| Gene Symbol |
PDLIM5
|
| Entrez Gene |
10611
|
| Alt Symbol |
ENH, ENH1, L9, LIM
|
| Species |
Human
|
| Gene Type |
protein-coding
|
| Description |
PDZ and LIM domain 5
|
| Other Description |
PDZ and LIM domain protein 5|enigma homolog|enigma-like LIM domain protein|enigma-like PDZ and LIM domains protein
|
| Swissprots |
Q8WVK0 Q5UW38 Q56VN4 D6RB78 Q96HC4 O60705 A8K6F9 E9PBF5
|
| Accessions |
AAY40898 EAX06053 EAX06054 EAX06055 EAX06056 EAX06057 EAX06058 EAX06059 Q96HC4 AA253314 AA614664 AA888262 AA922628 AB209531 BAD92768 AF061258 AAC15767 AF116705 AAF71125 AI201986 AK027217 AK129886 AK291624 BAF84313 AK291898 BAF84587 AK296980 BAH12467 AK304125 BAH14111 AL049969 AL832157 AL832686 AL833151 AL833438 AL833439 AM393306 CAL38184 AM393394 CAL38272 AM393485 CAL38362 AM393621 CAL38497 AM393813 CAL38688 AY345240 AAR09142 AY598328 AAT06739 BC008741 AAH08741 BC017902 AAH17902 BC026029 BF954250 BF979604 BM670741 BP260089 BQ049008 BT007328 AAP35992 D31139 DA381128 DA895978 DQ890686 ABM81612 DQ893868 ABM84794 XM_005262693 XP_005262750 XM_005262695 XP_005262752 XM_005262696 XP_005262753 XM_005262698 XP_005262755 XM_006714066 XP_006714129 XM_006714067 XP_006714130 XM_006714068 XP_006714131 XM_006714069 XP_006714132 XM_006714070 XP_006714133 XM_011531543 XP_011529845 NM_001011513 NP_001011513 NM_001011515 NP_001011515 NM_001011516 NP_001011516 NM_001256425 NP_001243354 NM_001256426 NP_001243355 NM_001256427 NP_001243356 NM_001256428 NP_001243357 NM_001256429 NP_001243358 NM_006457 NP_006448 NR_046186
|
| Function |
May play an important role in the heart development by scaffolding PKC to the Z-disk region. May play a role in the regulation of cardiomyocyte expansion. Overexpression promotes the development of heart hypertrophy. Contributes to the regulation of dendritic spine morphogenesis in neurons. May restrain postsynaptic growth of excitatory synapses (By similarity). {ECO:0000250}.
|
| Subcellular Location |
Cell junction, synapse, postsynaptic cell membrane, postsynaptic density {ECO:0000250}. Cell junction, synapse, synaptosome {ECO:0000250}. Cytoplasm {ECO:0000250}. Note=Detected both at presynaptic and postsynaptic sites. {ECO:0000250}.
|
| Tissue Specificity |
Heart and skeletal muscle specific. Expression is commonly increased in the brain of patients with bipolar disorder, schizophrenia, and major depression. {ECO:0000269|PubMed:10429367, ECO:0000269|PubMed:16044170, ECO:0000269|PubMed:16213469}.
|