Gene Symbol | DUSP18 |
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Entrez Gene | 150290 |
Alt Symbol | DSP18, DUSP20, LMWDSP20 |
Species | Human |
Gene Type | protein-coding |
Description | dual specificity phosphatase 18 |
Other Description | dual specificity protein phosphatase 18|low molecular weight dual specificity phosphatase 20 |
Swissprots | B3KPA4 Q8NEJ0 |
Accessions | EAW59913 EAW59914 EAW59915 Q8NEJ0 AF461689 AAN77931 AF533017 AAN59787 AI699242 AK025036 AK056074 BAG51616 BC004110 BC028724 BC030987 AAH30987 BM550612 CR456406 CAG30292 CU012964 CAK54395 CU013252 CAK54694 DA378760 XM_005261368 XP_005261425 XM_006724148 XP_006724211 XM_011529920 XP_011528222 XM_011529921 XP_011528223 NM_001304794 NP_001291723 NM_001304795 NP_001291724 NM_001304796 NP_001291725 NM_152511 NP_689724 |
Function | Can dephosphorylate single and diphosphorylated synthetic MAPK peptides, with preference for the phosphotyrosine and diphosphorylated forms over phosphothreonine. In vitro, dephosphorylates p-nitrophenyl phosphate (pNPP). |
Subcellular Location | Cytoplasm {ECO:0000269|PubMed:12408986}. Nucleus {ECO:0000269|PubMed:12408986}. |
Tissue Specificity | Widely expressed with highest levels in liver, brain, ovary and testis. {ECO:0000269|PubMed:12408986, ECO:0000269|PubMed:12591617}. |
DUSP18 CRISPR/Cas9 KO Plasmid (h) - sc-405897 from Santa Cruz Biotechnology
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DUSP18 HDR Plasmid (h) - sc-405897-HDR from Santa Cruz Biotechnology
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DUSP18 Double Nickase Plasmid (h) - sc-405897-NIC from Santa Cruz Biotechnology
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DUSP18 Double Nickase Plasmid (h2) - sc-405897-NIC-2 from Santa Cruz Biotechnology
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DUSP18 CRISPR Activation Plasmid (h) - sc-405897-ACT from Santa Cruz Biotechnology
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DUSP18 CRISPR Activation Plasmid (h2) - sc-405897-ACT-2 from Santa Cruz Biotechnology
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DUSP18 Lentiviral Activation Particles (h) - sc-405897-LAC from Santa Cruz Biotechnology
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DUSP18 Lentiviral Activation Particles (h2) - sc-405897-LAC-2 from Santa Cruz Biotechnology
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DUSP18 siRNA (h) - sc-77198 from Santa Cruz Biotechnology
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DUSP18 shRNA Plasmid (h) - sc-77198-SH from Santa Cruz Biotechnology
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DUSP18 shRNA (h) Lentiviral Particles - sc-77198-V from Santa Cruz Biotechnology
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MISSION® esiRNA - EHU115121 from Sigma-Aldrich
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MISSION® Human Phosphatase - SIHP0114 from Sigma-Aldrich
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MISSION® Human Phosphatase - SIHP0113 from Sigma-Aldrich
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MISSION® Human Phosphatase - SIHP0112 from Sigma-Aldrich
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CompoZr® Knockout ZFN Kit - CKOZFN7549 from Sigma-Aldrich
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CompoZr® Knockout ZFN Kit, ZFN plasmid only - CKOZFND7549 from Sigma-Aldrich
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MISSION® 3′UTR Lenti GoClone™ - HUTR09467 from Sigma-Aldrich
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DUSP18 siRNA (Human) - CRJ5650 from Cohesion Biosciences
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DUSP18 RNAi - H00150290-R01 from Novus Biologicals
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DUSP18 - MBS8212964 from MyBioSource
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DUSP18 CRISPR/Cas9 KO Plasmid (h2) - sc-405897-KO-2 from Santa Cruz Biotechnology
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DUSP18 HDR Plasmid (h2) - sc-405897-HDR-2 from Santa Cruz Biotechnology
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shRNA set against Human DUSP18 (NM_152511.3) - SHH281757 from Creative biogene
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shRNA set against Human DUSP18(NM_152511.3) - SHH018927 from Creative biogene
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