Gene Symbol | WDR4 |
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Entrez Gene | 10785 |
Alt Symbol | TRM82, TRMT82 |
Species | Human |
Gene Type | protein-coding |
Description | WD repeat domain 4 |
Other Description | TRM82 tRNA methyltransferase 82 homolog|WD repeat-containing protein 4|tRNA (guanine-N(7)-)-methyltransferase non-catalytic subunit WDR4|tRNA (guanine-N(7)-)-methyltransferase subunit WDR4 |
Swissprots | Q9HCR3 B4DNQ7 P57081 D3DSK3 Q9BVM5 B2RCA3 A8KA58 |
Accessions | BAB13726 CAC38543 EAX09527 EAX09528 EAX09529 P57081 AJ243912 CAB93144 AJ243913 CAB93145 AK056343 BAG51684 AK292923 BAF85612 AK298015 BAG60319 AK315008 BAG37500 BC001074 AAH01074 BC006341 AAH06341 BC018866 BG722541 BQ447230 BU541429 BU558089 CD368164 DA029985 DC303088 DQ892967 ABM83893 DQ896215 ABM87214 XM_011529433 XP_011527735 XR_937429 XR_937430 XR_937431 NM_001260474 NP_001247403 NM_001260475 NP_001247404 NM_001260476 NP_001247405 NM_001260477 NP_001247406 NM_018669 NP_061139 NM_033661 NP_387510 NR_048535 |
Function | Required for the formation of N(7)-methylguanine at position 46 (m7G46) in tRNA. In the complex, it is required to stabilize and induce conformational changes of the catalytic subunit. {ECO:0000255|HAMAP-Rule:MF_03056, ECO:0000269|PubMed:12403464}. |
Subcellular Location | Nucleus {ECO:0000255|HAMAP-Rule:MF_03056, ECO:0000269|PubMed:15861136}. |
WDR4 CRISPR/Cas9 KO Plasmid (h) - sc-411511 from Santa Cruz Biotechnology
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WDR4 HDR Plasmid (h) - sc-411511-HDR from Santa Cruz Biotechnology
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WDR4 Double Nickase Plasmid (h) - sc-411511-NIC from Santa Cruz Biotechnology
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WDR4 Double Nickase Plasmid (h2) - sc-411511-NIC-2 from Santa Cruz Biotechnology
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WDR4 CRISPR Activation Plasmid (h) - sc-411511-ACT from Santa Cruz Biotechnology
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WDR4 CRISPR Activation Plasmid (h2) - sc-411511-ACT-2 from Santa Cruz Biotechnology
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WDR4 Lentiviral Activation Particles (h) - sc-411511-LAC from Santa Cruz Biotechnology
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WDR4 Lentiviral Activation Particles (h2) - sc-411511-LAC-2 from Santa Cruz Biotechnology
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WDR4 siRNA (h) - sc-91529 from Santa Cruz Biotechnology
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WDR4 shRNA Plasmid (h) - sc-91529-SH from Santa Cruz Biotechnology
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WDR4 shRNA (h) Lentiviral Particles - sc-91529-V from Santa Cruz Biotechnology
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WDR4 RNAi - H00010785-R01 from Novus Biologicals
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MISSION® esiRNA - EHU077351 from Sigma-Aldrich
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CompoZr® Knockout ZFN Kit - CKOZFN22824 from Sigma-Aldrich
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CompoZr® Knockout ZFN Kit, ZFN plasmid only - CKOZFND22824 from Sigma-Aldrich
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MISSION® 3′UTR Lenti GoClone™ - HUTR07190 from Sigma-Aldrich
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WDR4 siRNA (Human) - CRH7349 from Cohesion Biosciences
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WDR4 RNAi - H00010785-R02 from Novus Biologicals
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WDR4 - MBS8226197 from MyBioSource
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shRNA set against Human WDR4 (NM_018669.5) - SHH446144 from Creative biogene
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Human WDR4 siRNA - orb267851 from Biorbyt
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WDR4 shRNA Plasmid (Human) - CHH7349 from Cohesion Biosciences
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WDR4 miRNA 3'UTR clone - MiUTR3H-08050 from Creative biogene
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WDR4 miRNA 3'UTR clone - MiUTR3H-08051 from Creative biogene
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