NPM1

Gene Symbol NPM1
Entrez Gene 4869
Alt Symbol B23, NPM
Species Human
Gene Type protein-coding
Description nucleophosmin (nucleolar phosphoprotein B23, numatrin)
Other Description nucleolar protein NO38|nucleophosmin|nucleophosmin/nucleoplasmin family, member 1
Swissprots A8K3N7 P06748 Q96EA5 Q8WTW5 B5BU00 Q5EU97 Q5EU98 Q5EU96 Q5EU99 P08693 Q12826 Q9UDJ7 Q96AT6 Q13440 Q5EU95 Q9BYG9 Q5EU94 Q14115 Q96DC4 D3DQL6 Q13441 Q6V962
Accessions AAB94739 ACA50454 EAW61443 EAW61444 EAW61445 EAW61446 EAW61447 EAW61448 EAW61449 P06748 AB042278 BAB40600 AB451236 BAG70050 AB451361 BAG70175 AI687394 AK000472 BAA91188 AK290652 BAF83341 AY347529 AAQ24860 AY740634 AAW67752 AY740635 AAW67753 AY740636 AAW67754 AY740637 AAW67755 AY740638 AAW67756 AY740639 AAW67757 AY740640 AAW67758 BC002398 AAH02398 BC003670 AAH03670 BC008495 AAH08495 BC009623 AAH09623 BC012566 AAH12566 BC014349 AAH14349 BC016716 AAH16716 BC016768 AAH16768 BC016824 AAH16824 BC020467 BC021668 AAH21668 BC021983 AAH21983 BC024716 BC050628 AAH50628 BC107754 AAI07755 BP291033 BT007011 AAP35657 BU661768 D28343 BAA05709 DQ303464 ABC40399 DQ892032 ABM82958 DQ895223 ABM86149 EF429251 ABP97432 J02590 AAA36473 M23613 AAA36380 M26697 AAA36385 M28699 AAA58386 M31004 AAA36474 X16934 CAA34809 XM_005265920 XP_005265977 XM_011534564 XP_011532866 NM_001037738 NP_001032827 NM_002520 NP_002511 NM_199185 NP_954654
Function Involved in diverse cellular processes such as ribosome biogenesis, centrosome duplication, protein chaperoning, histone assembly, cell proliferation, and regulation of tumor suppressors p53/TP53 and ARF. Binds ribosome presumably to drive ribosome nuclear export. Associated with nucleolar ribonucleoprotein structures and bind single-stranded nucleic acids. Acts as a chaperonin for the core histones H3, H2B and H4. Stimulates APEX1 endonuclease activity on apurinic/apyrimidinic (AP) double- stranded DNA but inhibits APEX1 endonuclease activity on AP single-stranded RNA. May exert a control of APEX1 endonuclease activity within nucleoli devoted to repair AP on rDNA and the removal of oxidized rRNA molecules. In concert with BRCA2, regulates centrosome duplication. Regulates centriole duplication: phosphorylation by PLK2 is able to trigger centriole replication. Negatively regulates the activation of EIF2AK2/PKR and suppresses apoptosis through inhibition of EIF2AK2/PKR autophosphorylati
Subcellular Location Nucleus, nucleolus. Nucleus, nucleoplasm. Cytoplasm, cytoskeleton, microtubule organizing center, centrosome. Note=Generally nucleolar, but is translocated to the nucleoplasm in case of serum starvation or treatment with anticancer drugs. Has been found in the cytoplasm in patients with primary acute myelogenous leukemia (AML), but not with secondary AML. Can shuttle between cytoplasm and nucleus. Co- localizes with the methylated form of RPS10 in the granular component (GC) region of the nucleolus. Colocalized with nucleolin and APEX1 in nucleoli. Isoform 1 of NEK2 is required for its localization to the centrosome during mitosis.

SimpleChIP ® Human NPM1 Intron 1 Primers - 4779 from Cell Signaling Technology

Category ChIP Kit
Prices $102.00
Sizes 500 µl (250 PCR reactions)
SimpleChIP ® Human NPM1 Intron 1 Primers were tested on DNA isolated from cross-linked cells using the SimpleChIP ® Enzymatic Chromatin IP Kit (Magnetic Beads) #9003. Real-time PCR was performed in duplicate on a serial dilution of 2% total input DNA (20 ng, 4 ng, 0.8 ng, and 0.16 ng) using a real-time PCR detection system and SYBR ® Green reaction mix. The PCR amplification efficiency (E) and correlation coefficient (R 2 ) were calculated based on the corresponding threshold cycle (C T ) of each dilution sample during 40 cycles of real-time PCR (95°C denaturation for 15 sec, 65°C anneal/extension for 60 sec).

Human NPM1 / NPM / Nucleophosmin ELISA Kit (Sandwich ELISA) - LS-F6787 from LifeSpan Bioscience

Category ELISA Kit
Prices $720.00
Sizes 1 plate
Sensitivity 0.122 ng/ml
Range 0.313-20 ng/ml

Mouse/Human/Rat Phospho-NPM1 / NPM / Nucleophosmin (Thr199) ELISA Kit (Cell-Based Phosphorylation ELISA) - LS-F1265 from LifeSpan Bioscience

Category ELISA Kit
Prices $550.00
Sizes 1 plate
Range 0.313-20 ng/ml

Mouse/Human/Rat Phospho-NPM1 / NPM / Nucleophosmin (Thr234) ELISA Kit (Cell-Based Phosphorylation ELISA) - LS-F1423 from LifeSpan Bioscience

Category ELISA Kit
Prices $550.00
Sizes 1 plate
Range 0.313-20 ng/ml

Mouse/Human/Rat NPM1 / NPM / Nucleophosmin ELISA Kit (Cell-Based ELISA) - LS-F2191 from LifeSpan Bioscience

Category ELISA Kit
Prices $450.00
Sizes 1 plate
Range 0.313-20 ng/ml

Rabbit anti-NPM1 Antibody, Affinity Purified - PLA0254 from Sigma-Aldrich

Prices $323.50
Sizes 100 µl
<B>Immunohistochemistry</B><BR/>Rabbit Anti-NPM1 Antibody, Affinity Purified: <B>Cat. No. PLA0254</B>: Detection of Human and Mouse NPM1 by Immunohistochemistry. Sample: FFPE section of Human breast carcinoma (left) and Mouse renal cell carcinoma (right). Antibody: Affinity purified Rabbit Anti-NPM1 (<B>Cat. No. PLA0254</B>) used at a dilution of 1:1,000 (1 μg/mL). Detection: DAB

Rabbit anti-NPM1 Antibody, Affinity Purified - PLA0253 from Sigma-Aldrich

Prices $323.50
Sizes 100 µl
<B>Immunofluorescence</B>: This antibody is qualified for the Proximity Ligation Assay (PLA). The above image shows representative results for PLA using three color fluorescence, including DAPI stained nuclei (blue), phalloidin stained cytoplasmic F-actin (green), and PLA positive signal (red).

Rabbit anti-NPM1 Antibody, Affinity Purified - PLA0252 from Sigma-Aldrich

Prices $323.50
Sizes 100 µl
<B>Immunofluorescence</B>: This antibody is qualified for the Proximity Ligation Assay (PLA). The above image shows representative results for PLA using three color fluorescence, including DAPI stained nuclei (blue), phalloidin stained cytoplasmic F-actin (green), and PLA positive signal (red).

Human Nucleophosmin ELISA Kit - abx152567 from Abbexa

Category ELISA Kit
Sensitivity 0.128 ng/ml
Range 0.313 ng/ml - 20 ng/ml

Nucleophosmin (NPM), Human, ELISA Kit - SEC664Hu from ARP American Research Products

Category ELISA Kit
Prices $720.00
Sizes 96 t
Sensitivity 0.060ng/mL
Range 0.156-10ng/mL

Nucleophosmin (NPM1), Human, ELISA Kit - CSB-EL015996HU from ARP American Research Products

Category ELISA Kit
Prices $495.00, $695.00, $696.00, $699.00
Sizes 48 t, 96 t, 5 x 96t, 10 x 96t
Sensitivity 5.87 pg/ml
Range 23.5 pg/ml-1500 pg/ml

NPM Colorimetric Cell-Based ELISA Kit - CB5495 from Assay Biotechnology

Category ELISA Kit
Prices $380.00, $760.00, $1,140.00
Sizes 1 kit, 2 kits, 3 kits
Range > 5000 Cells

NPM (Phospho-Thr199) Colorimetric Cell-Based ELISA Kit - CBP1265 from Assay Biotechnology

Category ELISA Kit
Prices $480.00, $960.00, $1,440.00
Sizes 1 kit, 2 kits, 3 kits
Range > 5000 Cells

NPM (Phospho-Thr234) Colorimetric Cell-Based ELISA Kit - CBP1455 from Assay Biotechnology

Category ELISA Kit
Prices $480.00, $960.00, $1,440.00
Sizes 1 kit, 2 kits, 3 kits
Range > 5000 Cells

Nucleophosmin, ELISA Kit - MBS071945 from MyBioSource

Category ELISA Kit
Prices $435.00, $600.00, $2,650.00, $5,205.00
Sizes 48 -strip-wells, 96 -strip-wells, 5x96-strip-wells, 10x96-strip-wells

Nucleophosmin, ELISA Kit - MBS107274 from MyBioSource

Category ELISA Kit
Prices $435.00, $600.00, $2,650.00, $5,205.00
Sizes 48 -strip-wells, 96 -strip-wells, 5x96-strip-wells, 10x96-strip-wells

Nucleophosmin, ELISA Kit - MBS104533 from MyBioSource

Category ELISA Kit
Prices $435.00, $600.00, $2,650.00, $5,205.00
Sizes 48 -strip-wells, 96 -strip-wells, 5x96-strip-wells, 10x96-strip-wells

Nucleophosmin, ELISA Kit - MBS100962 from MyBioSource

Category ELISA Kit
Prices $435.00, $600.00, $2,650.00, $5,205.00
Sizes 48 -strip-wells, 96 -strip-wells, 5x96-strip-wells, 10x96-strip-wells

Nucleophosmin, ELISA Kit - MBS069807 from MyBioSource

Category ELISA Kit
Prices $435.00, $600.00, $2,650.00, $5,205.00
Sizes 48 -strip-wells, 96 -strip-wells, 5x96-strip-wells, 10x96-strip-wells

Nucleophosmin, ELISA Kit - MBS077514 from MyBioSource

Category ELISA Kit
Prices $435.00, $600.00, $2,650.00, $5,205.00
Sizes 48 -strip-wells, 96 -strip-wells, 5x96-strip-wells, 10x96-strip-wells

Nucleophosmin, ELISA Kit - MBS061399 from MyBioSource

Category ELISA Kit
Prices $435.00, $600.00, $2,650.00, $5,205.00
Sizes 48 -strip-wells, 96 -strip-wells, 5x96-strip-wells, 10x96-strip-wells

Nucleophosmin (NPM), ELISA Kit - MBS2024060 from MyBioSource

Category ELISA Kit
Prices $380.00, $565.00, $765.00, $3,130.00, $5,670.00
Sizes 24 -strip-wells, 48 -strip-wells, 96 -strip-wells, 5x96-strip-wells, 10x96-strip-wells
Sensitivity 0.122ng/mL.
Range 0.312-20ng/mL. The standard curve concentrations used for the ELISA's were 20ng/mL, 10ng/mL, 5ng/mL, 2.5ng/mL, 1.25ng/mL, 0.625ng/mL, 0.312ng/mL.

nucleophosmin (nucleolar phosphoprotein B23, numatrin) , ELISA Kit - MBS942879 from MyBioSource

Category ELISA Kit
Prices $250.00, $495.00, $710.00, $2,705.00, $5,145.00
Sizes 24 -strip-wells (Limit 1), 48 -strip-wells, 96 -strip-wells, 5x96-strip-wells, 10x96-strip-wells
Sensitivity <5.8 pg/ml
Range 23.5 pg/ml-1500 pg/ml

Nucleophosmin 3 (NPM3), ELISA Kit - MBS9302457 from MyBioSource

Category ELISA Kit
Prices $435.00, $600.00, $2,650.00, $5,205.00
Sizes 48 -strip-wells, 96 -strip-wells, 5x96-strip-wells, 10x96-strip-wells

ELISA Kit for Nucleophosmin (NPM) - SEC664Hu from Uscn Life Science Inc.

Category ELISA Kit
Sensitivity The minimum detectable dose of this kit is typically less than 0.126ng/mL.
Range 0.313-20ng/mL The standard curve concentrations used for the ELISA’s were 20ng/mL, 10ng/mL, 5ng/mL, 2.5ng/mL, 1.25ng/mL, 0.625ng/mL, 0.313ng/mL
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