| Gene Symbol |
MPDZ
|
| Entrez Gene |
8777
|
| Alt Symbol |
HYC2, MUPP1
|
| Species |
Human
|
| Gene Type |
protein-coding
|
| Description |
multiple PDZ domain protein
|
| Other Description |
multi-PDZ domain protein 1
|
| Swissprots |
Q5JUC4 O75970 Q5VZ62 Q5CZ80 B2RTS3 B7ZMI4 O43798 Q8N790 Q5JUC3 Q5JTX7 A6NLC2 Q4LE30 Q5JTX6 Q5JTX3
|
| Accessions |
EAW58704 EAW58705 EAW58706 O75970 AB210041 BAE06123 AF093419 AAC61870 AJ001319 CAA04680 AK058011 AK074721 BAG51991 AK091945 BAG52447 AK098775 BAC05409 AK294823 BAG57936 AK294976 BAG58047 AK307924 AK307988 AK316489 BAH14860 BC140793 AAI40794 BC144564 AAI44565 BC172387 AAI72387 BU621500 CR936648 CAI56786 CX782625 HG501896 XM_005251622 XP_005251679 XM_005251623 XP_005251680 XM_006716885 XP_006716948 XM_006716886 XP_006716949 XM_006716887 XP_006716950 XM_006716888 XP_006716951 XM_006716889 XP_006716952 XM_006716890 XP_006716953 XM_006716891 XP_006716954 NM_001261406 NP_001248335 NM_001261407 NP_001248336 NM_003829 NP_003820
|
| Function |
Interacts with HTR2C and provokes its clustering at the cell surface (By similarity). Member of the NMDAR signaling complex that may play a role in control of AMPAR potentiation and synaptic plasticity in excitatory synapses. {ECO:0000250, ECO:0000269|PubMed:11150294, ECO:0000269|PubMed:15312654}.
|
| Subcellular Location |
Cell membrane; Peripheral membrane protein; Cytoplasmic side. Apical cell membrane; Peripheral membrane protein; Cytoplasmic side. Cell junction, synapse, postsynaptic cell membrane, postsynaptic density. Cell projection, dendrite. Cell junction, tight junction. Cell junction, synapse. Cell junction, synapse, synaptosome. Note=Associated with membranes. Colocalizes with HTR2C on the apical membrane of epithelial choroid plexus cells. Highly enriched in postsynaptic densities (PSD). Localized to punctae on dendrites of hippocampal neurons and colocalizes with the synaptic marker DLG4. Localized mainly in the Schmidt-Lanterman incisures of myelinating Schwann cells (By similarity). In the retina, localizes to the sub-apical region adjacent to the adherens junction complex at the outer limiting membrane. Enriched at the tight junctions of epithelial cells. Association to the tight junctions depends on CXADR. {ECO:0000250}.
|
| Tissue Specificity |
Expressed in heart, brain, placenta, liver, skeletal muscle, kidney and pancreas. {ECO:0000269|PubMed:9537516}.
|
| Top Pathways |
Tight junction
|