Gene Symbol | Lias |
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Entrez Gene | 305348 |
Alt Symbol | - |
Species | Rat |
Gene Type | protein-coding |
Description | lipoic acid synthetase |
Other Description | LS {ECO:0000255|HAMAP-Rule:MF_03123}|lip-syn {ECO:0000255|HAMAP-Rule:MF_03123}|lipoate synthase {ECO:0000255|HAMAP-Rule:MF_03123}|lipoic acid synthase {ECO:0000255|HAMAP-Rule:MF_03123}|lipoyl synthase, mitochondrial|lipoyl synthase, mitochondrial {ECO:0000255|HAMAP-Rule:MF_03123} |
Swissprots | Q5XIH4 |
Accessions | CBN72402 Q5XIH4 BC083708 AAH83708 XM_008770155 XP_008768377 XM_008770156 XP_008768378 NM_001012037 NP_001012037 |
Function | Catalyzes the radical-mediated insertion of two sulfur atoms into the C-6 and C-8 positions of the octanoyl moiety bound to the lipoyl domains of lipoate-dependent enzymes, thereby converting the octanoylated domains into lipoylated derivatives. {ECO:0000255|HAMAP-Rule:MF_03123}. |
Subcellular Location | Mitochondrion {ECO:0000255|HAMAP- Rule:MF_03123}. |
Top Pathways | Lipoic acid metabolism |
CompoZr® Knockout ZFN Kit - CKOZFN56149 from Sigma-Aldrich
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CompoZr® Knockout ZFN Kit, ZFN plasmid only - CKOZFND56149 from Sigma-Aldrich
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LIAS siRNA (Rat) - CRR4988 from Cohesion Biosciences
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shRNA set against Rat LIAS (NM_001012037.1) - SHH330199 from Creative biogene
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shRNA set against Rat Lias(NM_001012037.1) - SHH148965 from Creative biogene
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Rat LIAS siRNA - orb299837 from Biorbyt
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LIAS shRNA Plasmid (Rat) - CHR4988 from Cohesion Biosciences
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LIAS miRNA 3'UTR clone - MiUTR1R-03014 from Creative biogene
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