ABCB5

Gene Symbol ABCB5
Entrez Gene 340273
Alt Symbol ABCB5alpha, ABCB5beta, EST422562
Species Human
Gene Type protein-coding
Description ATP-binding cassette, sub-family B (MDR/TAP), member 5
Other Description ABCB5 P-gp|ATP-binding cassette protein|ATP-binding cassette sub-family B member 5|P-glycoprotein ABCB5
Swissprots Q6KG50 Q5I5Q8 Q5I5Q7 Q6XFQ5 Q2M3G0 B7WPL1 A7BKA4 B5MD19 F8QQP9 F8QQP8 Q8IXA1 Q2M3I5 A4D131 J3KQ04
Accessions EAL24273 EAL24274 EAW93726 EAW93727 Q2M3G0 AB353947 BAF75364 AF319622 AAN76500 AF399931 AAQ03033 AI334015 AK127141 AL040763 AY090613 AAM09027 AY230001 AAP55848 AY234788 AAO73470 AY785909 AAX11382 AY851364 AAW31629 AY851365 AAW31630 BC044248 BC104894 AAI04895 BC104920 AAI04921 BC110370 BM471690 BX452500 BX537763 GU437216 ADV32636 GU437217 ADV32637 H99394 XM_006715722 XP_006715785 XM_011515367 XP_011513669 XM_011515368 XP_011513670 NM_001163941 NP_001157413 NM_001163942 NP_001157414 NM_001163993 NP_001157465 NM_178559 NP_848654
Function Drug efflux transporter present in a number of stem cells that acts as a regulator of cellular differentiation. Able to mediate efflux from cells of the rhodamine dye and of the therapeutic drug doxorubicin. Specifically present in limbal stem cells, where it plays a key role in corneal development and repair. {ECO:0000269|PubMed:12960149, ECO:0000269|PubMed:15205344, ECO:0000269|PubMed:15899824, ECO:0000269|PubMed:22306008}.
Subcellular Location Cell membrane {ECO:0000269|PubMed:12960149}; Multi-pass membrane protein {ECO:0000255|PROSITE-ProRule:PRU00441, ECO:0000269|PubMed:12960149}.
Tissue Specificity Expressed by CD133-expressing progenitor cells among epidermal melanocytes (at protein level). Widely expressed with specific expression in pigment cells. Highly expressed in several malignant tissues: highly expressed in clinical melanomas, with low expression in normal skin. In melanoma, marks malignant melanoma-initiating cells (MMIC), in which clinical virulence resides as a consequence of unlimited self-renewal capacity, resulting in inexorable tumor progression and metastasis. Also highly expressed in a number of leukemia cells. Expressed in basal limbal epithelium. {ECO:0000269|PubMed:12960149, ECO:0000269|PubMed:15760339, ECO:0000269|PubMed:22044138, ECO:0000269|PubMed:22675422, ECO:0000269|PubMed:22784549, ECO:0000269|PubMed:23770371, ECO:0000269|PubMed:24934811, ECO:0000269|PubMed:25030174}.
Top Pathways ABC transporters

ABCB5 CRISPR/Cas9 KO Plasmid (h) - sc-404392 from Santa Cruz Biotechnology

Category CRISPR
Prices $345.00
Sizes 20 µg
Species Reactivities Human

ABCB5 HDR Plasmid (h) - sc-404392-HDR from Santa Cruz Biotechnology

Prices $345.00
Sizes 20 µg
Species Reactivities Human

ABCB5 Double Nickase Plasmid (h) - sc-404392-NIC from Santa Cruz Biotechnology

Prices $345.00
Sizes 20 µg
Species Reactivities Human

ABCB5 Double Nickase Plasmid (h2) - sc-404392-NIC-2 from Santa Cruz Biotechnology

Prices $345.00
Sizes 20 µg
Species Reactivities Human

ABCB5 CRISPR Activation Plasmid (h) - sc-404392-ACT from Santa Cruz Biotechnology

Category CRISPR
Prices $345.00
Sizes 20 µg
Species Reactivities Human

ABCB5 CRISPR Activation Plasmid (h2) - sc-404392-ACT-2 from Santa Cruz Biotechnology

Category CRISPR
Prices $345.00
Sizes 20 µg
Species Reactivities Human

ABCB5 Lentiviral Activation Particles (h) - sc-404392-LAC from Santa Cruz Biotechnology

Prices $345.00
Sizes 20 µg
Species Reactivities Human

ABCB5 Lentiviral Activation Particles (h2) - sc-404392-LAC-2 from Santa Cruz Biotechnology

Prices $345.00
Sizes 20 µg
Species Reactivities Human

ABCB5 siRNA (h) - sc-89856 from Santa Cruz Biotechnology

Category siRNA
Prices $258.00
Sizes 10 µm
Species Reactivities Human

ABCB5 shRNA Plasmid (h) - sc-89856-SH from Santa Cruz Biotechnology

Category siRNA
Prices $258.00
Sizes 10 µm
Species Reactivities Human

ABCB5 shRNA (h) Lentiviral Particles - sc-89856-V from Santa Cruz Biotechnology

Category siRNA
Prices $258.00
Sizes 10 µm
Species Reactivities Human

ABCB5 RNAi - H00340273-R02 from Novus Biologicals

Category siRNA
Prices $399.00
Sizes 20 nmol
Species Reactivities Human

CompoZr® Knockout ZFN Kit - CKOZFN2628 from Sigma-Aldrich

Category ZFN Kit
Prices $4,999.00
Sizes 1 kt

CompoZr® Knockout ZFN Kit, ZFN plasmid only - CKOZFND2628 from Sigma-Aldrich

Category ZFN Kit
Prices $3,999.00
Sizes 1 kt

ABCB5 siRNA (Human) - CRJ7336 from Cohesion Biosciences

Category siRNA
Prices $340.00, $510.00
Sizes 15 nmol, 30 nmol
Species Reactivities Human

ABCB5 - MBS8230368 from MyBioSource

Prices $365.00, $515.00
Sizes 15 nmol, 30 nmol
Species Reactivities Human

ABCB5 CRISPR/Cas9 KO Plasmid (h2) - sc-404392-KO-2 from Santa Cruz Biotechnology

Category CRISPR
Prices $345.00
Sizes 20 µg
Species Reactivities Human

ABCB5 HDR Plasmid (h2) - sc-404392-HDR-2 from Santa Cruz Biotechnology

Prices $345.00
Sizes 20 µg
Species Reactivities Human

shRNA set against Human ABCB5 (NM_178559.5) - SHH229010 from Creative biogene

Category siRNA
Species Reactivities Human

Human ABCB5 siRNA - orb277837 from Biorbyt

Category siRNA
Prices $485.00, $629.00
Sizes 15 nmol, 30 nmol
Species Reactivities Human

ABCB5 shRNA Plasmid (Human) - CHJ7336 from Cohesion Biosciences

Category siRNA
Prices $500.00, $750.00
Sizes 150 µg, 300 µg
Species Reactivities Human

ABCB5 miRNA 3'UTR clone - MiUTR3H-12097 from Creative biogene

Species Reactivities Human

ABCB5 miRNA 3'UTR clone - MiUTR3H-12098 from Creative biogene

Species Reactivities Human
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