| Gene Symbol |
WDR4
|
| Entrez Gene |
10785
|
| Alt Symbol |
TRM82, TRMT82
|
| Species |
Human
|
| Gene Type |
protein-coding
|
| Description |
WD repeat domain 4
|
| Other Description |
TRM82 tRNA methyltransferase 82 homolog|WD repeat-containing protein 4|tRNA (guanine-N(7)-)-methyltransferase non-catalytic subunit WDR4|tRNA (guanine-N(7)-)-methyltransferase subunit WDR4
|
| Swissprots |
Q9HCR3 B4DNQ7 P57081 D3DSK3 Q9BVM5 B2RCA3 A8KA58
|
| Accessions |
BAB13726 CAC38543 EAX09527 EAX09528 EAX09529 P57081 AJ243912 CAB93144 AJ243913 CAB93145 AK056343 BAG51684 AK292923 BAF85612 AK298015 BAG60319 AK315008 BAG37500 BC001074 AAH01074 BC006341 AAH06341 BC018866 BG722541 BQ447230 BU541429 BU558089 CD368164 DA029985 DC303088 DQ892967 ABM83893 DQ896215 ABM87214 XM_011529433 XP_011527735 XR_937429 XR_937430 XR_937431 NM_001260474 NP_001247403 NM_001260475 NP_001247404 NM_001260476 NP_001247405 NM_001260477 NP_001247406 NM_018669 NP_061139 NM_033661 NP_387510 NR_048535
|
| Function |
Required for the formation of N(7)-methylguanine at position 46 (m7G46) in tRNA. In the complex, it is required to stabilize and induce conformational changes of the catalytic subunit. {ECO:0000255|HAMAP-Rule:MF_03056, ECO:0000269|PubMed:12403464}.
|
| Subcellular Location |
Nucleus {ECO:0000255|HAMAP-Rule:MF_03056, ECO:0000269|PubMed:15861136}.
|
![Western Blot: WDR4 Overexpression Lysate (Adult Normal) [NBL1-17803] Left-Empty vector transfected control cell lysate (HEK293 cell lysate); Right -Over-expression Lysate for WDR4.](http://www.bioprodhub.com/system/product_images/cel_products/5/sub_1/8200_WDR4%2520Overexpression%2520Lysate%2520%2528Adult%2520Normal%2529-Western%2520Blot-NBL1-17803-img0002.jpg)