Gene Symbol | HS3ST6 |
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Entrez Gene | 64711 |
Alt Symbol | 3-OST-6, HS3ST5, h3-OST-6 |
Species | Human |
Gene Type | protein-coding |
Description | heparan sulfate (glucosamine) 3-O-sulfotransferase 6 |
Other Description | heparan sulfate (glucosamine) 3-O-sulfotransferase 5|heparan sulfate D-glucosaminyl 3-O-sulfotransferase 6|heparan sulfate glucosamine 3-O-sulfotransferase 6|heparan sulphate D-glucosaminyl 3-O-sulfotransferase-3B like |
Swissprots | Q96QI5 Q96RX7 |
Accessions | AAK61299 EAW85602 EAW85603 Q96QI5 BC156438 AAI56439 BC172540 AAI72540 CK300523 DY654407 XM_011522608 XP_011520910 XM_011522609 XP_011520911 XM_011546749 XP_011545051 XM_011546750 XP_011545052 NM_001009606 NP_001009606 |
Function | Sulfotransferase that utilizes 3'-phospho-5'-adenylyl sulfate (PAPS) to catalyze the transfer of a sulfo group to heparan sulfate. The substrate-specific O-sulfation generates an enzyme-modified heparan sulfate which acts as a binding receptor to Herpes Simplex Virus-1 (HSV-1) and permits its entry. Unlike 3- OST-1, does not convert non-anticoagulant heparan sulfate to anticoagulant heparan sulfate. {ECO:0000269|PubMed:15303968}. |
Subcellular Location | Golgi apparatus membrane {ECO:0000305}; Single-pass type II membrane protein {ECO:0000305}. |
HS3ST6 CRISPR/Cas9 KO Plasmid (h) - sc-408948 from Santa Cruz Biotechnology
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HS3ST6 HDR Plasmid (h) - sc-408948-HDR from Santa Cruz Biotechnology
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HS3ST6 Double Nickase Plasmid (h) - sc-408948-NIC from Santa Cruz Biotechnology
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HS3ST6 Double Nickase Plasmid (h2) - sc-408948-NIC-2 from Santa Cruz Biotechnology
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HS3ST6 CRISPR Activation Plasmid (h) - sc-408948-ACT from Santa Cruz Biotechnology
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HS3ST6 CRISPR Activation Plasmid (h2) - sc-408948-ACT-2 from Santa Cruz Biotechnology
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HS3ST6 Lentiviral Activation Particles (h) - sc-408948-LAC from Santa Cruz Biotechnology
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HS3ST6 Lentiviral Activation Particles (h2) - sc-408948-LAC-2 from Santa Cruz Biotechnology
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HS3ST6 siRNA (h) - sc-93497 from Santa Cruz Biotechnology
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HS3ST6 shRNA Plasmid (h) - sc-93497-SH from Santa Cruz Biotechnology
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HS3ST6 shRNA (h) Lentiviral Particles - sc-93497-V from Santa Cruz Biotechnology
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CompoZr® Knockout ZFN Kit - CKOZFN10312 from Sigma-Aldrich
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CompoZr® Knockout ZFN Kit, ZFN plasmid only - CKOZFND10312 from Sigma-Aldrich
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shRNA set against Human HS3ST6 (NM_001009606.2) - SHH315021 from Creative biogene
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shRNA set against Human HS3ST6(NM_001009606.2) - SHH131843 from Creative biogene
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HS3ST6 miRNA 3'UTR clone - MiUTR1H-04706 from Creative biogene
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