RELA

Gene Symbol	RELA
Entrez Gene	5970
Alt Symbol	NFKB3, p65
Species	Human
Gene Type	protein-coding
Description	v-rel avian reticuloendotheliosis viral oncogene homolog A
Other Description	NF-kappa-B p65delta3|nuclear factor NF-kappa-B p65 subunit|nuclear factor of kappa light polypeptide gene enhancer in B-cells 3|transcription factor p65|v-rel reticuloendotheliosis viral oncogene homolog A
Swissprots	Q04206 Q6GTV1 Q6SLK1
Accessions	AAR13863 CAA80524 CCO13802 EAW74424 EAW74425 EAW74426 Q04206 AK303262 BAG64344 AK308020 AK308478 BC011603 AAH11603 BC014095 AAH14095 BC033522 AAH33522 BC069248 BC110830 AAI10831 BM916512 BU633061 DA020095 L19067 AAA20946 M62399 AAA36408 U33838 AAA92888 U88316 AAB48487 XM_011545206 XP_011543508 XM_011545207 XP_011543509 NM_001145138 NP_001138610 NM_001243984 NP_001230913 NM_001243985 NP_001230914 NM_021975 NP_068810
Function	NF-kappa-B is a pleiotropic transcription factor present in almost all cell types and is the endpoint of a series of signal transduction events that are initiated by a vast array of stimuli related to many biological processes such as inflammation, immunity, differentiation, cell growth, tumorigenesis and apoptosis. NF-kappa-B is a homo- or heterodimeric complex formed by the Rel-like domain-containing proteins RELA/p65, RELB, NFKB1/p105, NFKB1/p50, REL and NFKB2/p52 and the heterodimeric p65-p50 complex appears to be most abundant one. The dimers bind at kappa-B sites in the DNA of their target genes and the individual dimers have distinct preferences for different kappa-B sites that they can bind with distinguishable affinity and specificity. Different dimer combinations act as transcriptional activators or repressors, respectively. NF-kappa-B is controlled by various mechanisms of post-translational modification and subcellular compartmentalization as well as by interactions with ot
Subcellular Location	Nucleus. Cytoplasm. Note=Colocalized with DDX1 in the nucleus upon TNF-alpha induction (By similarity). Nuclear, but also found in the cytoplasm in an inactive form complexed to an inhibitor (I-kappa-B). Colocalizes with GFI1 in the nucleus after LPS stimulation. {ECO:0000250}.
Top Pathways	Sphingolipid signaling pathway, Apoptosis, Herpes simplex infection, Prolactin signaling pathway, Legionellosis

• Antibodies
• Assays/Kits
• Proteins/Peptides
• siRNAs/Functional Genomics
• cDNA Clones
• Cell/Tissue/Blood Products

PathScan ® Phospho-NF-κB p65 (Ser536) Sandwich ELISA Kit - 7173 from Cell Signaling Technology Category ELISA Kit Prices $489.00 Sizes 1 kit (96 assays)

PathScan ® Phospho-NF-κB p65 (Ser536) Sandwich ELISA Antibody Pair - 7834 from Cell Signaling Technology Category Antibody Pair Prices $459.00 Sizes 1 kit (Reagents for 4 x 96 well plates)

PathScan ® Total NF-κB p65 Sandwich ELISA Kit - 7174 from Cell Signaling Technology Category ELISA Kit Prices $489.00 Sizes 1 kit (96 assays)

PathScan ® Total NF-κB p65 Sandwich ELISA Antibody Pair - 7836 from Cell Signaling Technology Category Antibody Pair Prices $459.00 Sizes 1 kit (Reagents for 4 x 96 well plates)

NF kappaB p65 (pS536) + Total SimpleStep ELISA™ Kit - ab176663 from Abcam Category ELISA Kit Prices $484.00 Sizes 1 x 96 tests

NF kappaB p65 (pS536) SimpleStep ELISA™ Kit - ab176647 from Abcam Category ELISA Kit Prices $484.00 Sizes 1 x 96 tests Sensitivity < 5 µg/ml Range 6 µg/ml - 600 µg/ml

NF kappaB p65 Total SimpleStep ELISA™ Kit - ab176648 from Abcam Category ELISA Kit Prices $484.00 Sizes 1 x 96 tests Sensitivity < 5 µg/ml Range 6 µg/ml - 600 µg/ml

NF-kappaB p65 (pS536) PhosphoTracer ELISA Kit - ab119636 from Abcam Category ELISA Kit Prices $489.00 Sizes 1 x 96 tests Sensitivity 10 µg protein/ml Range 10 µg protein/ml - 1000 µg protein/ml

NF-kappaB p65 Total PhosphoTracer ELISA Kit - ab119637 from Abcam Category ELISA Kit Sensitivity 10 µg protein/ml Range 10 µg protein/ml - 1000 µg protein/ml

NFkappaB p65 pSer536 + Total PhosphoTracer ELISA Kit - ab119664 from Abcam Category ELISA Kit Sensitivity 10 µg protein/ml Range 10 µg protein/ml - 1000 µg protein/ml

NF-kB p50/p65 Transcription Factor Assay Kit - ab133128 from Abcam Category Cellular Assay Prices $494.00 Sizes 96 tests

NFkB p65 Transcription Factor Assay Kit - ab133112 from Abcam Category Cellular Assay Prices $494.00 Sizes 96 tests

Rat RELA / NFKB p65 ELISA Kit (Sandwich ELISA) - LS-F4342 from LifeSpan Bioscience Category ELISA Kit Prices $700.00 Sizes 1 plate Sensitivity 0.058 ng/ml Range 0.156-10 ng/ml

Human RELA / NFKB p65 ELISA Kit (Sandwich ELISA) - LS-F4341 from LifeSpan Bioscience Category ELISA Kit Prices $650.00 Sizes 1 plate Sensitivity 0.156 ng/ml Range 0.156-10 ng/ml

Mouse/Human/Rat Phospho-RELA / NFKB p65 (Ser529) ELISA Kit (DNA-Binding Phosphorylation ELISA) - LS-F894 from LifeSpan Bioscience Category ELISA Kit Prices $750.00 Sizes 1 plate Range 0.156-10 ng/ml

Mouse/Human Phospho-RELA / NFKB p65 (Ser276) ELISA Kit (DNA-Binding Phosphorylation ELISA) - LS-F895 from LifeSpan Bioscience Category ELISA Kit Prices $750.00 Sizes 1 plate Range 0.156-10 ng/ml

Mouse/Human/Rat Phospho-RELA / NFKB p65 (Ser468) ELISA Kit (DNA-Binding Phosphorylation ELISA) - LS-F896 from LifeSpan Bioscience Category ELISA Kit Prices $750.00 Sizes 1 plate Range 0.156-10 ng/ml

Mouse/Human/Rat RELA / NFKB p65 ELISA Kit (DNA-Binding ELISA) - LS-F897 from LifeSpan Bioscience Category ELISA Kit Prices $700.00 Sizes 1 plate Range 0.156-10 ng/ml

Mouse/Human/Rat Phospho-RELA / NFKB p65 (Ser529) ELISA Kit (Cell-Based Phosphorylation ELISA) - LS-F1111 from LifeSpan Bioscience Category ELISA Kit Prices $550.00 Sizes 1 plate Range 0.156-10 ng/ml

Mouse/Human Phospho-RELA / NFKB p65 (Ser311) ELISA Kit (DNA-Binding Phosphorylation ELISA) - LS-F927 from LifeSpan Bioscience Category ELISA Kit Prices $750.00 Sizes 1 plate Range 0.156-10 ng/ml

Mouse/Human Phospho-RELA / NFKB p65 (Ser311) ELISA Kit (Cell-Based Phosphorylation ELISA) - LS-F1573 from LifeSpan Bioscience Category ELISA Kit Prices $550.00 Sizes 1 plate Range 0.156-10 ng/ml

Mouse/Human/Rat Phospho-RELA / NFKB p65 (Ser276) ELISA Kit (Cell-Based Phosphorylation ELISA) - LS-F1578 from LifeSpan Bioscience Category ELISA Kit Prices $550.00 Sizes 1 plate Range 0.156-10 ng/ml

Mouse/Human/Rat Phospho-RELA / NFKB p65 (Ser536) ELISA Kit (Cell-Based Phosphorylation ELISA) - LS-F1580 from LifeSpan Bioscience Category ELISA Kit Prices $550.00 Sizes 1 plate Range 0.156-10 ng/ml

Mouse/Human/Rat Phospho-RELA / NFKB p65 (Ser468) ELISA Kit (Cell-Based Phosphorylation ELISA) - LS-F1579 from LifeSpan Bioscience Category ELISA Kit Prices $550.00 Sizes 1 plate Range 0.156-10 ng/ml

Mouse/Human/Rat Phospho-RELA / NFKB p65 (Thr254) ELISA Kit (Cell-Based Phosphorylation ELISA) - LS-F1581 from LifeSpan Bioscience Category ELISA Kit Prices $550.00 Sizes 1 plate Range 0.156-10 ng/ml

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