| Gene Symbol | MYLK |
|---|---|
| Entrez Gene | 4638 |
| Alt Symbol | AAT7, KRP, MLCK, MLCK1, MLCK108, MLCK210, MSTP083, MYLK1, smMLCK |
| Species | Human |
| Gene Type | protein-coding |
| Description | myosin light chain kinase |
| Other Description | kinase-related protein|myosin light chain kinase, smooth muscle|myosin, light polypeptide kinase|smooth muscle myosin light chain kinase|telokin |
| Swissprots | O95799 Q14844 Q17S15 O95798 B4DUE3 Q5MYA0 Q6P2N0 Q15746 O95796 Q9UBG5 O95797 Q16794 Q9UIT9 Q7Z4J0 D3DN97 Q9C0L5 Q3ZCP9 Q9UBY6 Q5MY99 |
| Accessions | AAD51380 AAD51381 EAW79435 EAW79436 EAW79437 EAW79438 EAW79439 EAW79440 EAW79441 EAW79442 EAW79443 EAW79444 EAW79445 EAW79446 Q15746 AB037663 BAB21504 AF069601 AAD15921 AF069602 AAD15922 AF069603 AAD15923 AF069604 AAD15924 AF096773 AAD54017 AF096774 AAD54018 AF096775 AAD54019 AF172084 AAQ13607 AK022278 AK025953 AK127437 AK300610 BAG62305 AK311053 AK314412 BAG37033 AK314443 BAG37052 AL832211 AY339601 AAQ02673 AY424269 AAR29061 AY424270 AAR29062 BC015838 BC017811 AAH17811 BC034911 BC040115 BC062755 BC064420 AAH64420 BC064695 BC100761 AAI00762 BC100762 AAI00763 BC100763 AAI00764 BC107783 AAI07784 BC113456 AAI13457 BC113458 AAI13459 BM723621 BU678390 CA391484 CA391924 CA432076 CR749364 CAH18217 DQ642691 ABG25912 DQ642692 ABG25913 U48959 AAC18423 X85337 CAA59685 X90870 CAA62378 Y09530 CAA70723 XM_011512860 XP_011511162 XM_011512861 XP_011511163 XM_011512862 XP_011511164 NM_053025 NP_444253 NM_053026 NP_444254 NM_053027 NP_444255 NM_053028 NP_444256 NM_053031 NP_444259 NM_053032 NP_444260 NM_005965 NM_053029 NM_053030 |
| Function | Calcium/calmodulin-dependent myosin light chain kinase implicated in smooth muscle contraction via phosphorylation of myosin light chains (MLC). Also regulates actin-myosin interaction through a non-kinase activity. Phosphorylates PTK2B/PYK2 and myosin light-chains. Involved in the inflammatory response (e.g. apoptosis, vascular permeability, leukocyte diapedesis), cell motility and morphology, airway hyperreactivity and other activities relevant to asthma. Required for tonic airway smooth muscle contraction that is necessary for physiological and asthmatic airway resistance. Necessary for gastrointestinal motility. Implicated in the regulation of endothelial as well as vascular permeability, probably via the regulation of cytoskeletal rearrangements. In the nervous system it has been shown to control the growth initiation of astrocytic processes in culture and to participate in transmitter release at synapses formed between cultured sympathetic ganglion cells. Critical participant in |
| Subcellular Location | Cytoplasm. Cell projection, lamellipodium. Cleavage furrow. Cytoplasm, cytoskeleton. Note=Localized to stress fibers during interphase and to the cleavage furrow during mitosis. |
| Tissue Specificity | Smooth muscle and non-muscle isozymes are expressed in a wide variety of adult and fetal tissues and in cultured endothelium with qualitative expression appearing to be neither tissue- nor development-specific. Non-muscle isoform 2 is the dominant splice variant expressed in various tissues. Telokin has been found in a wide variety of adult and fetal tissues. Accumulates in well differentiated enterocytes of the intestinal epithelium in response to tumor necrosis factor (TNF). {ECO:0000269|PubMed:10536370, ECO:0000269|PubMed:16835238, ECO:0000269|PubMed:20053363, ECO:0000269|PubMed:8575746}. |
| Top Pathways | Focal adhesion, Calcium signaling pathway, Vascular smooth muscle contraction, Gastric acid secretion, Oxytocin signaling pathway |
Human MYLK ELISA Kit (Sandwich ELISA) - LS-F5144 from LifeSpan Bioscience
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Rat MYLK ELISA Kit (Sandwich ELISA) - LS-F9188 from LifeSpan Bioscience
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Human MYLK ELISA Kit - abx152432 from Abbexa
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Human Myosin Light Chain Kinase ELISA Kit - abx053484 from Abbexa
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Myosin Light Chain Kinase, MLCK/MYLK, Human, ELISA Kit - E-EL-H1429 from ARP American Research Products
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Myosin Light Chain Kinase (MYLK), Human, ELISA Kit - SEB106Hu from ARP American Research Products
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Myosin light chain kinase, MLCK, Human, ELISA Kit - CSB-E09048h from ARP American Research Products
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Myosin light chain kinase, smooth muscle (MYLK), Human, ELISA Kit - E01M0420 from ARP American Research Products
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Myosin light chain kinase, smooth muscle, MYLK, Human, ELISA Kit - E1106h from ARP American Research Products
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Myosin Light Chain Kinase, MLCK/MYLK, Rabbit, ELISA Kit - E-EL-RB1913 from ARP American Research Products
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Myosin Light Chain Kinase, MLCK/MYLK, Chicken, ELISA Kit - E-EL-Ch0051 from ARP American Research Products
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Myosin Light Chain Kinase, MLCK/MYLK, Porcine, ELISA Kit - E-EL-P0784 from ARP American Research Products
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Myosin Light Chain Kinase, MLCK/MYLK, Guinea Pig, ELISA Kit - E-EL-GP0824 from ARP American Research Products
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Myosin Light Chain Kinase, MLCK/MYLK, Monkey, ELISA Kit - E-EL-MK0554 from ARP American Research Products
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MLCK/MYLK, ELISA Kit - MBS2503193 from MyBioSource
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MLCK/MYLK, ELISA Kit - MBS2505013 from MyBioSource
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MLCK/MYLK, ELISA Kit - MBS2512190 from MyBioSource
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MLCK/MYLK, ELISA Kit - MBS2508352 from MyBioSource
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MLCK/MYLK, ELISA Kit - MBS2506421 from MyBioSource
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MLCK/MYLK, ELISA Kit - MBS2515928 from MyBioSource
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MLCK/MYLK, ELISA Kit - MBS2501883 from MyBioSource
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Myosin Light Chain Kinase, ELISA Kit - MBS063753 from MyBioSource
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Myosin Light Chain Kinase, ELISA Kit - MBS077853 from MyBioSource
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Myosin Light Chain Kinase, ELISA Kit - MBS085046 from MyBioSource
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myosin light chain kinase, ELISA Kit - MBS704311 from MyBioSource
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