| Gene Symbol |
USP33
|
| Entrez Gene |
23032
|
| Alt Symbol |
VDU1
|
| Species |
Human
|
| Gene Type |
protein-coding
|
| Description |
ubiquitin specific peptidase 33
|
| Other Description |
VHL-interacting deubiquitinating enzyme 1|deubiquitinating enzyme 33|pVHL-interacting deubiquitinating enzyme 1|ubiquitin carboxyl-terminal hydrolase 33|ubiquitin thioesterase 33|ubiquitin thiolesterase 33|ubiquitin-specific-processing protease 33
|
| Swissprots |
Q9H9F0 Q9UPQ5 Q96AV6 Q8TEY7 Q8TEY6
|
| Accessions |
EAX06367 EAX06368 EAX06369 EAX06370 EAX06371 Q8TEY7 AB029020 BAA83049 AF383172 AAL78314 AF383173 AAL78315 AI569971 AK022864 BAB14279 AK023664 AK094056 AK225499 AK308402 AL050140 CAB43288 BC016663 AAH16663 BU631866 DB232523 DQ891487 ABM82413 DQ894672 ABM85598 XM_005270648 XP_005270705 XM_005270649 XP_005270706 XM_011541055 XP_011539357 XM_011541056 XP_011539358 XR_946588 XR_946589 NM_015017 NP_055832 NM_201624 NP_963918 NM_201626 NP_963920
|
| Function |
Deubiquitinating enzyme involved in various processes such as centrosome duplication, cellular migration and beta-2 adrenergic receptor/ADRB2 recycling. Involved in regulation of centrosome duplication by mediating deubiquitination of CCP110 in S and G2/M phase, leading to stabilize CCP110 during the period which centrioles duplicate and elongate. Involved in cell migration via its interaction with intracellular domain of ROBO1, leading to regulate the Slit signaling. Plays a role in commissural axon guidance cross the ventral midline of the neural tube in a Slit-dependent manner, possibly by mediating the deubiquitination of ROBO1. Acts as a regulator of G-protein coupled receptor (GPCR) signaling by mediating the deubiquitination of beta-arrestins (ARRB1 and ARRB2) and beta-2 adrenergic receptor (ADRB2). Plays a central role in ADRB2 recycling and resensitization after prolonged agonist stimulation by constitutively binding ADRB2, mediating deubiquitination of ADRB2 and inhibiting ly
|
| Subcellular Location |
Cytoplasm, perinuclear region. Cytoplasm, cytoskeleton, microtubule organizing center, centrosome. Note=Associates with centrosomes predominantly in S and G2 phases but less in G1 phase.
|
| Tissue Specificity |
Widely expressed. {ECO:0000269|PubMed:11739384}.
|
![Western Blot: USP33 Overexpression Lysate (Adult Normal) [NBP2-07230] Left-Empty vector transfected control cell lysate (HEK293 cell lysate); Right -Over-expression Lysate for USP33.](http://www.bioprodhub.com/system/product_images/cel_products/5/sub_2/8459_USP33%2520Overexpression%2520Lysate%2520(Adult%2520Normal)-Western%2520Blot-NBP2-07230-img0001.jpg)