ABCB5

Gene Symbol	ABCB5
Entrez Gene	340273
Alt Symbol	ABCB5alpha, ABCB5beta, EST422562
Species	Human
Gene Type	protein-coding
Description	ATP-binding cassette, sub-family B (MDR/TAP), member 5
Other Description	ABCB5 P-gp|ATP-binding cassette protein|ATP-binding cassette sub-family B member 5|P-glycoprotein ABCB5
Swissprots	Q6KG50 Q5I5Q8 Q5I5Q7 Q6XFQ5 Q2M3G0 B7WPL1 A7BKA4 B5MD19 F8QQP9 F8QQP8 Q8IXA1 Q2M3I5 A4D131 J3KQ04
Accessions	EAL24273 EAL24274 EAW93726 EAW93727 Q2M3G0 AB353947 BAF75364 AF319622 AAN76500 AF399931 AAQ03033 AI334015 AK127141 AL040763 AY090613 AAM09027 AY230001 AAP55848 AY234788 AAO73470 AY785909 AAX11382 AY851364 AAW31629 AY851365 AAW31630 BC044248 BC104894 AAI04895 BC104920 AAI04921 BC110370 BM471690 BX452500 BX537763 GU437216 ADV32636 GU437217 ADV32637 H99394 XM_006715722 XP_006715785 XM_011515367 XP_011513669 XM_011515368 XP_011513670 NM_001163941 NP_001157413 NM_001163942 NP_001157414 NM_001163993 NP_001157465 NM_178559 NP_848654
Function	Drug efflux transporter present in a number of stem cells that acts as a regulator of cellular differentiation. Able to mediate efflux from cells of the rhodamine dye and of the therapeutic drug doxorubicin. Specifically present in limbal stem cells, where it plays a key role in corneal development and repair. {ECO:0000269|PubMed:12960149, ECO:0000269|PubMed:15205344, ECO:0000269|PubMed:15899824, ECO:0000269|PubMed:22306008}.
Subcellular Location	Cell membrane {ECO:0000269|PubMed:12960149}; Multi-pass membrane protein {ECO:0000255|PROSITE-ProRule:PRU00441, ECO:0000269|PubMed:12960149}.
Tissue Specificity	Expressed by CD133-expressing progenitor cells among epidermal melanocytes (at protein level). Widely expressed with specific expression in pigment cells. Highly expressed in several malignant tissues: highly expressed in clinical melanomas, with low expression in normal skin. In melanoma, marks malignant melanoma-initiating cells (MMIC), in which clinical virulence resides as a consequence of unlimited self-renewal capacity, resulting in inexorable tumor progression and metastasis. Also highly expressed in a number of leukemia cells. Expressed in basal limbal epithelium. {ECO:0000269|PubMed:12960149, ECO:0000269|PubMed:15760339, ECO:0000269|PubMed:22044138, ECO:0000269|PubMed:22675422, ECO:0000269|PubMed:22784549, ECO:0000269|PubMed:23770371, ECO:0000269|PubMed:24934811, ECO:0000269|PubMed:25030174}.
Top Pathways	ABC transporters

• Antibodies
• Assays/Kits
• Proteins/Peptides
• siRNAs/Functional Genomics
• cDNA Clones
• Cell/Tissue/Blood Products

Human ABCB5 (NP_001157413) VersaClone cDNA - RDC1226 from R&D Systems Prices $799.00 Sizes 10 µg Species Human

Human ABCB5 (NP_848654) VersaClone cDNA - RDC0843 from R&D Systems Prices $499.00 Sizes 10 µg Species Human

ABCB5 - MBS1269141 from MyBioSource Prices $175.00 Sizes 10ug plasmid + 200ul glycerol stock Species Human Accession BC104894

Human ABCB5 cDNA clone(NM_001163941.1) - CDFH000042 from Creative Biomart Species Human Accession NM_001163941.1

Human ABCB5 cDNA clone(NM_001163942.1) - CDFH000043 from Creative Biomart Species Human Accession NM_001163942.1

Human ABCB5 cDNA clone(NM_001163993.1) - CDFH000044 from Creative Biomart Species Human Accession NM_001163993.1

Human ABCB5 ORF Clone(NM_001163941.1) - CDCL152721 from Creative Biomart Species Human Accession NM_001163941.1

Human ABCB5 ORF Clone(NM_001163941.1) - CDCR354457 from Creative Biomart Species Human Accession NM_001163941.1

Human ABCB5 ORF Clone(NM_001163941.1) - CDCR354458 from Creative Biomart Species Human Accession NM_001163941.1

Human ABCB5 ORF Clone(NM_001163942.1) - CDCR354459 from Creative Biomart Species Human Accession NM_001163942.1

Human ABCB5 ORF Clone(NM_001163942.1) - CDCR354461 from Creative Biomart Species Human Accession NM_001163942.1

Human ABCB5 ORF Clone(NM_001163993.1) - CDCR354469 from Creative Biomart Species Human Accession NM_001163993.1

Human ABCB5 ORF Clone(NM_001163993.1) - CDCR355458 from Creative Biomart Species Human Accession NM_001163993.1

Human ABCB5 Gene ORF cDNA clone in cloning vector - HG15702-G from Sino Biological Species Human

Human ABCB5 Gene ORF cDNA clone expression plasmid, N-HA tag - HG15702-NY from Sino Biological Species Human

Human ABCB5 Gene ORF cDNA clone expression plasmid, N-Flag tag - HG15702-NF from Sino Biological Species Human

Human ABCB5 Gene ORF cDNA clone expression plasmid, C-OFPSpark tag - HG15702-ACR from Sino Biological Species Human

Human ABCB5 Gene ORF cDNA clone expression plasmid, C-His tag - HG15702-CH from Sino Biological Species Human

Human ABCB5 Gene ORF cDNA clone expression plasmid, N-His tag - HG15702-NH from Sino Biological Species Human

Human ABCB5 Gene ORF cDNA clone expression plasmid, C-HA tag - HG15702-CY from Sino Biological Species Human

Human ABCB5 Gene ORF cDNA clone expression plasmid, C-Flag tag - HG15702-CF from Sino Biological Species Human

Human ABCB5 Gene ORF cDNA clone expression plasmid, C-Myc tag - HG15702-CM from Sino Biological Species Human

Human ABCB5 Gene ORF cDNA clone expression plasmid, N-Myc tag - HG15702-NM from Sino Biological Species Human

Human ABCB5 Gene ORF cDNA clone expression plasmid, C-GFPSpark tag - HG15702-ACG from Sino Biological Species Human

Human ABCB5 Gene ORF cDNA clone expression plasmid - HG15702-UT from Sino Biological Species Human

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