| Gene Symbol |
LPIN1
|
| Entrez Gene |
23175
|
| Alt Symbol |
PAP1
|
| Species |
Human
|
| Gene Type |
protein-coding
|
| Description |
lipin 1
|
| Other Description |
phosphatidate phosphatase LPIN1
|
| Swissprots |
E7ESE7 D6W506 B5MC18 A8MU38 Q14693 B4DGZ6 B4DET9 B4DGS4 F5GY24 Q53T25 B7Z858
|
| Accessions |
AAY14695 CBX47446 EAX00918 EAX00919 EAX00920 Q14693 AF147446 AI379040 AK127039 AK290235 BAF82924 AK293787 BAG57200 AK294742 BAG57885 AK294853 BAG57957 AK302922 BAH13844 AK310450 AL357194 BC018071 BC030537 AAH30537 BI459149 BP192775 CR749806 CAH18666 D80010 BAA11505 DB086946 DB153243 DC334711 DQ894676 ABM85602 XM_006711869 XP_006711932 XM_006711870 XP_006711933 XM_006711871 XP_006711934 XM_006711872 XP_006711935 XM_006711874 XP_006711937 XM_011510333 XP_011508635 XM_011510334 XP_011508636 XM_011510335 XP_011508637 XM_011510336 XP_011508638 XM_011510337 XP_011508639 XM_011510338 XP_011508640 NM_001261427 NP_001248356 NM_001261428 NP_001248357 NM_001261429 NP_001248358 NM_145693 NP_663731
|
| Function |
Plays important roles in controlling the metabolism of fatty acids at differents levels. Acts as a magnesium-dependent phosphatidate phosphatase enzyme which catalyzes the conversion of phosphatidic acid to diacylglycerol during triglyceride, phosphatidylcholine and phosphatidylethanolamine biosynthesis in the reticulum endoplasmic membrane. Acts also as a nuclear transcriptional coactivator for PPARGC1A/PPARA to modulate lipid metabolism gene expression (By similarity). Is involved in adipocyte differentiation. May also be involved in mitochondrial fission by converting phosphatidic acid to diacylglycerol (By similarity). {ECO:0000250}.
|
| Subcellular Location |
Nucleus membrane {ECO:0000250}. Cytoplasm, cytosol {ECO:0000250}. Endoplasmic reticulum membrane {ECO:0000250}.
|
| Tissue Specificity |
Specifically expressed in skeletal muscle. Also abundant in adipose tissue. Lower levels in some portions of the digestive tract. {ECO:0000269|PubMed:17158099, ECO:0000269|PubMed:22134922}.
|
| Top Pathways |
Glycerolipid metabolism, Glycerophospholipid metabolism
|