RELA
| Gene Symbol | RELA |
|---|---|
| Entrez Gene | 5970 |
| Alt Symbol | NFKB3, p65 |
| Species | Human |
| Gene Type | protein-coding |
| Description | v-rel avian reticuloendotheliosis viral oncogene homolog A |
| Other Description | NF-kappa-B p65delta3|nuclear factor NF-kappa-B p65 subunit|nuclear factor of kappa light polypeptide gene enhancer in B-cells 3|transcription factor p65|v-rel reticuloendotheliosis viral oncogene homolog A |
| Swissprots | Q04206 Q6GTV1 Q6SLK1 |
| Accessions | AAR13863 CAA80524 CCO13802 EAW74424 EAW74425 EAW74426 Q04206 AK303262 BAG64344 AK308020 AK308478 BC011603 AAH11603 BC014095 AAH14095 BC033522 AAH33522 BC069248 BC110830 AAI10831 BM916512 BU633061 DA020095 L19067 AAA20946 M62399 AAA36408 U33838 AAA92888 U88316 AAB48487 XM_011545206 XP_011543508 XM_011545207 XP_011543509 NM_001145138 NP_001138610 NM_001243984 NP_001230913 NM_001243985 NP_001230914 NM_021975 NP_068810 |
| Function | NF-kappa-B is a pleiotropic transcription factor present in almost all cell types and is the endpoint of a series of signal transduction events that are initiated by a vast array of stimuli related to many biological processes such as inflammation, immunity, differentiation, cell growth, tumorigenesis and apoptosis. NF-kappa-B is a homo- or heterodimeric complex formed by the Rel-like domain-containing proteins RELA/p65, RELB, NFKB1/p105, NFKB1/p50, REL and NFKB2/p52 and the heterodimeric p65-p50 complex appears to be most abundant one. The dimers bind at kappa-B sites in the DNA of their target genes and the individual dimers have distinct preferences for different kappa-B sites that they can bind with distinguishable affinity and specificity. Different dimer combinations act as transcriptional activators or repressors, respectively. NF-kappa-B is controlled by various mechanisms of post-translational modification and subcellular compartmentalization as well as by interactions with ot |
| Subcellular Location | Nucleus. Cytoplasm. Note=Colocalized with DDX1 in the nucleus upon TNF-alpha induction (By similarity). Nuclear, but also found in the cytoplasm in an inactive form complexed to an inhibitor (I-kappa-B). Colocalizes with GFI1 in the nucleus after LPS stimulation. {ECO:0000250}. |
| Top Pathways | Sphingolipid signaling pathway, Apoptosis, Herpes simplex infection, Prolactin signaling pathway, Legionellosis |
Human NF-kB p65 (acetyl K310) peptide - ab20612 from Abcam
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Human NF-kB p65 (phospho S529) peptide - ab101479 from Abcam
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Human NF-kB p65 (phospho T435) peptide - ab20615 from Abcam
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Human NF-kB p65 (unmodified T435) peptide - ab20616 from Abcam
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Human NF-kB p65 full length protein - ab131741 from Abcam
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Human NF-kB p65 peptide - ab16636 from Abcam
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Human NF-kB p65 peptide - ab20613 from Abcam
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Human NF-kB p65 protein fragment - ab114150 from Abcam
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Human NF-kB p65 protein fragment - ab114151 from Abcam
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Mouse NF-kB p65 (phospho S276) peptide - ab13751 from Abcam
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Mouse NF-kB p65 peptide - ab13752 from Abcam
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NF-kB p65 (phospho S281) peptide - ab202904 from Abcam
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NF-kB p65 (phospho S536) peptide - ab202905 from Abcam
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NF-kB p65 (phospho T254) peptide - ab202903 from Abcam
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NF-kB p65 peptide - ab8005 from Abcam
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NF-kB p65 peptide - ab7551 from Abcam
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NF-kB p65 peptide - ab7553 from Abcam
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NF-kB p65 peptide - ab202370 from Abcam
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NF-kB p65 peptide - ab116684 from Abcam
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RELA / NFKB p65 Antibody Blocking Peptide - LS-E10553 from LifeSpan Bioscience
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RELA / NFKB p65 Antibody Blocking Peptide - LS-E10578 from LifeSpan Bioscience
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RELA / NFKB p65 Antibody Blocking Peptide - LS-E10836 from LifeSpan Bioscience
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RELA / NFKB p65 Antibody Blocking Peptide - LS-E22541 from LifeSpan Bioscience
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RELA / NFKB p65 Blocking Peptide - LS-E7289 from LifeSpan Bioscience
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RELA / NFKB p65 Blocking Peptide - LS-E7290 from LifeSpan Bioscience
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