Gene Symbol | TXN2 |
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Entrez Gene | 25828 |
Alt Symbol | MT-TRX, MTRX, TRX2 |
Species | Human |
Gene Type | protein-coding |
Description | thioredoxin 2 |
Other Description | mitochondrial thioredoxin|thioredoxin, mitochondrial|thioredoxin-2 |
Swissprots | Q5JZA0 Q9UH29 Q6FH60 Q99757 |
Accessions | EAW60103 EAW60104 Q99757 AF276920 AAF86467 AF480262 AAN05576 AK123361 AK130187 AK301837 BAG63281 BC013726 AAH13726 BC050610 AAH50610 CR456601 CAG30487 CR541896 CAG46694 CR541917 CAG46715 CU013201 CAK54632 CU013489 CAK54931 DQ891579 ABM82505 DQ894772 ABM85698 DQ895044 ABM85970 U78678 AAB41631 XM_005261508 XP_005261565 XM_006724226 XP_006724289 XM_011530111 XP_011528413 NM_012473 NP_036605 |
Function | Has an anti-apoptotic function and plays an important role in the regulation of mitochondrial membrane potential. Could be involved in the resistance to anti-tumor agents. Possesses a dithiol-reducing activity. {ECO:0000269|PubMed:12032145, ECO:0000269|PubMed:12080052}. |
Subcellular Location | Mitochondrion {ECO:0000269|PubMed:12032145, ECO:0000269|PubMed:12080052}. |
Tissue Specificity | Widely expressed in adult (at protein level) and fetal tissues. {ECO:0000269|PubMed:12032145, ECO:0000269|PubMed:12080052}. |
Trx-2 CRISPR/Cas9 KO Plasmid (h) - sc-402209 from Santa Cruz Biotechnology
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Trx-2 HDR Plasmid (h) - sc-402209-HDR from Santa Cruz Biotechnology
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Trx-2 Double Nickase Plasmid (h) - sc-402209-NIC from Santa Cruz Biotechnology
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Trx-2 Double Nickase Plasmid (h2) - sc-402209-NIC-2 from Santa Cruz Biotechnology
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Trx-2 CRISPR Activation Plasmid (h) - sc-402209-ACT from Santa Cruz Biotechnology
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Trx-2 CRISPR Activation Plasmid (h2) - sc-402209-ACT-2 from Santa Cruz Biotechnology
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Trx-2 Lentiviral Activation Particles (h) - sc-402209-LAC from Santa Cruz Biotechnology
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Trx-2 Lentiviral Activation Particles (h2) - sc-402209-LAC-2 from Santa Cruz Biotechnology
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Trx-2 siRNA (h) - sc-44173 from Santa Cruz Biotechnology
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Trx-2 shRNA Plasmid (h) - sc-44173-SH from Santa Cruz Biotechnology
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Trx-2 shRNA (h) Lentiviral Particles - sc-44173-V from Santa Cruz Biotechnology
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MISSION® esiRNA - EHU011501 from Sigma-Aldrich
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CompoZr® Knockout ZFN Kit - CKOZFN22301 from Sigma-Aldrich
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CompoZr® Knockout ZFN Kit, ZFN plasmid only - CKOZFND22301 from Sigma-Aldrich
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MISSION® 3′UTR Lenti GoClone™ - HUTR06892 from Sigma-Aldrich
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TXN2 siRNA (Human) - CRH8526 from Cohesion Biosciences
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Thioredoxin-2 RNAi - H00025828-R01 from Novus Biologicals
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TXN2 - MBS8237682 from MyBioSource
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shRNA set against Human TXN2 (NM_012473.3) - SHH438176 from Creative biogene
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shRNA set against Human TXN2(NM_012473.3) - SHL107828 from Creative biogene
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TXN2 shRNA Plasmid (Human) - CHH8526 from Cohesion Biosciences
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TXN2 miRNA 3'UTR clone - MiUTR1H-10893 from Creative biogene
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