| Gene Symbol |
Glud1
|
| Entrez Gene |
24399
|
| Alt Symbol |
Ac2-281, Gdh1, Glud, Gludeha, MRG-2
|
| Species |
Rat
|
| Gene Type |
protein-coding
|
| Description |
glutamate dehydrogenase 1
|
| Other Description |
glutamate dehydrogenase 1, mitochondrial|memory-related gene 2 protein
|
| Swissprots |
P10860 Q6LC16 Q66HI8
|
| Accessions |
CAA45717 EDL88881 EDL88882 P10860 AY321350 AAP86282 BC081841 AAH81841 FQ210745 FQ212113 FQ212750 FQ214067 FQ219417 U95148 AAB70012 X14044 CAA32202 X14223 CAA32441 NM_012570 NP_036702
|
| Function |
Mitochondrial glutamate dehydrogenase that converts L- glutamate into alpha-ketoglutarate. Plays a key role in glutamine anaplerosis by producing alpha-ketoglutarate, an important intermediate in the tricarboxylic acid cycle (By similarity). May be involved in learning and memory reactions by increasing the turnover of the excitatory neurotransmitter glutamate. {ECO:0000250, ECO:0000269|PubMed:9275181}.
|
| Subcellular Location |
Mitochondrion matrix.
|
| Tissue Specificity |
Widely expressed throughout the hippocampus. After induction by training, highly expressed in the dentate gyrus, pyrimidal layer and lacunosum molecolare. {ECO:0000269|PubMed:9275181}.
|
| Top Pathways |
Nitrogen metabolism, Proximal tubule bicarbonate reclamation, Arginine and proline metabolism, Alanine, aspartate and glutamate metabolism, D-Glutamine and D-glutamate metabolism
|