ANK1
| Gene Symbol | ANK1 |
|---|---|
| Entrez Gene | 286 |
| Alt Symbol | ANK, SPH1, SPH2 |
| Species | Human |
| Gene Type | protein-coding |
| Description | ankyrin 1, erythrocytic |
| Other Description | ANK-1|ankyrin-1|ankyrin-R|erythrocyte ankyrin |
| Swissprots | E5RFL7 Q8N604 O43400 P16157 Q13768 Q59FP2 Q53ER1 A0PJN8 A6NJ23 Q99407 |
| Accessions | AAB46776 AAB47804 AAB47805 EAW63241 EAW63242 EAW63243 EAW63244 EAW63245 EAW63246 EAW63247 EAW63248 EAW63249 EAW63250 P16157 AA404587 AB209418 BAD92655 AI167814 AI684839 AK126647 BAG54351 AK129864 AK223578 BAD97298 BC007930 AAH07930 BC014467 BC030957 AAH30957 BC117121 AAI17122 BC156401 AAI56402 BX647936 F28948 HQ447752 ADQ32237 M28880 AAA51732 N63745 X16609 CAA34610 XM_005273476 XP_005273533 XM_011544490 XP_011542792 XM_011544491 XP_011542793 XM_011544492 XP_011542794 XM_011544493 XP_011542795 XM_011544494 XP_011542796 XM_011544495 XP_011542797 XM_011544496 XP_011542798 XM_011544497 XP_011542799 XM_011544498 XP_011542800 XM_011544499 XP_011542801 XM_011544500 XP_011542802 XM_011544501 XP_011542803 XM_011544502 XP_011542804 XM_011544503 XP_011542805 XM_011544504 XP_011542806 XM_011544505 XP_011542807 XM_011544506 XP_011542808 XR_949389 NM_000037 NP_000028 NM_001142445 NP_001135917 NM_001142446 NP_001135918 NM_020475 NP_065208 NM_020476 NP_065209 NM_020477 NP_065210 NM_020478 NP_065211 NM_020480 NP_065213 NM_020479 NM_020481 |
| Function | Attaches integral membrane proteins to cytoskeletal elements; binds to the erythrocyte membrane protein band 4.2, to Na-K ATPase, to the lymphocyte membrane protein GP85, and to the cytoskeletal proteins fodrin, tubulin, vimentin and desmin. Erythrocyte ankyrins also link spectrin (beta chain) to the cytoplasmic domain of the erythrocytes anion exchange protein; they retain most or all of these binding functions. {ECO:0000269|PubMed:12456646}. |
| Subcellular Location | Isoform Mu20: Sarcoplasmic reticulum {ECO:0000305}. |
| Tissue Specificity | Isoform Mu17, isoform Mu18, isoform Mu19 and isoform Mu20 are expressed in skeletal muscle. Isoform Br21 is expressed in brain. {ECO:0000269|PubMed:9430667}. |
| Top Pathways | Proteoglycans in cancer |
Ankyrin-1 CRISPR/Cas9 KO Plasmid (h) - sc-402403 from Santa Cruz Biotechnology
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Ankyrin-1 HDR Plasmid (h) - sc-402403-HDR from Santa Cruz Biotechnology
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Ankyrin-1 Double Nickase Plasmid (h) - sc-402403-NIC from Santa Cruz Biotechnology
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Ankyrin-1 Double Nickase Plasmid (h2) - sc-402403-NIC-2 from Santa Cruz Biotechnology
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Ankyrin-1 CRISPR Activation Plasmid (h) - sc-402403-ACT from Santa Cruz Biotechnology
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Ankyrin-1 CRISPR Activation Plasmid (h2) - sc-402403-ACT-2 from Santa Cruz Biotechnology
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Ankyrin-1 Lentiviral Activation Particles (h) - sc-402403-LAC from Santa Cruz Biotechnology
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Ankyrin-1 Lentiviral Activation Particles (h2) - sc-402403-LAC-2 from Santa Cruz Biotechnology
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Ankyrin-1 siRNA (h) - sc-43615 from Santa Cruz Biotechnology
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Ankyrin-1 shRNA Plasmid (h) - sc-43615-SH from Santa Cruz Biotechnology
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Ankyrin-1 shRNA (h) Lentiviral Particles - sc-43615-V from Santa Cruz Biotechnology
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Ankyrin 1 RNAi - H00000286-R03 from Novus Biologicals
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Ankyrin 1 RNAi - H00000286-R04 from Novus Biologicals
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Ankyrin 1 RNAi - H00000286-R01 from Novus Biologicals
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Ankyrin 1 RNAi - H00000286-R02 from Novus Biologicals
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Ankyrin 1 RNAi - H00000286-R05 from Novus Biologicals
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Ankyrin 1 RNAi - H00000286-R06 from Novus Biologicals
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MISSION® esiRNA - EHU099451 from Sigma-Aldrich
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CompoZr® Knockout ZFN Kit - CKOZFN3155 from Sigma-Aldrich
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CompoZr® Knockout ZFN Kit, ZFN plasmid only - CKOZFND3155 from Sigma-Aldrich
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ANK1 siRNA (Human) - CRH0199 from Cohesion Biosciences
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ANK1 - MBS8200147 from MyBioSource
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shRNA set against Human ANK1 (NM_000037.3) - SHH236342 from Creative biogene
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shRNA set against Human ANK1(NM_020475.2) - SHG058339 from Creative biogene
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shRNA set against Human ANK1(NM_020476.2) - SHG058375 from Creative biogene
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