| Gene Symbol |
SLC4A7
|
| Entrez Gene |
9497
|
| Alt Symbol |
NBC2, NBC3, NBCN1, SBC2, SLC4A6
|
| Species |
Human
|
| Gene Type |
protein-coding
|
| Description |
solute carrier family 4, sodium bicarbonate cotransporter, member 7
|
| Other Description |
bicarbonate transporter|electroneutral Na/HCO(3) cotransporter|sodium bicarbonate cotransporter 2|sodium bicarbonate cotransporter 2b|sodium bicarbonate cotransporter 3|solute carrier family 4 member 7
|
| Swissprots |
B6DY53 B5M451 Q9HC88 O60350 B5M449 B2CI53 Q9UIB9 Q6AHZ9 A6NIA8 C9JST9 D3K175 B5M453 B6DY52 D3K174 Q9Y6M7 B5M452
|
| Accessions |
EAW64381 EAW64382 EAW64383 EAW64384 Q9Y6M7 AA569234 AB012130 BAA25898 AF047033 AAD38322 AF053755 AAF21720 AF089726 AAG16773 AK309734 AK310865 AL389947 AL833589 BC156213 AAI56214 BC172463 AAI72463 CR627428 CAH10515 DA756057 EU499349 ACB47400 EU934246 ACH61958 EU934247 ACH61959 EU934248 ACH61960 EU934249 ACH61961 EU934250 ACH61962 FJ178574 ACI24740 FJ178575 ACI24741 FJ178576 ACI24742 GU354307 ADC32649 GU354308 ADC32650 GU354309 ADC32651 GU354310 ADC32652 XM_005265598 XP_005265655 XM_005265600 XP_005265657 XM_005265601 XP_005265658 XM_006713421 XP_006713484 XM_011534255 XP_011532557 XM_011534256 XP_011532558 XM_011534257 XP_011532559 XM_011534258 XP_011532560 XM_011534259 XP_011532561 XM_011534260 XP_011532562 XM_011534261 XP_011532563 XM_011534262 XP_011532564 XM_011534263 XP_011532565 XM_011534264 XP_011532566 XM_011534265 XP_011532567 XR_940517 XR_940518 XR_940519 NM_001258379 NP_001245308 NM_001258380 NP_001245309 NM_003615 NP_003606
|
| Function |
Electroneutral sodium- and bicarbonate-dependent cotransporter with a Na(+):HCO3(-) 1:1 stoichiometry. Regulates intracellular pH and may play a role in bicarbonate salvage in secretory epithelia. May also have an associated sodium channel activity. {ECO:0000269|PubMed:10347222, ECO:0000269|PubMed:12403779}.
|
| Subcellular Location |
Basolateral cell membrane; Multi-pass membrane protein. Apical cell membrane {ECO:0000250}; Multi-pass membrane protein {ECO:0000250}. Cell projection, stereocilium {ECO:0000250}. Note=Also described at the apical cell membrane. Localizes to the stereocilia of cochlear outer hair cells and to the lateral membrane of cochlear inner hair cells (By similarity). {ECO:0000250}.
|
| Tissue Specificity |
Highly expressed in testis and spleen. Also expressed in retina, colon, small intestine, ovary, thymus, prostate, muscle, heart and kidney. Isoform 1 is expressed in skeletal muscle and heart muscle. {ECO:0000269|PubMed:9610397}.
|