrez Gene	81671
Alt Symbol	EPG3, TANGO5, TMEM49
Species	Human
Gene Type	protein-coding
Description	vacuole membrane protein 1
Other Description	ectopic P-granules autophagy protein 3 homolog\|transmembrane protein 49\|transport and golgi organization 5 homolog
Swissprots	Q96GC9 Q9H0P4 Q9P089 B4DVV9
Accessions	CAC33315 EAW94390 EAW94391 EAW94392 EAW94393 Q96GC9 AB047551 BAF47368 AF161410 AAF28970 AF214006 AAL36461 AK024969 AK025987 AK293578 BAG57048 AK293664 BAG57110 AK294854 BAG57958 AK301254 BAG62821 AL136711 CAB66646 AM393551 CAL38428 AM393627 CAL38503 AX775965 CAE11682 BC009758 AAH09758 BC024020 CR533521 CAG38552 DC428792 DQ892569 ABM83495 NM_030938 NP_112200
Function	Stress-induced protein that, when overexpressed, promotes formation of intracellular vacuoles followed by cell death. May be involved in the cytoplasmic vacuolization of acinar cells during the early stage of acute pancreatitis. Plays a role in the initial stages of the autophagic process through its interaction with BECN1 (By similarity). Involved in cell-cell adhesion. Plays an essential role in formation of cell junctions. {ECO:0000250, ECO:0000269\|PubMed:17724469}.
Subcellular Location	Endoplasmic reticulum-Golgi intermediate compartment membrane {ECO:0000250}; Multi-pass membrane protein {ECO:0000250}. Cell membrane {ECO:0000269\|PubMed:17724469}; Multi- pass membrane protein {ECO:0000269\|PubMed:17724469}. Vacuole membrane {ECO:0000250}; Multi-pass membrane protein {ECO:0000250}. Endoplasmic reticulum {ECO:0000269\|PubMed:17724469}.

TMEM49/VMP1 (D6N4G) Rabbit mAb - 12978 from Cell Signaling Technology

Prices	$246.00
Sizes	100 µl (10 western blots)
Host	Rabbit
Clonality	Monoclonal
Clone	D6N4G

Western blot analysis of extracts from various cell lines using TMEM49/VMP1 (D6N4G) Rabbit mAb.

TMEM49/VMP1 (D1Y3E) Rabbit mAb - 12929 from Cell Signaling Technology

Prices	$246.00
Sizes	100 µl (10 western blots)
Host	Rabbit
Clonality	Monoclonal
Clone	D1Y3E

Western blot analysis of extracts from various cell lines using TMEM49/VMP1 (D1Y3E) Rabbit mAb.

TMEM49/VMP1 Antibody - 4643 from Cell Signaling Technology

Host	Rabbit
Clonality	Polyclonal

VMP1 (A-13) - sc-160869 from Santa Cruz Biotechnology

Prices	$279.00
Sizes	200 µg/ml
Host	Goat
Clonality	Polyclonal

Anti-TMEM49 antibody - ab69224 from Abcam

Prices	$370.00
Sizes	50 µg
Host	Mouse
Clonality	Polyclonal

All lanes : Anti-TMEM49 antibody (ab69224) at 1/500 dilutionLane 1 : TMEM49 transfected 293T lysateLane 2 : Non-transfected 293T lysateLysates/proteins at 25 µg per lane.SecondaryGoat Anti-Mouse IgG (H&L)-HRP at 1/2500 dilution

Anti-TMEM49 antibody - ab116006 from Abcam

Prices	$359.00
Sizes	100 µg
Host	Rabbit
Clonality	Polyclonal

Anti-TMEM49 antibody (ab116006) at 1/100 dilution + HepG2 cell line lysate at 35 µg

Anti-TMEM49 antibody - C-terminal - ab203684 from Abcam

Prices	$359.00
Sizes	100 µl
Host	Rabbit
Clonality	Polyclonal

Immunohistochemical analysis of formalin-fixed, paraffin-embedded Human lung carcinoma tissue labeling TMEM49 with ab203684 at 1/200 dilution, followed by conjugation to the secondary antibody and DAB staining.

Anti-TMEM49 antibody - C-terminal - ab181674 from Abcam

Host	Rabbit
Clonality	Polyclonal

Anti-TMEM49 Antibody (C-Terminus) - LS-C144863 from LifeSpan Bioscience

Prices	$275.00
Sizes	100 µl
Host	Rabbit
Clonality	Polyclonal

Anti-TMEM49 Antibody (aa377-406, AP) - LS-C207784 from LifeSpan Bioscience

Prices	$545.00
Sizes	200 µl
Host	Rabbit
Clonality	Polyclonal

Anti-TMEM49 Antibody (aa377-406, APC) - LS-C207785 from LifeSpan Bioscience

Prices	$545.00
Sizes	200 µl
Host	Rabbit
Clonality	Polyclonal

Anti-TMEM49 Antibody (aa377-406, Biotin) - LS-C207786 from LifeSpan Bioscience

Prices	$545.00
Sizes	200 µl
Host	Rabbit
Clonality	Polyclonal

Anti-TMEM49 Antibody (aa377-406, FITC) - LS-C207787 from LifeSpan Bioscience

Prices	$545.00
Sizes	200 µl
Host	Rabbit
Clonality	Polyclonal

Anti-TMEM49 Antibody (aa377-406, Azide-free, HRP) - LS-C207788 from LifeSpan Bioscience

Prices	$545.00
Sizes	200 µl
Host	Rabbit
Clonality	Polyclonal

Anti-TMEM49 Antibody (aa377-406, PE) - LS-C207789 from LifeSpan Bioscience

Prices	$545.00
Sizes	200 µl
Host	Rabbit
Clonality	Polyclonal

Anti-TMEM49 Antibody (aa376-406) - LS-C325799 from LifeSpan Bioscience

Prices	$435.00
Sizes	200 µl
Host	Rabbit
Clonality	Polyclonal

Anti-TMEM49 Antibody (Internal) - LS-C345477 from LifeSpan Bioscience

Prices	$365.00
Sizes	50 µg
Host	Rabbit
Clonality	Polyclonal

Western blot of VMP1 Antibody with human HepG2 Whole Cell lysate.

Anti-TMEM49 Antibody (aa377-406) - LS-C162013 from LifeSpan Bioscience

Prices	$295.00
Sizes	400 µl
Host	Rabbit
Clonality	Polyclonal

TMEM49 Antibody western blot of HepG2 cell line lysates (35 ug/lane). The TMEM49 antibody detected the TMEM49 protein (arrow).

TMEM49 Antibody - NBP1-83971 from Novus Biologicals

Prices	$419.00
Sizes	100 µl
Host	Rabbit
Clonality	Polyclonal

Immunohistochemistry-Paraffin: TMEM49 Antibody [NBP1-83971] - Staining of human testis shows strong cytoplasmic positivity in cells in seminiferus ducts.

TMEM49 Antibody - NBP1-19041 from Novus Biologicals

Prices	$299.00
Sizes	200 µl
Host	Rabbit
Clonality	Polyclonal

TMEM49 Antibody - H00081671-B01P from Novus Biologicals

Prices	$359.00
Sizes	50 µg
Host	Mouse
Clonality	Polyclonal

Western Blot: TMEM49 Antibody [H00081671-B01P] - Analysis of TMEM49 expression in C32.

TMEM49 Polyclonal Antibody - bs-6740R from Bioss

Prices	$269.00
Sizes	100 µl
Host	Rabbit
Clonality	Polyclonal

$Formalin-fixed and paraffin embedded human lung carcinoma labeled with Anti-TMEM49 Polyclonal Antibody, Unconjugated (bs-6740R) at 1:200 followed by conjugation to the secondary antibody and DAB staining\\n$

ANTI-TMEM49 (C-TERM) antibody produced in rabbit - SAB1304364 from Sigma-Aldrich

Prices	$326.50
Sizes	100 µg
Host	Rabbit
Clonality	Polyclonal

<B>Immunoblotting</B><BR/>Anti-TMEM49 (C-term): <B>Cat. No. SAB1304364</B>: TMEM49 Antibody (C-term) western blot analysis in HepG2 cell line lysates (35 μg/lane).

Anti-VMP1 antibody produced in rabbit - HPA030773 from Sigma-Aldrich

Prices	$429.00
Sizes	100 µl
Host	Rabbit
Clonality	Polyclonal

<B>Immunohistochemistry</B><BR/>Anti-TMEM49: <B>Cat. No. HPA030773</B>: Immunohistochemical staining of human testis shows strong cytoplasmic positivity in cells in seminiferus ducts.

Anti-TMEM49 antibody produced in mouse - SAB1409853 from Sigma-Aldrich

Prices	$347.00
Sizes	50 µg
Host	Mouse
Clonality	Polyclonal

<B>Immunoblotting</B><BR/>Anti-TMEM49: <B>Cat. No. SAB1409853</B>: Antibody concentration: 0.1-5 μg/mL. Specific band of ~44.7 kDa using TMEM49 transfected 293T lysate.<BR/><B>Lanes</B><BR/>1. Transfected 293T lysate.<BR/>2. Non-transfected 293T lysate.

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