LPIN1

Gene Symbol LPIN1
Entrez Gene 23175
Alt Symbol PAP1
Species Human
Gene Type protein-coding
Description lipin 1
Other Description phosphatidate phosphatase LPIN1
Swissprots E7ESE7 D6W506 B5MC18 A8MU38 Q14693 B4DGZ6 B4DET9 B4DGS4 F5GY24 Q53T25 B7Z858
Accessions AAY14695 CBX47446 EAX00918 EAX00919 EAX00920 Q14693 AF147446 AI379040 AK127039 AK290235 BAF82924 AK293787 BAG57200 AK294742 BAG57885 AK294853 BAG57957 AK302922 BAH13844 AK310450 AL357194 BC018071 BC030537 AAH30537 BI459149 BP192775 CR749806 CAH18666 D80010 BAA11505 DB086946 DB153243 DC334711 DQ894676 ABM85602 XM_006711869 XP_006711932 XM_006711870 XP_006711933 XM_006711871 XP_006711934 XM_006711872 XP_006711935 XM_006711874 XP_006711937 XM_011510333 XP_011508635 XM_011510334 XP_011508636 XM_011510335 XP_011508637 XM_011510336 XP_011508638 XM_011510337 XP_011508639 XM_011510338 XP_011508640 NM_001261427 NP_001248356 NM_001261428 NP_001248357 NM_001261429 NP_001248358 NM_145693 NP_663731
Function Plays important roles in controlling the metabolism of fatty acids at differents levels. Acts as a magnesium-dependent phosphatidate phosphatase enzyme which catalyzes the conversion of phosphatidic acid to diacylglycerol during triglyceride, phosphatidylcholine and phosphatidylethanolamine biosynthesis in the reticulum endoplasmic membrane. Acts also as a nuclear transcriptional coactivator for PPARGC1A/PPARA to modulate lipid metabolism gene expression (By similarity). Is involved in adipocyte differentiation. May also be involved in mitochondrial fission by converting phosphatidic acid to diacylglycerol (By similarity). {ECO:0000250}.
Subcellular Location Nucleus membrane {ECO:0000250}. Cytoplasm, cytosol {ECO:0000250}. Endoplasmic reticulum membrane {ECO:0000250}.
Tissue Specificity Specifically expressed in skeletal muscle. Also abundant in adipose tissue. Lower levels in some portions of the digestive tract. {ECO:0000269|PubMed:17158099, ECO:0000269|PubMed:22134922}.
Top Pathways Glycerolipid metabolism, Glycerophospholipid metabolism

Lipin 1 Antibody - 5195 from Cell Signaling Technology

Prices $99.00, $246.00
Sizes 20 µl (2 western blots), 100 µl (10 western blots)
Host Rabbit
Clonality Polyclonal
Western blot analysis of extracts from human white pre-adipocytes and human white adipocytes using Lipin 1 Antibody (upper) and β-Actin Antibody #4967 (lower).

Lipin-1 (B-12) - sc-376874 from Santa Cruz Biotechnology

Prices $279.00
Sizes 200 µg/ml
Host Mouse
Clonality Monoclonal
Lipin-1 (B-12): sc-376874. Western blot analysis of Lipin-1 expression in Jurkat whole cell lysate.

Lipin-1 (H-19) - sc-50050 from Santa Cruz Biotechnology

Prices $279.00
Sizes 200 µg/ml
Host Goat
Clonality Polyclonal

Lipin-1 (H-120) - sc-98450 from Santa Cruz Biotechnology

Prices $279.00
Sizes 200 µg/ml
Host Rabbit
Clonality Polyclonal
Lipin-1 (H-120): sc-98450. Immunoperoxidase staining of formalin fixed, paraffin-embedded human kidney tissue showing cytoplasmic staining of cells in tubules.

Lipin-1 (C-15) - sc-50049 from Santa Cruz Biotechnology

Prices $279.00
Sizes 200 µg/ml
Host Goat
Clonality Polyclonal
Lipin-1 (C-15): sc-50049 Immunoperoxidase staining of formalin fixed, paraffin-embedded human testis tissue showing nuclear and cytoplasmic staining of cells in seminiferous ducts and Leydig cells.

Lipin-1 (S-15) - sc-50052 from Santa Cruz Biotechnology

Prices $279.00
Sizes 200 µg/ml
Host Goat
Clonality Polyclonal

Anti-Lipin 1 antibody - ab181389 from Abcam

Prices $384.00
Sizes 100 µg
Host Rabbit
Clonality Polyclonal
Anti-Lipin 1 antibody (ab181389) at 1 µg/ml + K562 whole cell lysate at 15 µg

Anti-Lipin 1 antibody - ab70138 from Abcam

Prices $385.00
Sizes 100 µg
Host Rabbit
Clonality Polyclonal
All lanes : Anti-Lipin 1 antibody (ab70138) at 1 µg/mlLane 1 : Liver (Mouse) Tissue LysateLane 2 : Pancreas (Mouse) Tissue LysateLane 3 : Kidney (Mouse) Tissue LysateLysates/proteins at 10 µg per lane.SecondaryGoat polyclonal to Rabbit IgG - H&L - Pre-Adsorbed (HRP) at 1/3000 dilutiondeveloped using the ECL techniquePerformed under reducing conditions.

Anti-Lipin 1 antibody - ab84950 from Abcam

Prices $384.00
Sizes 100 µl
Host Rabbit
Clonality Polyclonal
Immunohistochemistry (Formalin/PFA-fixed paraffin-embedded sections) analysis of human pineal tissue labelling Lipin 1 with ab84950 at 1/100. A Cy3-conjugated donkey anti-rabbit IgG (1/200) was used as the secondary antibody. Positive staining shown in the cytoplasm and membrane of cell bodies and processes of pinealocytes. Magnification: 20X. Exposure time: 0.5 - 2.0 seconds. Left - DAPI. Middle - Lipin 1. Right - Merge.

Anti-Lipin 1 antibody - ab53547 from Abcam

Prices $369.00
Sizes 200 µl
Host Goat
Clonality Polyclonal

Anti-Lipin 1 antibody - ab59564 from Abcam

Host Rabbit
Clonality Polyclonal
Anti-Lipin 1 antibody (ab59564) at 2 µg/ml + 3T3-L1 cell lysate. developed using the ECL technique

Anti-Lipin 1 antibody [EPR3725] - ab92316 from Abcam

Prices $387.00
Sizes 100 µl
Host Rabbit
Clonality Monoclonal
Clone EPR3725
All lanes : Anti-Lipin 1 antibody [EPR3725] (ab92316) at 1/1000 dilutionLane 1 : Jurkat cell lysateLane 2 : HepG2 cell lysateLane 3 : HuT-78 cell lysateLysates/proteins at 10 µg per lane.SecondaryHRP labelled goat anti-rabbit at 1/2000 dilution

Anti-Lipin 1 antibody - C-terminal - ab154080 from Abcam

Prices $376.00
Sizes 100 µl
Host Rabbit
Clonality Polyclonal
Anti-Lipin 1 antibody - C-terminal (ab154080) at 1/1000 dilution + H1299 whole cell lysate at 30 µg

Anti-LPIN1 / Lipin 1 Antibody (aa448-574) - LS-C37204 from LifeSpan Bioscience

Prices $605.00
Sizes 100 µg
Host Goat
Clonality Polyclonal

Anti-LPIN1 / Lipin 1 Antibody (aa111-126) - LS-C37203 from LifeSpan Bioscience

Prices $385.00
Sizes 50 µg
Host Rabbit
Clonality Polyclonal

Anti-LPIN1 / Lipin 1 Antibody (aa461-472) - LS-C55064 from LifeSpan Bioscience

Prices $335.00
Sizes 100 µg
Host Goat
Clonality Polyclonal

Anti-LPIN1 / Lipin 1 Antibody (Internal) - LS-C71705 from LifeSpan Bioscience

Prices $435.00
Sizes 100 µl
Host Rabbit
Clonality Polyclonal

Anti-LPIN1 / Lipin 1 Antibody (Internal, Biotin) - LS-C140921 from LifeSpan Bioscience

Prices $365.00
Sizes 100 µl
Host Rabbit
Clonality Polyclonal

Anti-LPIN1 / Lipin 1 Antibody (Internal, DY488) - LS-C141494 from LifeSpan Bioscience

Prices $365.00
Sizes 100 µl
Host Rabbit
Clonality Polyclonal

Anti-LPIN1 / Lipin 1 Antibody (Internal, DY650) - LS-C140922 from LifeSpan Bioscience

Prices $365.00
Sizes 100 µl
Host Rabbit
Clonality Polyclonal

Anti-LPIN1 / Lipin 1 Antibody (Internal, DY550) - LS-C141496 from LifeSpan Bioscience

Prices $365.00
Sizes 100 µl
Host Rabbit
Clonality Polyclonal

Anti-LPIN1 / Lipin 1 Antibody (Internal, HRP) - LS-C141495 from LifeSpan Bioscience

Prices $365.00
Sizes 100 µl
Host Rabbit
Clonality Polyclonal

Anti-LPIN1 / Lipin 1 Antibody (Internal, Biotin) - LS-C141497 from LifeSpan Bioscience

Prices $365.00
Sizes 100 µl
Host Rabbit
Clonality Polyclonal

Anti-LPIN1 / Lipin 1 Antibody (Internal, DY650) - LS-C141498 from LifeSpan Bioscience

Prices $365.00
Sizes 100 µl
Host Rabbit
Clonality Polyclonal

Anti-LPIN1 / Lipin 1 Antibody (Internal, DY488) - LS-C141499 from LifeSpan Bioscience

Prices $365.00
Sizes 100 µl
Host Rabbit
Clonality Polyclonal
Search more