MPDZ

Gene Symbol	MPDZ
Entrez Gene	8777
Alt Symbol	HYC2, MUPP1
Species	Human
Gene Type	protein-coding
Description	multiple PDZ domain protein
Other Description	multi-PDZ domain protein 1
Swissprots	Q5JUC4 O75970 Q5VZ62 Q5CZ80 B2RTS3 B7ZMI4 O43798 Q8N790 Q5JUC3 Q5JTX7 A6NLC2 Q4LE30 Q5JTX6 Q5JTX3
Accessions	EAW58704 EAW58705 EAW58706 O75970 AB210041 BAE06123 AF093419 AAC61870 AJ001319 CAA04680 AK058011 AK074721 BAG51991 AK091945 BAG52447 AK098775 BAC05409 AK294823 BAG57936 AK294976 BAG58047 AK307924 AK307988 AK316489 BAH14860 BC140793 AAI40794 BC144564 AAI44565 BC172387 AAI72387 BU621500 CR936648 CAI56786 CX782625 HG501896 XM_005251622 XP_005251679 XM_005251623 XP_005251680 XM_006716885 XP_006716948 XM_006716886 XP_006716949 XM_006716887 XP_006716950 XM_006716888 XP_006716951 XM_006716889 XP_006716952 XM_006716890 XP_006716953 XM_006716891 XP_006716954 NM_001261406 NP_001248335 NM_001261407 NP_001248336 NM_003829 NP_003820
Function	Interacts with HTR2C and provokes its clustering at the cell surface (By similarity). Member of the NMDAR signaling complex that may play a role in control of AMPAR potentiation and synaptic plasticity in excitatory synapses. {ECO:0000250, ECO:0000269|PubMed:11150294, ECO:0000269|PubMed:15312654}.
Subcellular Location	Cell membrane; Peripheral membrane protein; Cytoplasmic side. Apical cell membrane; Peripheral membrane protein; Cytoplasmic side. Cell junction, synapse, postsynaptic cell membrane, postsynaptic density. Cell projection, dendrite. Cell junction, tight junction. Cell junction, synapse. Cell junction, synapse, synaptosome. Note=Associated with membranes. Colocalizes with HTR2C on the apical membrane of epithelial choroid plexus cells. Highly enriched in postsynaptic densities (PSD). Localized to punctae on dendrites of hippocampal neurons and colocalizes with the synaptic marker DLG4. Localized mainly in the Schmidt-Lanterman incisures of myelinating Schwann cells (By similarity). In the retina, localizes to the sub-apical region adjacent to the adherens junction complex at the outer limiting membrane. Enriched at the tight junctions of epithelial cells. Association to the tight junctions depends on CXADR. {ECO:0000250}.
Tissue Specificity	Expressed in heart, brain, placenta, liver, skeletal muscle, kidney and pancreas. {ECO:0000269|PubMed:9537516}.
Top Pathways	Tight junction

• Antibodies
• Assays/Kits
• Proteins/Peptides
• siRNAs/Functional Genomics
• Cell/Tissue/Blood Products

MPDZ / MUPP1 Antibody Blocking Peptide - LS-E15784 from LifeSpan Bioscience Category Peptide Prices $145.00 Sizes 100 µg

LNX1 blocking peptide - GTX88849-PEP from GeneTex Category Peptide Prices $239.00 Sizes 100 μg Species Human

MPDZ Blocking Peptide - 33R-1891 from Fitzgerald Category Peptide Prices $130.00 Sizes 100 µg

MPDZ fusion protein - ag18222 from Proteintech Group Category Protein Source E. coli-derived, PGEX-4T Species Human

Recombinant Human MPDZ - MPDZ-661H from Creative Biomart Category Protein Source Mammalian Cells Species Human

Recombinant Human Multiple PDZ domain protein(MPDZ) ,partial - CSB-YP014745HU CSB-EP014745HU CSB-BP014745HU CSB-MP014745HU from Cusabio Category Protein Source Yeast or E.coli or Baculovirus or Mammalian cell Species Human

MUPP1 Recombinant Protein Antigen - NBP1-87840PEP from Novus Biologicals Category Protein Prices $199.00 Sizes 100 µl Source E.coli Species Human

MUPP1 Recombinant Protein Antigen - NBP1-87839PEP from Novus Biologicals Category Protein Prices $199.00 Sizes 100 µl Source E.coli Species Human

MPDZ Peptide, Human - M34GP09667H from Creative Peptides Category Peptide Source Synthetic. Species Human

Multiple PDZ domain protein (MPDZ), partial, Recombinant Protein - MBS1103405 from MyBioSource Category Protein Source E Coli or Yeast or Baculovirus or Mammalian Cell Species Human

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